alanine transaminase alt Search Results


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  • 99
    Millipore alanine aminotransferase alt
    Less organ damage in mice receiving anti-TGF-β treatment. Levels of (A) BUN, (B) creatinine, (C) <t>AST,</t> and (D) <t>ALT</t> were measured in B. pseudomallei -infected mice ( n = 8/group) that were treated with anti-TGF-β antibody and their controls at 72 h as parameters for organ damage. Expression of AST and BUN were decreased, demonstrating less organ damage. *, P
    Alanine Aminotransferase Alt, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 246 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Hitachi Ltd alanine aminotransferase alt
    PZH has no significant toxicity in EAE rats. (a) The organ coefficient of several organs from the respective group was detected. The levels of <t>ALT</t> (b) and <t>AST</t> (c) for hepatotoxicity as well as CREA (d) and UREA (e) for nephrotoxicity were shown, respectively.
    Alanine Aminotransferase Alt, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 93/100, based on 1354 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Hitachi alanine aminotransferase alt
    Lactobacillus reuteri GMNL-263 improves liver injury and oxidative stress in high-fructose-diet rats. Effects of Lactobacillus reuteri GMNL-263 on expressions of liver injury markers <t>(AST</t> and <t>ALT)</t> ( A ), hepatic enzymatic activities of antioxidant (SOD and GR) ( B ), and pro-inflammatory cytokines (TNF-α and IL-6) ( C ) in high-fructose-diet rats at the end of the experimental period (14 weeks). The data were expressed as mean ± SD (n = 6). SOD, speroxide dismutase; GR, glutathione reductase. AST, aspartate aminotransferase; ALT, alanine aminotransferase; TNF-α, tumor necrosis factorα; IL-6, interleukin 6. #p
    Alanine Aminotransferase Alt, supplied by Hitachi, used in various techniques. Bioz Stars score: 92/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Randox alanine transaminase alt
    Decoction of Hedyotis diffusa (HD) relieves the acute inflammation in hepatitis mouse. a Administration of HD decoction blocked LPS/GALN-induced up-regulation of mRNA levels of CXCL1, TNF-α, IL-1β, MIP-2. b The treatment of HD decoction reduced the expressed levels of TNF-α, IL-1β, IL-6 and MCP-1 in liver of LPS/GALN-injected mice. c Alanine transaminase <t>(ALT)</t> level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of ALT (n = 5). d Aspartate transaminase <t>(AST)</t> level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of AST (n = 5). e Survival of hepatitis mouse was measured after treatment of HD decoction (n = 20, per group) within 20 days. f Effect of HD on LPS/GALN-mediated liver histopathologic changes
    Alanine Transaminase Alt, supplied by Randox, used in various techniques. Bioz Stars score: 92/100, based on 76 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    FUJIFILM alanine transaminase alt
    Effects of MOK pharmacopuncture on the changes of serological parameters in PTU-induced hyperthyroidism rats. MOK pharmacopuncture was subcutaneously administered once daily for 2 weeks, and the levels of (A) glucose, (B) triglyceride, (C) total cholesterol, (D) LDL-cholesterol, (E) <t>AST,</t> and (F) <t>ALT</t> in the sera of rats were measured by automatic blood biochemical analyzer. Data are presented as mean ± standard deviation (n=5 per each group). *P
    Alanine Transaminase Alt, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 92/100, based on 42 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Pointe Scientific alanine aminotransferase alt
    Alterations in plasma levels of <t>AST</t> ( A ), <t>ALT</t> ( B ), and Lactate ( C ) in young (3-month-old) rats at 4 h after normal saline (Sham) or LPS (LPS) injection treated with normal saline (Vehicle) or [D-Arg 1 D-Phe 5 D-Trp 7 , 9 Leu 11 ]-substance P (D-SP). Data are
    Alanine Aminotransferase Alt, supplied by Pointe Scientific, used in various techniques. Bioz Stars score: 93/100, based on 122 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore glutamic pyruvic transaminase
    Alterations in plasma levels of <t>AST</t> ( A ), <t>ALT</t> ( B ), and Lactate ( C ) in young (3-month-old) rats at 4 h after normal saline (Sham) or LPS (LPS) injection treated with normal saline (Vehicle) or [D-Arg 1 D-Phe 5 D-Trp 7 , 9 Leu 11 ]-substance P (D-SP). Data are
    Glutamic Pyruvic Transaminase, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Stanbio alanine aminotransferase alt
    Effects of the FoxO1 inhibitor (AS) and APN on serum <t>AST,</t> <t>ALT,</t> and TG. Serum AST, ALT, and TG were determined by kits (Stanbio Laboratory, TX, USA). Values are expressed as mean ± SD, n = 6/group. ∗ P
    Alanine Aminotransferase Alt, supplied by Stanbio, used in various techniques. Bioz Stars score: 93/100, based on 81 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Teco Diagnostics alanine aminotransferase alt
    In-vivo VASP repression by siRNA dampens hepatic IR injury. A ) <t>LDH-serum</t> levels after hepatic IR in in-vivo targeted repression of VASP with siRNA (siVASP) or non-targeting siRNA (siSCR) B ) Correlating serum levels of AST and C ) <t>ALT</t> of siVASP and siSCR treated WT animals. D ) Representative TTC stained liversections of both groups. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic tissue of siVASP and siSCR treated animals (Data are shown as Mean ± SEM, n = 6, * P
    Alanine Aminotransferase Alt, supplied by Teco Diagnostics, used in various techniques. Bioz Stars score: 92/100, based on 63 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BioSino alanine aminotransferase alt
    SAA treatment blunted myocardial injury in response to pressure-overload. (A) H E staining shows myocyte morphology of right ventricle in the control, model, bosentan, and SAA (0.3, 1, 3 mg/kg)-treated groups. The original magnification of the big images was ×200, and that of small images was ×40. Arrows indicate cellular hypertrophy and disarranged cell bundles. (B–E) SAA and bosentan decreased serum level of <t>AST,</t> <t>ALT,</t> and NT-proBNP in PAH rats. Data are shown as mean±SEM ( n =6). * P
    Alanine Aminotransferase Alt, supplied by BioSino, used in various techniques. Bioz Stars score: 93/100, based on 55 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abcam alanine aminotransferase alt
    In vivo antitumor activity, pharmacokinetics and safety of Db10-Glyco-scTRAIL-FAVS G AA. (A) Colo205-bearing nude mice received 8 i.v. injections of the Db10-Glyco-scTRAIL-FAVS G AA fusion protein (0.1 nmol, 0.3 nmol, or 1.0 nmol) in combination with 8 intraperitoneal (i.p.) injections of bortezomib (Brt; 5µg per injection) every day indicated by dots. Mean ± 95% CI (n = 12 tumors per group). The 1.0 nmol-treated group received an identical regime of Db10-Glyco-scTRAIL-FAVS G AA and bortezomib after regrowth of tumors (volume ∼100 mm 3 ). Therefore, animals were divided into 2 subgroups of fast (I) and slow (II) regrowth. (B, C) Db10-Glyco-scTRAIL-FAVS G AA (168 µg per animal in B / 25 µg per animal in C) was injected i.v. into Colo205-bearing nude mice (B) or CD-1 mice (C). The serum concentrations of the fusion protein were analyzed via ELISA. Mean ± SD (n = 3). (D, E) Activity of alanine aminotransferase <t>(ALT,</t> D) and <t>α-amylase</t> (E) was measured after 4 hours (only for D), 1 day, and 9 d after the first of total 8 injections (every day) of Db10-Glyco-scTRAIL-FAVS G AA (0.1 nmol, 0.3 nmol, or 1.0 nmol; i.v.) and/or bortezomib (Brt, 5 µg; i.p.). Control mice were non-treated. Mean ± SD (n = 3).
    Alanine Aminotransferase Alt, supplied by Abcam, used in various techniques. Bioz Stars score: 92/100, based on 49 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Catachem alanine aminotransferase alt
    Time-dependent changes of serum <t>ALT,</t> <t>ALP</t> and LPCs after LCA exposure
    Alanine Aminotransferase Alt, supplied by Catachem, used in various techniques. Bioz Stars score: 92/100, based on 46 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    BioClin Therapeutics alanine aminotransferase alt
    Time-dependent changes of serum <t>ALT,</t> <t>ALP</t> and LPCs after LCA exposure
    Alanine Aminotransferase Alt, supplied by BioClin Therapeutics, used in various techniques. Bioz Stars score: 92/100, based on 24 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    International Federation of Clinical Chemistry and Laboratory Medicine alanine aminotransferase alt
    Galectin-3 and liver damage marker correlation. Correlations were analyzed between galectin-3 and markers of liver damage in the group of patients with end-stage renal disease and hepatitis C viral infection. Based on r value, correlation can be positive or negative and weak ( r = 0.1–0.3), moderate ( r = 0.3–0.5), and strong ( r > 0.5). (a, b) Moderate negative correlation was obtained between galectin-3 and <t>AST</t> as well as galectin-3 and <t>ALT</t> in ESRD HCV + patients.
    Alanine Aminotransferase Alt, supplied by International Federation of Clinical Chemistry and Laboratory Medicine, used in various techniques. Bioz Stars score: 92/100, based on 36 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Johnson & Johnson alanine aminotransferase alt
    Transplantation of OSKP-iPSC-Heps alleviated steatohepatitis in 18-month-old male MCD diet-fed mouse ( A ) Time course of the changes in serum <t>ALT</t> levels among control diet-fed mice, MCDD-fed mice, and MCDD-fed mice with intrasplenic transplantation of OSKP-iPSC-Heps or SnHeps. ( B ) H E staining showing the fat accumulation and severe hepatocyte vacuolization over the liver from MCDD-fed mice. Effect of intrasplenic transplantation of OSKP-iPSC-Heps or SnHeps on serum ( C ) ALT and ( D ) <t>AST</t> levels, and ( E ) hepatic triglyceride accumulation in MCDD-fed mice. In Panels C, D and E, * P
    Alanine Aminotransferase Alt, supplied by Johnson & Johnson, used in various techniques. Bioz Stars score: 93/100, based on 66 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Siemens AG alanine transaminase alt
    Mean postoperative changes in serum <t>AST</t> (A) and <t>ALT</t> (B). Changes from day of surgery (D0) to Day 6 after surgery (D6) in the septic (S) and nonseptic (NS) groups. There are significant differences between the S and NS groups from as early as the day after surgery. * indicates p
    Alanine Transaminase Alt, supplied by Siemens AG, used in various techniques. Bioz Stars score: 92/100, based on 61 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Asan Pharmaceuticals Co alanine aminotransferase alt
    Liver enzyme ( A ) DB extract attenuated the increase of <t>ALT</t> compared with HFD. ( B ) <t>AST</t> was not increased in HFD compared with ND. Statistical analysis was performed using ANOVA and post hoc analysis using Tukey’s B analysis. Values with different letters are significantly different (P
    Alanine Aminotransferase Alt, supplied by Asan Pharmaceuticals Co, used in various techniques. Bioz Stars score: 93/100, based on 39 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abcam alanine transaminase activity assay kit colorimetric fluorometric
    Liver enzyme ( A ) DB extract attenuated the increase of <t>ALT</t> compared with HFD. ( B ) <t>AST</t> was not increased in HFD compared with ND. Statistical analysis was performed using ANOVA and post hoc analysis using Tukey’s B analysis. Values with different letters are significantly different (P
    Alanine Transaminase Activity Assay Kit Colorimetric Fluorometric, supplied by Abcam, used in various techniques. Bioz Stars score: 97/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Pointe Scientific alt sgpt reagent
    Liver enzyme ( A ) DB extract attenuated the increase of <t>ALT</t> compared with HFD. ( B ) <t>AST</t> was not increased in HFD compared with ND. Statistical analysis was performed using ANOVA and post hoc analysis using Tukey’s B analysis. Values with different letters are significantly different (P
    Alt Sgpt Reagent, supplied by Pointe Scientific, used in various techniques. Bioz Stars score: 89/100, based on 23 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Cayman Chemical alanine aminotransferase alt
    Effects of LFE on hepatic steatosis in ob/ob mice. After 8 weeks of LFE administration, plasma levels of <t>ALT</t> and <t>AST,</t> and TG were determined using commercial kits (A). Liver tissues were frozen and tissue sections were stained with either H E or Oil Red O, and visualized under an optical microscope (B). Hepatic TG contents were measured using commercial kit (C). Plasma levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured using ELISA kits (D). Hepatic mRNA levels of IL-1β and IL-6 were measured (E). *P
    Alanine Aminotransferase Alt, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 93/100, based on 45 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Less organ damage in mice receiving anti-TGF-β treatment. Levels of (A) BUN, (B) creatinine, (C) AST, and (D) ALT were measured in B. pseudomallei -infected mice ( n = 8/group) that were treated with anti-TGF-β antibody and their controls at 72 h as parameters for organ damage. Expression of AST and BUN were decreased, demonstrating less organ damage. *, P

    Journal: Infection and Immunity

    Article Title: Expression and Function of Transforming Growth Factor ? in Melioidosis

    doi: 10.1128/IAI.05534-11

    Figure Lengend Snippet: Less organ damage in mice receiving anti-TGF-β treatment. Levels of (A) BUN, (B) creatinine, (C) AST, and (D) ALT were measured in B. pseudomallei -infected mice ( n = 8/group) that were treated with anti-TGF-β antibody and their controls at 72 h as parameters for organ damage. Expression of AST and BUN were decreased, demonstrating less organ damage. *, P

    Article Snippet: Aspartate transaminase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine were determined with commercially available kits (Sigma) using a Hitachi analyzer (Boehringer Mannheim, Mannheim, Germany).

    Techniques: Mouse Assay, AST Assay, Infection, Expressing

    CHOP modulates liraglutide-mediated suppression of steatohepatitis Photomicrogaphs of (A) Hematoxylin and Eosin, (B) Oil Red O, and (C) Sirius Red stained liver tissue sections of CHOP −/− mice fed a ND or HFCD for 16 weeks. After 12 weeks of feeding, mice received daily injections of saline or liraglutide (Lira) for 4 weeks. Black arrowheads, inflammatory immune cells; blue arrowheads, fat droplets; black arrows, collagen deposition. (D) Body, (E) liver, and (F) visceral fat weight as well as (G) NASH-CRN score, serum (H) ALT and (I) AST levels, and (J) hepatic hydroxyproline levels measured at the end of the 16 week experiments. Changes in liver and visceral fat weights are reported as percentages of body weight. (K) Quantitative analysis of Sirius Red stained liver tissue sections. Quantitative RT-PCR analysis of hepatic (L) αSMA and (M) TNF-α transcript levels measured at the end of the 16 week experiments. Data are presented as mean ± SEM; n = 5-7 mice per group. Hashtags indicate significant differences ( p

    Journal: Laboratory investigation; a journal of technical methods and pathology

    Article Title: C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis

    doi: 10.1038/labinvest.2016.61

    Figure Lengend Snippet: CHOP modulates liraglutide-mediated suppression of steatohepatitis Photomicrogaphs of (A) Hematoxylin and Eosin, (B) Oil Red O, and (C) Sirius Red stained liver tissue sections of CHOP −/− mice fed a ND or HFCD for 16 weeks. After 12 weeks of feeding, mice received daily injections of saline or liraglutide (Lira) for 4 weeks. Black arrowheads, inflammatory immune cells; blue arrowheads, fat droplets; black arrows, collagen deposition. (D) Body, (E) liver, and (F) visceral fat weight as well as (G) NASH-CRN score, serum (H) ALT and (I) AST levels, and (J) hepatic hydroxyproline levels measured at the end of the 16 week experiments. Changes in liver and visceral fat weights are reported as percentages of body weight. (K) Quantitative analysis of Sirius Red stained liver tissue sections. Quantitative RT-PCR analysis of hepatic (L) αSMA and (M) TNF-α transcript levels measured at the end of the 16 week experiments. Data are presented as mean ± SEM; n = 5-7 mice per group. Hashtags indicate significant differences ( p

    Article Snippet: Serological analysis Blood obtained by cardiac puncture was collected for measurements of serum alanine aminotransferase (ALT), and aspartate aminotransferase (AST) concentrations using an AST and ALT Activity Assay Kit (Sigma-Aldrich, St. Louis, MO).

    Techniques: Staining, Mouse Assay, AST Assay, Quantitative RT-PCR

    Liraglutide treatment attenuates steatohepatitis in HFCD-fed WT mice Photomicrographs of (A) Hematoxylin and Eosin, (B) Oil Red O, and (C) Sirius Red stained liver sections of WT mice fed a ND or HFCD for 16 weeks. After 12 weeks of feeding, mice received daily injections of saline or liraglutide (Lira) for 4 weeks. Black arrowheads, inflammatory immune cells; blue arrowheads, fat droplets; black arrows, collagen deposition. (D) Body, (E) liver, and (F) visceral fat weight as well as (G) NASH-CRN score, serum (H) ALT and (I) AST levels, and (J) hepatic hydroxyproline levels measured at the end of the 16 week experiments. Changes in liver and visceral fat weights are reported as percentages of body weight. (K) Quantitative analysis of Sirius Red stained liver tissue sections. Quantitative RT-PCR analysis of hepatic (L) αSMA and (M) TNF-α transcript levels measured at the end of the 16 week experiments. Data are presented as mean ± SEM; n = 5-7 mice per group. Hashtags indicate significant differences ( p

    Journal: Laboratory investigation; a journal of technical methods and pathology

    Article Title: C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis

    doi: 10.1038/labinvest.2016.61

    Figure Lengend Snippet: Liraglutide treatment attenuates steatohepatitis in HFCD-fed WT mice Photomicrographs of (A) Hematoxylin and Eosin, (B) Oil Red O, and (C) Sirius Red stained liver sections of WT mice fed a ND or HFCD for 16 weeks. After 12 weeks of feeding, mice received daily injections of saline or liraglutide (Lira) for 4 weeks. Black arrowheads, inflammatory immune cells; blue arrowheads, fat droplets; black arrows, collagen deposition. (D) Body, (E) liver, and (F) visceral fat weight as well as (G) NASH-CRN score, serum (H) ALT and (I) AST levels, and (J) hepatic hydroxyproline levels measured at the end of the 16 week experiments. Changes in liver and visceral fat weights are reported as percentages of body weight. (K) Quantitative analysis of Sirius Red stained liver tissue sections. Quantitative RT-PCR analysis of hepatic (L) αSMA and (M) TNF-α transcript levels measured at the end of the 16 week experiments. Data are presented as mean ± SEM; n = 5-7 mice per group. Hashtags indicate significant differences ( p

    Article Snippet: Serological analysis Blood obtained by cardiac puncture was collected for measurements of serum alanine aminotransferase (ALT), and aspartate aminotransferase (AST) concentrations using an AST and ALT Activity Assay Kit (Sigma-Aldrich, St. Louis, MO).

    Techniques: Mouse Assay, Staining, AST Assay, Quantitative RT-PCR

    Serum determinations and histology from control or fibrotic mice treated with SR1664 or vehicle. ( A ) Serum adiponectin levels; ( B , C ) Serum ALT and AST levels; ( D ) Total body weight; ( E ) Liver weight expressed as percent total body weight; ( F ) Hematoxylin and eosin staining of liver sections. Bar = 200 µm; mean ± S.E.M; n = 6; * p

    Journal: Biology

    Article Title: A Selective PPARγ Modulator Reduces Hepatic Fibrosis

    doi: 10.3390/biology9070151

    Figure Lengend Snippet: Serum determinations and histology from control or fibrotic mice treated with SR1664 or vehicle. ( A ) Serum adiponectin levels; ( B , C ) Serum ALT and AST levels; ( D ) Total body weight; ( E ) Liver weight expressed as percent total body weight; ( F ) Hematoxylin and eosin staining of liver sections. Bar = 200 µm; mean ± S.E.M; n = 6; * p

    Article Snippet: Serum and tissue determinations: Serum alanine transaminase (ALT) and aspartate transaminase (AST) were measured by the VA Nebraska-Western Iowa Health Care System’s Clinical Chemistry Service using standard assays.

    Techniques: Mouse Assay, AST Assay, Staining

    PZH has no significant toxicity in EAE rats. (a) The organ coefficient of several organs from the respective group was detected. The levels of ALT (b) and AST (c) for hepatotoxicity as well as CREA (d) and UREA (e) for nephrotoxicity were shown, respectively.

    Journal: Journal of Immunology Research

    Article Title: Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat

    doi: 10.1155/2018/2952471

    Figure Lengend Snippet: PZH has no significant toxicity in EAE rats. (a) The organ coefficient of several organs from the respective group was detected. The levels of ALT (b) and AST (c) for hepatotoxicity as well as CREA (d) and UREA (e) for nephrotoxicity were shown, respectively.

    Article Snippet: Blood Biochemical Determination For the detection of hematological biochemical parameters, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CREA), and UREA nitrogen (UREA) were tested with blood biochemical commercial kits by a Japan's Hitachi 7160 automatic biochemical analyzer.

    Techniques: AST Assay

    Propofol post‐conditioning attenuated liver injury in donor liver. ( A ) Liver tissues were stained with H E, the pathology was observed under microscope (×400). ( B ) Immunofluorescence staining was performed with Nrf2 antibody, nuclei were stained with DAPI . ( C ) Suzike's injury score for liver damage degree. ( D ) Nucleus‐positive cells percentage of Nrf2. ( E – H ) Levels of aspartate aminotransferase ( AST ), alanine aminotransferase ( ALT ), prothrombin time ( PT ) and total bilirubin ( TBIL ) were measured preoperatively (base), at the end of the surgery (0 hrs), 6 hrs(6 hrs), 24 hrs(24 hrs), 2 days(2 days), 3 days(3 days), 5 days(5 days), 7 days(7 days) and 14 days(14 days) after surgery. The abnormally distribution data were expressed as median * P

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Propofol post‐conditioning alleviates hepatic ischaemia reperfusion injury via BRG1‐mediated Nrf2/ HO‐1 transcriptional activation in human and mice

    doi: 10.1111/jcmm.13279

    Figure Lengend Snippet: Propofol post‐conditioning attenuated liver injury in donor liver. ( A ) Liver tissues were stained with H E, the pathology was observed under microscope (×400). ( B ) Immunofluorescence staining was performed with Nrf2 antibody, nuclei were stained with DAPI . ( C ) Suzike's injury score for liver damage degree. ( D ) Nucleus‐positive cells percentage of Nrf2. ( E – H ) Levels of aspartate aminotransferase ( AST ), alanine aminotransferase ( ALT ), prothrombin time ( PT ) and total bilirubin ( TBIL ) were measured preoperatively (base), at the end of the surgery (0 hrs), 6 hrs(6 hrs), 24 hrs(24 hrs), 2 days(2 days), 3 days(3 days), 5 days(5 days), 7 days(7 days) and 14 days(14 days) after surgery. The abnormally distribution data were expressed as median * P

    Article Snippet: Liver function assessment Blood samples from patients and animals were centrifuged (1500 g, 15 min., 4°C), and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined by a 7180 Biochemical Analyzer (Hitachi, Japan).

    Techniques: Staining, Microscopy, Immunofluorescence, AST Assay

    Propofol attenuated liver IR injury and up‐regulated the expression of BRG 1, Nrf2, HO ‐1 and NQO 1 in mice. ( A ) Liver tissues of mice that were subjected to hepatic ischaemia reperfusion and treated with propofol were stained with H E and observed under microscope (×100). ( B – D ) The levels of AST , ALT and 8‐isoprostane were measured. ( E – H ) The expressions of Brg1, Nrf2, HO ‐1 and NQO 1 were assessed by Western blot. * P

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Propofol post‐conditioning alleviates hepatic ischaemia reperfusion injury via BRG1‐mediated Nrf2/ HO‐1 transcriptional activation in human and mice

    doi: 10.1111/jcmm.13279

    Figure Lengend Snippet: Propofol attenuated liver IR injury and up‐regulated the expression of BRG 1, Nrf2, HO ‐1 and NQO 1 in mice. ( A ) Liver tissues of mice that were subjected to hepatic ischaemia reperfusion and treated with propofol were stained with H E and observed under microscope (×100). ( B – D ) The levels of AST , ALT and 8‐isoprostane were measured. ( E – H ) The expressions of Brg1, Nrf2, HO ‐1 and NQO 1 were assessed by Western blot. * P

    Article Snippet: Liver function assessment Blood samples from patients and animals were centrifuged (1500 g, 15 min., 4°C), and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined by a 7180 Biochemical Analyzer (Hitachi, Japan).

    Techniques: Expressing, Mouse Assay, Staining, Microscopy, AST Assay, Western Blot

    Lactobacillus reuteri GMNL-263 improves liver injury and oxidative stress in high-fructose-diet rats. Effects of Lactobacillus reuteri GMNL-263 on expressions of liver injury markers (AST and ALT) ( A ), hepatic enzymatic activities of antioxidant (SOD and GR) ( B ), and pro-inflammatory cytokines (TNF-α and IL-6) ( C ) in high-fructose-diet rats at the end of the experimental period (14 weeks). The data were expressed as mean ± SD (n = 6). SOD, speroxide dismutase; GR, glutathione reductase. AST, aspartate aminotransferase; ALT, alanine aminotransferase; TNF-α, tumor necrosis factorα; IL-6, interleukin 6. #p

    Journal: Nutrition & Metabolism

    Article Title: Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats

    doi: 10.1186/1743-7075-10-35

    Figure Lengend Snippet: Lactobacillus reuteri GMNL-263 improves liver injury and oxidative stress in high-fructose-diet rats. Effects of Lactobacillus reuteri GMNL-263 on expressions of liver injury markers (AST and ALT) ( A ), hepatic enzymatic activities of antioxidant (SOD and GR) ( B ), and pro-inflammatory cytokines (TNF-α and IL-6) ( C ) in high-fructose-diet rats at the end of the experimental period (14 weeks). The data were expressed as mean ± SD (n = 6). SOD, speroxide dismutase; GR, glutathione reductase. AST, aspartate aminotransferase; ALT, alanine aminotransferase; TNF-α, tumor necrosis factorα; IL-6, interleukin 6. #p

    Article Snippet: Biochemical parameters analysis Serum biochemical parameters including triglyceride (TG) (detection limit was 3 mg/dl), low density lipoprotein (LDL) (detection limit was 5 mg/dl), cholesterol (detection limit was 3 mg/dl), aspartate aminotransferase (AST) (detection limit was 0.04 U/dl), and alanine aminotransferase (ALT) (detection limit was 0.04 U/dl) were analyzed using an automatic clinical analyzer (Hitachi High-Technologies Corporation, Tokyo, Japan).

    Techniques: AST Assay

    Decoction of Hedyotis diffusa (HD) relieves the acute inflammation in hepatitis mouse. a Administration of HD decoction blocked LPS/GALN-induced up-regulation of mRNA levels of CXCL1, TNF-α, IL-1β, MIP-2. b The treatment of HD decoction reduced the expressed levels of TNF-α, IL-1β, IL-6 and MCP-1 in liver of LPS/GALN-injected mice. c Alanine transaminase (ALT) level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of ALT (n = 5). d Aspartate transaminase (AST) level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of AST (n = 5). e Survival of hepatitis mouse was measured after treatment of HD decoction (n = 20, per group) within 20 days. f Effect of HD on LPS/GALN-mediated liver histopathologic changes

    Journal: Chinese Medicine

    Article Title: Metabolic regulations of a decoction of Hedyotis diffusa in acute liver injury of mouse models

    doi: 10.1186/s13020-017-0159-4

    Figure Lengend Snippet: Decoction of Hedyotis diffusa (HD) relieves the acute inflammation in hepatitis mouse. a Administration of HD decoction blocked LPS/GALN-induced up-regulation of mRNA levels of CXCL1, TNF-α, IL-1β, MIP-2. b The treatment of HD decoction reduced the expressed levels of TNF-α, IL-1β, IL-6 and MCP-1 in liver of LPS/GALN-injected mice. c Alanine transaminase (ALT) level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of ALT (n = 5). d Aspartate transaminase (AST) level was measured in control or LPS/GALN- and LPS/GALN + HD-treated mouse. HD decoction significantly reduced the level of AST (n = 5). e Survival of hepatitis mouse was measured after treatment of HD decoction (n = 20, per group) within 20 days. f Effect of HD on LPS/GALN-mediated liver histopathologic changes

    Article Snippet: Measurement of serum alanine transaminase and aspartate transaminase activities Blood samples were centrifuged at 1500g for 20 min at 4 °C, and alanine transaminase (ALT) and aspartate transaminase (AST) activities in serum were measured by commercial kits from Randox Laboratories (UK).

    Techniques: Injection, Mouse Assay, AST Assay

    Effects of MOK pharmacopuncture on the changes of serological parameters in PTU-induced hyperthyroidism rats. MOK pharmacopuncture was subcutaneously administered once daily for 2 weeks, and the levels of (A) glucose, (B) triglyceride, (C) total cholesterol, (D) LDL-cholesterol, (E) AST, and (F) ALT in the sera of rats were measured by automatic blood biochemical analyzer. Data are presented as mean ± standard deviation (n=5 per each group). *P

    Journal: Experimental and Therapeutic Medicine

    Article Title: Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats

    doi: 10.3892/etm.2018.6190

    Figure Lengend Snippet: Effects of MOK pharmacopuncture on the changes of serological parameters in PTU-induced hyperthyroidism rats. MOK pharmacopuncture was subcutaneously administered once daily for 2 weeks, and the levels of (A) glucose, (B) triglyceride, (C) total cholesterol, (D) LDL-cholesterol, (E) AST, and (F) ALT in the sera of rats were measured by automatic blood biochemical analyzer. Data are presented as mean ± standard deviation (n=5 per each group). *P

    Article Snippet: Serum aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride (TG), and glucose levels were measured with an automated blood analyzer (FDC7000i; Fujifilm Corporation, Tokyo, Japan)) and an ELISA reader (ASYS Hitech GmbH, Eugendorf, Austria).

    Techniques: AST Assay, Standard Deviation

    Alterations in plasma levels of AST ( A ), ALT ( B ), and Lactate ( C ) in young (3-month-old) rats at 4 h after normal saline (Sham) or LPS (LPS) injection treated with normal saline (Vehicle) or [D-Arg 1 D-Phe 5 D-Trp 7 , 9 Leu 11 ]-substance P (D-SP). Data are

    Journal: Annals of surgery

    Article Title: GHRELIN HYPORESPONSIVENESS CONTRIBUTES TO AGING-RELATED HYPERINFLAMMATION IN SEPTIC SHOCK

    doi: 10.1097/SLA.0b013e3181ad85d6

    Figure Lengend Snippet: Alterations in plasma levels of AST ( A ), ALT ( B ), and Lactate ( C ) in young (3-month-old) rats at 4 h after normal saline (Sham) or LPS (LPS) injection treated with normal saline (Vehicle) or [D-Arg 1 D-Phe 5 D-Trp 7 , 9 Leu 11 ]-substance P (D-SP). Data are

    Article Snippet: Plasma concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, and bilirubin were determined by using assay kits according to the manufacturer’s instructions (Pointe Scientific, Lincoln Park, MI).

    Techniques: AST Assay, Injection

    Alterations in plasma levels of TNF-α ( A ), IL-6 ( B ), AST ( C ), and ALT ( D ) in aged (24-month-old) rats at 4 h after normal saline (Sham) or LPS (LPS) injection treated with normal saline (Vehicle), ghrelin (Ghrelin), growth hormone (GH), or ghrelin

    Journal: Annals of surgery

    Article Title: GHRELIN HYPORESPONSIVENESS CONTRIBUTES TO AGING-RELATED HYPERINFLAMMATION IN SEPTIC SHOCK

    doi: 10.1097/SLA.0b013e3181ad85d6

    Figure Lengend Snippet: Alterations in plasma levels of TNF-α ( A ), IL-6 ( B ), AST ( C ), and ALT ( D ) in aged (24-month-old) rats at 4 h after normal saline (Sham) or LPS (LPS) injection treated with normal saline (Vehicle), ghrelin (Ghrelin), growth hormone (GH), or ghrelin

    Article Snippet: Plasma concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, and bilirubin were determined by using assay kits according to the manufacturer’s instructions (Pointe Scientific, Lincoln Park, MI).

    Techniques: AST Assay, Injection

    Alterations in plasma levels of AST ( A ), ALT ( B ), total bilirubin ( C ), and lactate ( D ) in young (3-month-old) or aged (24-month-old) rats at 4 h after normal saline (Vehicle) or LPS (LPS) injection. Data are presented as means ± SE (n=5–6/group)

    Journal: Annals of surgery

    Article Title: GHRELIN HYPORESPONSIVENESS CONTRIBUTES TO AGING-RELATED HYPERINFLAMMATION IN SEPTIC SHOCK

    doi: 10.1097/SLA.0b013e3181ad85d6

    Figure Lengend Snippet: Alterations in plasma levels of AST ( A ), ALT ( B ), total bilirubin ( C ), and lactate ( D ) in young (3-month-old) or aged (24-month-old) rats at 4 h after normal saline (Vehicle) or LPS (LPS) injection. Data are presented as means ± SE (n=5–6/group)

    Article Snippet: Plasma concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, and bilirubin were determined by using assay kits according to the manufacturer’s instructions (Pointe Scientific, Lincoln Park, MI).

    Techniques: AST Assay, Injection

    Effects of the FoxO1 inhibitor (AS) and APN on serum AST, ALT, and TG. Serum AST, ALT, and TG were determined by kits (Stanbio Laboratory, TX, USA). Values are expressed as mean ± SD, n = 6/group. ∗ P

    Journal: Journal of Diabetes Research

    Article Title: Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats

    doi: 10.1155/2018/6254340

    Figure Lengend Snippet: Effects of the FoxO1 inhibitor (AS) and APN on serum AST, ALT, and TG. Serum AST, ALT, and TG were determined by kits (Stanbio Laboratory, TX, USA). Values are expressed as mean ± SD, n = 6/group. ∗ P

    Article Snippet: Serum total aspartate aminotransferase (AST), alanine aminotransferase (ALT), and triglyceride (TG) were determined using commercially available kits (Stanbio Laboratory, TX, USA), respectively.

    Techniques: AST Assay

    In-vivo VASP repression by siRNA dampens hepatic IR injury. A ) LDH-serum levels after hepatic IR in in-vivo targeted repression of VASP with siRNA (siVASP) or non-targeting siRNA (siSCR) B ) Correlating serum levels of AST and C ) ALT of siVASP and siSCR treated WT animals. D ) Representative TTC stained liversections of both groups. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic tissue of siVASP and siSCR treated animals (Data are shown as Mean ± SEM, n = 6, * P

    Journal: PLoS ONE

    Article Title: Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) Dampens Hepatic Ischemia-Reperfusion Injury

    doi: 10.1371/journal.pone.0029494

    Figure Lengend Snippet: In-vivo VASP repression by siRNA dampens hepatic IR injury. A ) LDH-serum levels after hepatic IR in in-vivo targeted repression of VASP with siRNA (siVASP) or non-targeting siRNA (siSCR) B ) Correlating serum levels of AST and C ) ALT of siVASP and siSCR treated WT animals. D ) Representative TTC stained liversections of both groups. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic tissue of siVASP and siSCR treated animals (Data are shown as Mean ± SEM, n = 6, * P

    Article Snippet: Tissue damage was determined through blood serum levels of lactate dehydrogenase (LDH) (Randox, Crumlin, United Kingdom), aspartate (AST) and alanine aminotransferase (ALT) (Teco Diagnostics, Anaheim, USA).

    Techniques: In Vivo, AST Assay, Staining

    Hematopoietic VASP repression reduces hepatic IR injury. A ) LDH-serum levels in chimeric animals ( VASP −/− →WT and WT→ VASP −/− ) and control transplanted animals after 30 minutes of hepatic ischemia followed by 3 hours reperfusion. B ) Correlating serum levels of AST and C ) ALT of the chimeric and control animals D ) Representative TTC stained liversections of ischemic tissue. E ) Representative histological images of infracted hepatic areas of infiltrated platelet-neutrophil complexes (neutrophil = blue; platelets = black) of chimeric animals ( VASP −/− →WT and WT→ VASP −/− ) and control transplanted (WT→WT and VASP −/− → VASP −/− ) animals (Data are shown as Mean ± SEM, n = 6, * P

    Journal: PLoS ONE

    Article Title: Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) Dampens Hepatic Ischemia-Reperfusion Injury

    doi: 10.1371/journal.pone.0029494

    Figure Lengend Snippet: Hematopoietic VASP repression reduces hepatic IR injury. A ) LDH-serum levels in chimeric animals ( VASP −/− →WT and WT→ VASP −/− ) and control transplanted animals after 30 minutes of hepatic ischemia followed by 3 hours reperfusion. B ) Correlating serum levels of AST and C ) ALT of the chimeric and control animals D ) Representative TTC stained liversections of ischemic tissue. E ) Representative histological images of infracted hepatic areas of infiltrated platelet-neutrophil complexes (neutrophil = blue; platelets = black) of chimeric animals ( VASP −/− →WT and WT→ VASP −/− ) and control transplanted (WT→WT and VASP −/− → VASP −/− ) animals (Data are shown as Mean ± SEM, n = 6, * P

    Article Snippet: Tissue damage was determined through blood serum levels of lactate dehydrogenase (LDH) (Randox, Crumlin, United Kingdom), aspartate (AST) and alanine aminotransferase (ALT) (Teco Diagnostics, Anaheim, USA).

    Techniques: AST Assay, Staining

    VASP phosphorylation on Ser 235 using ANP dampens hepatic IR injury. A ) LDH-serum levels in WT and VASP −/− animals after 30 minutes of hepatic ischemia followed by 3 hours reperfusion with infusion of saline (vehicle) or ANP during reperfusion. B ) Correlating serum levels of AST and C ) ALT of vehicle or ANP treated WT and VASP −/− animals. D ) Representative TTC stained liversections of ischemic tissue. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic liver lobes of vehicle or ANP treated WT and VASP −/− animals (Data are shown as Mean ± SEM, n = 6, * P

    Journal: PLoS ONE

    Article Title: Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) Dampens Hepatic Ischemia-Reperfusion Injury

    doi: 10.1371/journal.pone.0029494

    Figure Lengend Snippet: VASP phosphorylation on Ser 235 using ANP dampens hepatic IR injury. A ) LDH-serum levels in WT and VASP −/− animals after 30 minutes of hepatic ischemia followed by 3 hours reperfusion with infusion of saline (vehicle) or ANP during reperfusion. B ) Correlating serum levels of AST and C ) ALT of vehicle or ANP treated WT and VASP −/− animals. D ) Representative TTC stained liversections of ischemic tissue. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic liver lobes of vehicle or ANP treated WT and VASP −/− animals (Data are shown as Mean ± SEM, n = 6, * P

    Article Snippet: Tissue damage was determined through blood serum levels of lactate dehydrogenase (LDH) (Randox, Crumlin, United Kingdom), aspartate (AST) and alanine aminotransferase (ALT) (Teco Diagnostics, Anaheim, USA).

    Techniques: Aqueous Normal-phase Chromatography, AST Assay, Staining

    VASP phosphorylation on Ser 153 using PGE 1 dampens hepatic IR injury. A ) LDH-serum levels in WT and VASP −/− animals after 30 minutes of hepatic ischemia followed by 3 hours reperfusion with infusion of saline (vehicle) or PGE1 during reperfusion. B ) Correlating serum levels of AST and C ) ALT of vehicle or PGE1 treated WT and VASP −/− animals. D ) Representative TTC stained liversections of ischemic tissue. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic liver lobes of vehicle or PGE 1 treated WT and VASP −/− animals (Data are shown as Mean ± SEM, n = 6, * P

    Journal: PLoS ONE

    Article Title: Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) Dampens Hepatic Ischemia-Reperfusion Injury

    doi: 10.1371/journal.pone.0029494

    Figure Lengend Snippet: VASP phosphorylation on Ser 153 using PGE 1 dampens hepatic IR injury. A ) LDH-serum levels in WT and VASP −/− animals after 30 minutes of hepatic ischemia followed by 3 hours reperfusion with infusion of saline (vehicle) or PGE1 during reperfusion. B ) Correlating serum levels of AST and C ) ALT of vehicle or PGE1 treated WT and VASP −/− animals. D ) Representative TTC stained liversections of ischemic tissue. E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic liver lobes of vehicle or PGE 1 treated WT and VASP −/− animals (Data are shown as Mean ± SEM, n = 6, * P

    Article Snippet: Tissue damage was determined through blood serum levels of lactate dehydrogenase (LDH) (Randox, Crumlin, United Kingdom), aspartate (AST) and alanine aminotransferase (ALT) (Teco Diagnostics, Anaheim, USA).

    Techniques: AST Assay, Staining

    VASP −/− animals demonstrate reduced hepatic IR injury. A ) LDH-serum levels of VASP −/− and WT mice after 30 minutes ischemia and 3 hours reperfusion in U/L. B ) Correlating serum levels of AST and C ) ALT of VASP −/− and WT animals. D ) Representative TTC stained liversections of VASP −/− and WT animals E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic tissue of VASP −/− and WT animals (Data are shown as Mean ± SEM, n = 6, * P

    Journal: PLoS ONE

    Article Title: Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) Dampens Hepatic Ischemia-Reperfusion Injury

    doi: 10.1371/journal.pone.0029494

    Figure Lengend Snippet: VASP −/− animals demonstrate reduced hepatic IR injury. A ) LDH-serum levels of VASP −/− and WT mice after 30 minutes ischemia and 3 hours reperfusion in U/L. B ) Correlating serum levels of AST and C ) ALT of VASP −/− and WT animals. D ) Representative TTC stained liversections of VASP −/− and WT animals E ) Histological images of platelet-neutrophil complexes (neutrophil = blue; platelet = black) in tissue sections of ischemic tissue of VASP −/− and WT animals (Data are shown as Mean ± SEM, n = 6, * P

    Article Snippet: Tissue damage was determined through blood serum levels of lactate dehydrogenase (LDH) (Randox, Crumlin, United Kingdom), aspartate (AST) and alanine aminotransferase (ALT) (Teco Diagnostics, Anaheim, USA).

    Techniques: Mouse Assay, AST Assay, Staining

    SAA treatment blunted myocardial injury in response to pressure-overload. (A) H E staining shows myocyte morphology of right ventricle in the control, model, bosentan, and SAA (0.3, 1, 3 mg/kg)-treated groups. The original magnification of the big images was ×200, and that of small images was ×40. Arrows indicate cellular hypertrophy and disarranged cell bundles. (B–E) SAA and bosentan decreased serum level of AST, ALT, and NT-proBNP in PAH rats. Data are shown as mean±SEM ( n =6). * P

    Journal: Acta Pharmacologica Sinica

    Article Title: Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model

    doi: 10.1038/aps.2016.22

    Figure Lengend Snippet: SAA treatment blunted myocardial injury in response to pressure-overload. (A) H E staining shows myocyte morphology of right ventricle in the control, model, bosentan, and SAA (0.3, 1, 3 mg/kg)-treated groups. The original magnification of the big images was ×200, and that of small images was ×40. Arrows indicate cellular hypertrophy and disarranged cell bundles. (B–E) SAA and bosentan decreased serum level of AST, ALT, and NT-proBNP in PAH rats. Data are shown as mean±SEM ( n =6). * P

    Article Snippet: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) kits were purchased from BioSino Biotechnology & Science Inc (Beijing, China).

    Techniques: Staining, AST Assay

    In vivo antitumor activity, pharmacokinetics and safety of Db10-Glyco-scTRAIL-FAVS G AA. (A) Colo205-bearing nude mice received 8 i.v. injections of the Db10-Glyco-scTRAIL-FAVS G AA fusion protein (0.1 nmol, 0.3 nmol, or 1.0 nmol) in combination with 8 intraperitoneal (i.p.) injections of bortezomib (Brt; 5µg per injection) every day indicated by dots. Mean ± 95% CI (n = 12 tumors per group). The 1.0 nmol-treated group received an identical regime of Db10-Glyco-scTRAIL-FAVS G AA and bortezomib after regrowth of tumors (volume ∼100 mm 3 ). Therefore, animals were divided into 2 subgroups of fast (I) and slow (II) regrowth. (B, C) Db10-Glyco-scTRAIL-FAVS G AA (168 µg per animal in B / 25 µg per animal in C) was injected i.v. into Colo205-bearing nude mice (B) or CD-1 mice (C). The serum concentrations of the fusion protein were analyzed via ELISA. Mean ± SD (n = 3). (D, E) Activity of alanine aminotransferase (ALT, D) and α-amylase (E) was measured after 4 hours (only for D), 1 day, and 9 d after the first of total 8 injections (every day) of Db10-Glyco-scTRAIL-FAVS G AA (0.1 nmol, 0.3 nmol, or 1.0 nmol; i.v.) and/or bortezomib (Brt, 5 µg; i.p.). Control mice were non-treated. Mean ± SD (n = 3).

    Journal: mAbs

    Article Title: An optimized antibody-single-chain TRAIL fusion protein for cancer therapy

    doi: 10.1080/19420862.2016.1172163

    Figure Lengend Snippet: In vivo antitumor activity, pharmacokinetics and safety of Db10-Glyco-scTRAIL-FAVS G AA. (A) Colo205-bearing nude mice received 8 i.v. injections of the Db10-Glyco-scTRAIL-FAVS G AA fusion protein (0.1 nmol, 0.3 nmol, or 1.0 nmol) in combination with 8 intraperitoneal (i.p.) injections of bortezomib (Brt; 5µg per injection) every day indicated by dots. Mean ± 95% CI (n = 12 tumors per group). The 1.0 nmol-treated group received an identical regime of Db10-Glyco-scTRAIL-FAVS G AA and bortezomib after regrowth of tumors (volume ∼100 mm 3 ). Therefore, animals were divided into 2 subgroups of fast (I) and slow (II) regrowth. (B, C) Db10-Glyco-scTRAIL-FAVS G AA (168 µg per animal in B / 25 µg per animal in C) was injected i.v. into Colo205-bearing nude mice (B) or CD-1 mice (C). The serum concentrations of the fusion protein were analyzed via ELISA. Mean ± SD (n = 3). (D, E) Activity of alanine aminotransferase (ALT, D) and α-amylase (E) was measured after 4 hours (only for D), 1 day, and 9 d after the first of total 8 injections (every day) of Db10-Glyco-scTRAIL-FAVS G AA (0.1 nmol, 0.3 nmol, or 1.0 nmol; i.v.) and/or bortezomib (Brt, 5 µg; i.p.). Control mice were non-treated. Mean ± SD (n = 3).

    Article Snippet: The activity of alanine aminotransferase (ALT) and α-amylase were measured using an enzymatic assay kit (abcam) according to the manufacturer's instructions.

    Techniques: In Vivo, Activity Assay, Mouse Assay, Injection, Enzyme-linked Immunosorbent Assay

    Time-dependent changes of serum ALT, ALP and LPCs after LCA exposure

    Journal: Hepatology (Baltimore, Md.)

    Article Title: Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis

    doi: 10.1002/hep.24193

    Figure Lengend Snippet: Time-dependent changes of serum ALT, ALP and LPCs after LCA exposure

    Article Snippet: The serum catalytic activity of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) was measured with ALT and ALP assay kit, respectively (Catachem, Bridgeport, CT).

    Techniques: ALP Assay

    Galectin-3 and liver damage marker correlation. Correlations were analyzed between galectin-3 and markers of liver damage in the group of patients with end-stage renal disease and hepatitis C viral infection. Based on r value, correlation can be positive or negative and weak ( r = 0.1–0.3), moderate ( r = 0.3–0.5), and strong ( r > 0.5). (a, b) Moderate negative correlation was obtained between galectin-3 and AST as well as galectin-3 and ALT in ESRD HCV + patients.

    Journal: Disease Markers

    Article Title: Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients

    doi: 10.1155/2017/6275987

    Figure Lengend Snippet: Galectin-3 and liver damage marker correlation. Correlations were analyzed between galectin-3 and markers of liver damage in the group of patients with end-stage renal disease and hepatitis C viral infection. Based on r value, correlation can be positive or negative and weak ( r = 0.1–0.3), moderate ( r = 0.3–0.5), and strong ( r > 0.5). (a, b) Moderate negative correlation was obtained between galectin-3 and AST as well as galectin-3 and ALT in ESRD HCV + patients.

    Article Snippet: Evaluation of Biochemical Parameters in Sera Serum levels of urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were routinely determined by standard methods suggested by the IFCC (International Federation for Clinical Chemistry and Laboratory Medicine) in the Central Biochemical Laboratory of the University Hospital of Foca, Bosnia and Herzegovina.

    Techniques: Marker, Infection, AST Assay

    Transplantation of OSKP-iPSC-Heps alleviated steatohepatitis in 18-month-old male MCD diet-fed mouse ( A ) Time course of the changes in serum ALT levels among control diet-fed mice, MCDD-fed mice, and MCDD-fed mice with intrasplenic transplantation of OSKP-iPSC-Heps or SnHeps. ( B ) H E staining showing the fat accumulation and severe hepatocyte vacuolization over the liver from MCDD-fed mice. Effect of intrasplenic transplantation of OSKP-iPSC-Heps or SnHeps on serum ( C ) ALT and ( D ) AST levels, and ( E ) hepatic triglyceride accumulation in MCDD-fed mice. In Panels C, D and E, * P

    Journal: Oncotarget

    Article Title: Improvement of non-alcoholic steatohepatitis by hepatocyte-like cells generated from iPSCs with Oct4/Sox2/Klf4/Parp1

    doi: 10.18632/oncotarget.23603

    Figure Lengend Snippet: Transplantation of OSKP-iPSC-Heps alleviated steatohepatitis in 18-month-old male MCD diet-fed mouse ( A ) Time course of the changes in serum ALT levels among control diet-fed mice, MCDD-fed mice, and MCDD-fed mice with intrasplenic transplantation of OSKP-iPSC-Heps or SnHeps. ( B ) H E staining showing the fat accumulation and severe hepatocyte vacuolization over the liver from MCDD-fed mice. Effect of intrasplenic transplantation of OSKP-iPSC-Heps or SnHeps on serum ( C ) ALT and ( D ) AST levels, and ( E ) hepatic triglyceride accumulation in MCDD-fed mice. In Panels C, D and E, * P

    Article Snippet: Serum ammonia and biochemical parameters, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) were analyzed using a Vitro DT chemistry system (Johnson & Johnson).

    Techniques: Transplantation Assay, Mouse Assay, Staining, AST Assay

    Mean postoperative changes in serum AST (A) and ALT (B). Changes from day of surgery (D0) to Day 6 after surgery (D6) in the septic (S) and nonseptic (NS) groups. There are significant differences between the S and NS groups from as early as the day after surgery. * indicates p

    Journal: BMC Anesthesiology

    Article Title: Early diagnostic markers of sepsis after oesophagectomy (including thromboelastography)

    doi: 10.1186/1471-2253-12-12

    Figure Lengend Snippet: Mean postoperative changes in serum AST (A) and ALT (B). Changes from day of surgery (D0) to Day 6 after surgery (D6) in the septic (S) and nonseptic (NS) groups. There are significant differences between the S and NS groups from as early as the day after surgery. * indicates p

    Article Snippet: Samples were analysed for: PCT (Elecsys BRAHMS PCT; Roche Diagnostics, Mannheim, Germany); IL- 6 (EIA IL-6; IMMUNOTECH, Marseille, France); lactate (Cobas Integra 400+; Roche, Switzerland); CRP, aspartate transaminase (AST) and alanine transaminase (ALT) (all Advia 1800; Siemens, USA).

    Techniques: AST Assay

    Liver enzyme ( A ) DB extract attenuated the increase of ALT compared with HFD. ( B ) AST was not increased in HFD compared with ND. Statistical analysis was performed using ANOVA and post hoc analysis using Tukey’s B analysis. Values with different letters are significantly different (P

    Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

    Article Title: Dioscorea batatas Extract Attenuates High-Fat Diet-Induced Obesity in Mice by Decreasing Expression of Inflammatory Cytokines

    doi: 10.12659/MSM.891306

    Figure Lengend Snippet: Liver enzyme ( A ) DB extract attenuated the increase of ALT compared with HFD. ( B ) AST was not increased in HFD compared with ND. Statistical analysis was performed using ANOVA and post hoc analysis using Tukey’s B analysis. Values with different letters are significantly different (P

    Article Snippet: Biochemical analysis Plasma concentrations of triglycerides (TGs), total cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured using commercial kits (Asan Pharmaco Co., Seoul, Korea).

    Techniques: AST Assay

    Effects of LFE on hepatic steatosis in ob/ob mice. After 8 weeks of LFE administration, plasma levels of ALT and AST, and TG were determined using commercial kits (A). Liver tissues were frozen and tissue sections were stained with either H E or Oil Red O, and visualized under an optical microscope (B). Hepatic TG contents were measured using commercial kit (C). Plasma levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured using ELISA kits (D). Hepatic mRNA levels of IL-1β and IL-6 were measured (E). *P

    Journal: PLoS ONE

    Article Title: Suppression of Adipocyte Differentiation by Foenumoside B from Lysimachia foenum-graecum Is Mediated by PPARγ Antagonism

    doi: 10.1371/journal.pone.0155432

    Figure Lengend Snippet: Effects of LFE on hepatic steatosis in ob/ob mice. After 8 weeks of LFE administration, plasma levels of ALT and AST, and TG were determined using commercial kits (A). Liver tissues were frozen and tissue sections were stained with either H E or Oil Red O, and visualized under an optical microscope (B). Hepatic TG contents were measured using commercial kit (C). Plasma levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured using ELISA kits (D). Hepatic mRNA levels of IL-1β and IL-6 were measured (E). *P

    Article Snippet: After centrifugation at 8,000 rpm at 4°C for 5 min, serum levels of TG, alanine aminotransferase (ALT), and aspartate transaminase (AST) were analyzed using commercial kits (Cayman Chemical, Ann Arbor, MI).

    Techniques: Mouse Assay, AST Assay, Staining, Microscopy, Enzyme-linked Immunosorbent Assay

    Effects of LFE on hepatic steatosis in KKAy mice. After 8 weeks of LFE administration, plasma levels of ALT and AST, and TG were determined using commercial kits (A). Liver tissues were frozen and tissue sections were stained with H E or Oil Red O, and examined under an optical microscope (B). Hepatic TG contents were measured using commercial kit (C). Plasma levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured using ELISA kits (D). Hepatic mRNA levels of IL-1β and IL-6 were measured (E). *P

    Journal: PLoS ONE

    Article Title: Suppression of Adipocyte Differentiation by Foenumoside B from Lysimachia foenum-graecum Is Mediated by PPARγ Antagonism

    doi: 10.1371/journal.pone.0155432

    Figure Lengend Snippet: Effects of LFE on hepatic steatosis in KKAy mice. After 8 weeks of LFE administration, plasma levels of ALT and AST, and TG were determined using commercial kits (A). Liver tissues were frozen and tissue sections were stained with H E or Oil Red O, and examined under an optical microscope (B). Hepatic TG contents were measured using commercial kit (C). Plasma levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured using ELISA kits (D). Hepatic mRNA levels of IL-1β and IL-6 were measured (E). *P

    Article Snippet: After centrifugation at 8,000 rpm at 4°C for 5 min, serum levels of TG, alanine aminotransferase (ALT), and aspartate transaminase (AST) were analyzed using commercial kits (Cayman Chemical, Ann Arbor, MI).

    Techniques: Mouse Assay, AST Assay, Staining, Microscopy, Enzyme-linked Immunosorbent Assay