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    Alomone Labs tertiapin
    t-ACPD affects 2 distinct potassium currents. A : current-clamp recording from a UBC in acute cerebellar slice. <t>Tertiapin</t> depolarized the cells when delivered on top of t-ACPD, but never reversed the mGluR-induced blockade of firing (although full recovery was always obtained on t-ACPD washout). The plot in B shows the values of UBCs' membrane potential measured in the presence of t-ACPD and in the presence of both t-ACPD and tertiapin (at the time points indicated by the arrows in A ; the values were −96.9 ± 7 mV in t-ACPD and −89.5 ± 5.6 mV in t-ACPD + tertiapin, 7 cells, P
    Tertiapin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    tertiapin - by Bioz Stars, 2022-08
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    t-ACPD affects 2 distinct potassium currents. A : current-clamp recording from a UBC in acute cerebellar slice. Tertiapin depolarized the cells when delivered on top of t-ACPD, but never reversed the mGluR-induced blockade of firing (although full recovery was always obtained on t-ACPD washout). The plot in B shows the values of UBCs' membrane potential measured in the presence of t-ACPD and in the presence of both t-ACPD and tertiapin (at the time points indicated by the arrows in A ; the values were −96.9 ± 7 mV in t-ACPD and −89.5 ± 5.6 mV in t-ACPD + tertiapin, 7 cells, P

    Journal: Journal of Neurophysiology

    Article Title: Dynamic Metabotropic Control of Intrinsic Firing in Cerebellar Unipolar Brush Cells

    doi: 10.1152/jn.90533.2008

    Figure Lengend Snippet: t-ACPD affects 2 distinct potassium currents. A : current-clamp recording from a UBC in acute cerebellar slice. Tertiapin depolarized the cells when delivered on top of t-ACPD, but never reversed the mGluR-induced blockade of firing (although full recovery was always obtained on t-ACPD washout). The plot in B shows the values of UBCs' membrane potential measured in the presence of t-ACPD and in the presence of both t-ACPD and tertiapin (at the time points indicated by the arrows in A ; the values were −96.9 ± 7 mV in t-ACPD and −89.5 ± 5.6 mV in t-ACPD + tertiapin, 7 cells, P

    Article Snippet: Drugs and chemicals were from Sigma (St. Louis, MO), except 4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride (ZD7288), (2 S )-2-amino-2-[(1 S ,2 S )-2-carboxyxycloprop-1-yl]-3-(xanth-9-yl) propanoic acid , (±)-aminocyclopentane- trans -1,3-dicarboxylic acid (t-ACPD), (2 R ,4 R )-4-aminopyrrolidine-2,4-dicarboxylate [(2 R ,4 R )APDC; Tocris, Ellisville, MO], tetrodotoxin (TTX), and r-tertiapin (cat #RTT250; Alomone Labs, Jerusalem, Israel).

    Techniques:

    Intrinsic firing of UBCs is tertiapin insensitive. A : current-clamp recording from a UBC; bath application of tertiapin did not produce any significant effect on the firing frequency. Trace segments recorded in the absence and in the presence of tertiapin are shown in B on an expanded timescale. The plot in C summarizes the data obtained in 7 UBCs (the firing frequency was 8.5 ± 2 Hz in control and 8.0 ± 1.4 Hz in the presence of tertiapin).

    Journal: Journal of Neurophysiology

    Article Title: Dynamic Metabotropic Control of Intrinsic Firing in Cerebellar Unipolar Brush Cells

    doi: 10.1152/jn.90533.2008

    Figure Lengend Snippet: Intrinsic firing of UBCs is tertiapin insensitive. A : current-clamp recording from a UBC; bath application of tertiapin did not produce any significant effect on the firing frequency. Trace segments recorded in the absence and in the presence of tertiapin are shown in B on an expanded timescale. The plot in C summarizes the data obtained in 7 UBCs (the firing frequency was 8.5 ± 2 Hz in control and 8.0 ± 1.4 Hz in the presence of tertiapin).

    Article Snippet: Drugs and chemicals were from Sigma (St. Louis, MO), except 4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride (ZD7288), (2 S )-2-amino-2-[(1 S ,2 S )-2-carboxyxycloprop-1-yl]-3-(xanth-9-yl) propanoic acid , (±)-aminocyclopentane- trans -1,3-dicarboxylic acid (t-ACPD), (2 R ,4 R )-4-aminopyrrolidine-2,4-dicarboxylate [(2 R ,4 R )APDC; Tocris, Ellisville, MO], tetrodotoxin (TTX), and r-tertiapin (cat #RTT250; Alomone Labs, Jerusalem, Israel).

    Techniques: