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  • 96
    Cell Signaling Technology Inc jak2
    Systemic ketamine administration depresses evoked field potentials in the OFC, and this is prevented by inhibiting <t>JAK2</t> activity in the OFC. In rats receiving a microinjection of ACSF vehicle (0.5 μl) into OFC, a subsequent systemic saline injection had no effect on evoked LFP responses in the OFC (a), whereas systemic ketamine administration (10 mg/kg, i.p.) induced a depression of the evoked LFP response that emerged 30–60 min after injection and lasted for the duration of recording (b). Local microinjection of the JAK2 inhibitor AG490 into OFC prior to a systemic injection of saline had no effect on the evoked LFP alone (c), but prevented the ketamine-induced depression of the evoked LFP (d). Insets show representative traces recorded at the time points indicated. Data represent mean percent of baseline±SEM ( n =5/group).
    Jak2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2/product/Cell Signaling Technology Inc
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
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    97
    ABclonal hrp goat anti rabbit igg h l antibody
    Systemic ketamine administration depresses evoked field potentials in the OFC, and this is prevented by inhibiting <t>JAK2</t> activity in the OFC. In rats receiving a microinjection of ACSF vehicle (0.5 μl) into OFC, a subsequent systemic saline injection had no effect on evoked LFP responses in the OFC (a), whereas systemic ketamine administration (10 mg/kg, i.p.) induced a depression of the evoked LFP response that emerged 30–60 min after injection and lasted for the duration of recording (b). Local microinjection of the JAK2 inhibitor AG490 into OFC prior to a systemic injection of saline had no effect on the evoked LFP alone (c), but prevented the ketamine-induced depression of the evoked LFP (d). Insets show representative traces recorded at the time points indicated. Data represent mean percent of baseline±SEM ( n =5/group).
    Hrp Goat Anti Rabbit Igg H L Antibody, supplied by ABclonal, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hrp goat anti rabbit igg h l antibody/product/ABclonal
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    hrp goat anti rabbit igg h l antibody - by Bioz Stars, 2021-05
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    97
    Abcam anti ikb alpha antibody e130
    Systemic ketamine administration depresses evoked field potentials in the OFC, and this is prevented by inhibiting <t>JAK2</t> activity in the OFC. In rats receiving a microinjection of ACSF vehicle (0.5 μl) into OFC, a subsequent systemic saline injection had no effect on evoked LFP responses in the OFC (a), whereas systemic ketamine administration (10 mg/kg, i.p.) induced a depression of the evoked LFP response that emerged 30–60 min after injection and lasted for the duration of recording (b). Local microinjection of the JAK2 inhibitor AG490 into OFC prior to a systemic injection of saline had no effect on the evoked LFP alone (c), but prevented the ketamine-induced depression of the evoked LFP (d). Insets show representative traces recorded at the time points indicated. Data represent mean percent of baseline±SEM ( n =5/group).
    Anti Ikb Alpha Antibody E130, supplied by Abcam, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti ikb alpha antibody e130/product/Abcam
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
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    93
    Abcam anti eef1a1 antibody
    Systemic ketamine administration depresses evoked field potentials in the OFC, and this is prevented by inhibiting <t>JAK2</t> activity in the OFC. In rats receiving a microinjection of ACSF vehicle (0.5 μl) into OFC, a subsequent systemic saline injection had no effect on evoked LFP responses in the OFC (a), whereas systemic ketamine administration (10 mg/kg, i.p.) induced a depression of the evoked LFP response that emerged 30–60 min after injection and lasted for the duration of recording (b). Local microinjection of the JAK2 inhibitor AG490 into OFC prior to a systemic injection of saline had no effect on the evoked LFP alone (c), but prevented the ketamine-induced depression of the evoked LFP (d). Insets show representative traces recorded at the time points indicated. Data represent mean percent of baseline±SEM ( n =5/group).
    Anti Eef1a1 Antibody, supplied by Abcam, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti eef1a1 antibody/product/Abcam
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti eef1a1 antibody - by Bioz Stars, 2021-05
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    Image Search Results


    Systemic ketamine administration depresses evoked field potentials in the OFC, and this is prevented by inhibiting JAK2 activity in the OFC. In rats receiving a microinjection of ACSF vehicle (0.5 μl) into OFC, a subsequent systemic saline injection had no effect on evoked LFP responses in the OFC (a), whereas systemic ketamine administration (10 mg/kg, i.p.) induced a depression of the evoked LFP response that emerged 30–60 min after injection and lasted for the duration of recording (b). Local microinjection of the JAK2 inhibitor AG490 into OFC prior to a systemic injection of saline had no effect on the evoked LFP alone (c), but prevented the ketamine-induced depression of the evoked LFP (d). Insets show representative traces recorded at the time points indicated. Data represent mean percent of baseline±SEM ( n =5/group).

    Journal: Neuropsychopharmacology

    Article Title: Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

    doi: 10.1038/npp.2016.236

    Figure Lengend Snippet: Systemic ketamine administration depresses evoked field potentials in the OFC, and this is prevented by inhibiting JAK2 activity in the OFC. In rats receiving a microinjection of ACSF vehicle (0.5 μl) into OFC, a subsequent systemic saline injection had no effect on evoked LFP responses in the OFC (a), whereas systemic ketamine administration (10 mg/kg, i.p.) induced a depression of the evoked LFP response that emerged 30–60 min after injection and lasted for the duration of recording (b). Local microinjection of the JAK2 inhibitor AG490 into OFC prior to a systemic injection of saline had no effect on the evoked LFP alone (c), but prevented the ketamine-induced depression of the evoked LFP (d). Insets show representative traces recorded at the time points indicated. Data represent mean percent of baseline±SEM ( n =5/group).

    Article Snippet: Pharmacological inhibition of JAK2 affects both JAK and STAT activity, so we used siRNA in primary cortical neurons to determine whether JAK2/STAT3 regulation of Arc expression was due to JAK2 kinase activity or transcriptional activity of STAT3.

    Techniques: Activity Assay, Injection

    Ketamine administration induces phosphorylation of JAK2 and STAT3 in rat primary cortical neurons in culture, and blocking JAK2 but not STAT3 prevents ketamine-induced Arc expression. Ketamine administration (0.5 μM) induced phosphorylation of both JAK2 (a) and STAT3 (b) within 30 min of drug application (* p

    Journal: Neuropsychopharmacology

    Article Title: Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

    doi: 10.1038/npp.2016.236

    Figure Lengend Snippet: Ketamine administration induces phosphorylation of JAK2 and STAT3 in rat primary cortical neurons in culture, and blocking JAK2 but not STAT3 prevents ketamine-induced Arc expression. Ketamine administration (0.5 μM) induced phosphorylation of both JAK2 (a) and STAT3 (b) within 30 min of drug application (* p

    Article Snippet: Pharmacological inhibition of JAK2 affects both JAK and STAT activity, so we used siRNA in primary cortical neurons to determine whether JAK2/STAT3 regulation of Arc expression was due to JAK2 kinase activity or transcriptional activity of STAT3.

    Techniques: Blocking Assay, Expressing

    Phosphorylated JAK2 colocalizes with Arc. E18 rat cortical neurons (DIV 18) were stimulated with 0.5 μM ketamine or saline vehicle for 30 min prior to fixation and processing for immunofluorescence. Phosphorylated JAK2 (pJAK2) was colocalized with Arc in a subset of punctate structures in both vehicle- (a) and ketamine-treated (b) neurons. Arrowheads indicate puncta where the two proteins are colocalized. Full arrows indicate non-colocalized Arc or pJAK2. Bar=20 μm. (c) Quantification of colocalization of pJAK2 and Arc in vehicle- and ketamine-treated neurons. After ketamine stimulation, the percentage of pJAK2 signal colocalized with Arc increased (* p

    Journal: Neuropsychopharmacology

    Article Title: Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

    doi: 10.1038/npp.2016.236

    Figure Lengend Snippet: Phosphorylated JAK2 colocalizes with Arc. E18 rat cortical neurons (DIV 18) were stimulated with 0.5 μM ketamine or saline vehicle for 30 min prior to fixation and processing for immunofluorescence. Phosphorylated JAK2 (pJAK2) was colocalized with Arc in a subset of punctate structures in both vehicle- (a) and ketamine-treated (b) neurons. Arrowheads indicate puncta where the two proteins are colocalized. Full arrows indicate non-colocalized Arc or pJAK2. Bar=20 μm. (c) Quantification of colocalization of pJAK2 and Arc in vehicle- and ketamine-treated neurons. After ketamine stimulation, the percentage of pJAK2 signal colocalized with Arc increased (* p

    Article Snippet: Pharmacological inhibition of JAK2 affects both JAK and STAT activity, so we used siRNA in primary cortical neurons to determine whether JAK2/STAT3 regulation of Arc expression was due to JAK2 kinase activity or transcriptional activity of STAT3.

    Techniques: Immunofluorescence

    Ketamine corrects the CIC stress-induced cognitive deficit in reversal learning and activates the JAK2/STAT3 pathway in the OFC. (a) Experimental timeline. (b) CIC-stressed rats exhibited a cognitive deficit in reversal learning that was prevented by acute systemic injection of ketamine (10 mg/kg, i.p.) given 24 h prior to testing (* p

    Journal: Neuropsychopharmacology

    Article Title: Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

    doi: 10.1038/npp.2016.236

    Figure Lengend Snippet: Ketamine corrects the CIC stress-induced cognitive deficit in reversal learning and activates the JAK2/STAT3 pathway in the OFC. (a) Experimental timeline. (b) CIC-stressed rats exhibited a cognitive deficit in reversal learning that was prevented by acute systemic injection of ketamine (10 mg/kg, i.p.) given 24 h prior to testing (* p

    Article Snippet: Pharmacological inhibition of JAK2 affects both JAK and STAT activity, so we used siRNA in primary cortical neurons to determine whether JAK2/STAT3 regulation of Arc expression was due to JAK2 kinase activity or transcriptional activity of STAT3.

    Techniques: Injection

    Pharmacological inhibition of the JAK2/STAT3 pathway in the OFC prevents the beneficial effects of ketamine on reversal learning and induction of the plasticity-related protein Arc. (a) Systemic administration of the JAK2 inhibitor AG490 (10 mg/kg, i.p.) at the time of ketamine administration blocked the beneficial effect of ketamine on reversal learning in CIC-stressed rats, tested 24 h after injection (* p

    Journal: Neuropsychopharmacology

    Article Title: Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

    doi: 10.1038/npp.2016.236

    Figure Lengend Snippet: Pharmacological inhibition of the JAK2/STAT3 pathway in the OFC prevents the beneficial effects of ketamine on reversal learning and induction of the plasticity-related protein Arc. (a) Systemic administration of the JAK2 inhibitor AG490 (10 mg/kg, i.p.) at the time of ketamine administration blocked the beneficial effect of ketamine on reversal learning in CIC-stressed rats, tested 24 h after injection (* p

    Article Snippet: Pharmacological inhibition of JAK2 affects both JAK and STAT activity, so we used siRNA in primary cortical neurons to determine whether JAK2/STAT3 regulation of Arc expression was due to JAK2 kinase activity or transcriptional activity of STAT3.

    Techniques: Inhibition, Injection