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  • 93
    V&P Scientific microcentrifuge tubes
    Microcentrifuge Tubes, supplied by V&P Scientific, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Chem Impex International glycerol
    Glycerol, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Proteintech polyclonal rabbit anti pla2g7 antibody
    Polyclonal Rabbit Anti Pla2g7 Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Proteintech pla2g7
    The H6D increases membrane loading of ω-6 PUFAs and stimulates PLA2 activity in peripheral afferent neurons. ( a ) Heatmap of linoleic acid (LA) and arachidonic acid (AA)-esterified lipid species in lumbar DRG from male (♂) and female (♀) mice on either the H6D or L6D, n=3 mice/group. Lipid classes are designated atop the heatmap. Scale bar represents z-score transformations for each lipid species. ( b , c ) Total accumulation of ( b ) LA/AA and ( c ) lysophospholipids in lumbar DRG and spinal cord of mice on H6D and L6D. ****P<0.0001, ***P<0.001, **P<0.01 vs L6D, n=6 mice/group. ( d ) PLA2 isozyme expression in lumbar DRG, n=6 mice/group. ( e ) Schematic detailing changes to a fluorogenic BODIPY substrate following sn-2 bond cleavage by PLA2 enzymes. ( f ) PLA2 activity in DRG homogenates in response to pretreatment with vehicle (DMSO) or the <t>PLA2g7-selective</t> inhibitor, darapladib. ****P<0.0001 vs L6D vehicle, #### P<0.0001, ### P<0.001 vs L6D vehicle, $$$$ P<0.0001, $$$ P<0.001 vs H6D vehicle, n=3 mice/group. ( g ) Acute effects (30 min) of intraplantarly-injected darapladib on heat- and mechanical-evoked nociception. Bold lines represent group means ± SEM determined from individual animal responses (faint lines) before and after treatment, n=8-9 mice/group. ( h ) Withdrawal responses to heat and mechanical stimulation following daily intrathecal (i.t., q.d. × 3 days) injection with either scrambled or PLA2g7-directed siRNA, n=9-10 mice/group. ****P<0.0001, ***P<0.001 vs L6D. Bars represent group means ± SEM. Each symbol represents data from individual animals.
    Pla2g7, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Proteintech pafah ii antibody
    The H6D increases membrane loading of ω-6 PUFAs and stimulates PLA2 activity in peripheral afferent neurons. ( a ) Heatmap of linoleic acid (LA) and arachidonic acid (AA)-esterified lipid species in lumbar DRG from male (♂) and female (♀) mice on either the H6D or L6D, n=3 mice/group. Lipid classes are designated atop the heatmap. Scale bar represents z-score transformations for each lipid species. ( b , c ) Total accumulation of ( b ) LA/AA and ( c ) lysophospholipids in lumbar DRG and spinal cord of mice on H6D and L6D. ****P<0.0001, ***P<0.001, **P<0.01 vs L6D, n=6 mice/group. ( d ) PLA2 isozyme expression in lumbar DRG, n=6 mice/group. ( e ) Schematic detailing changes to a fluorogenic BODIPY substrate following sn-2 bond cleavage by PLA2 enzymes. ( f ) PLA2 activity in DRG homogenates in response to pretreatment with vehicle (DMSO) or the <t>PLA2g7-selective</t> inhibitor, darapladib. ****P<0.0001 vs L6D vehicle, #### P<0.0001, ### P<0.001 vs L6D vehicle, $$$$ P<0.0001, $$$ P<0.001 vs H6D vehicle, n=3 mice/group. ( g ) Acute effects (30 min) of intraplantarly-injected darapladib on heat- and mechanical-evoked nociception. Bold lines represent group means ± SEM determined from individual animal responses (faint lines) before and after treatment, n=8-9 mice/group. ( h ) Withdrawal responses to heat and mechanical stimulation following daily intrathecal (i.t., q.d. × 3 days) injection with either scrambled or PLA2g7-directed siRNA, n=9-10 mice/group. ****P<0.0001, ***P<0.001 vs L6D. Bars represent group means ± SEM. Each symbol represents data from individual animals.
    Pafah Ii Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    The H6D increases membrane loading of ω-6 PUFAs and stimulates PLA2 activity in peripheral afferent neurons. ( a ) Heatmap of linoleic acid (LA) and arachidonic acid (AA)-esterified lipid species in lumbar DRG from male (♂) and female (♀) mice on either the H6D or L6D, n=3 mice/group. Lipid classes are designated atop the heatmap. Scale bar represents z-score transformations for each lipid species. ( b , c ) Total accumulation of ( b ) LA/AA and ( c ) lysophospholipids in lumbar DRG and spinal cord of mice on H6D and L6D. ****P<0.0001, ***P<0.001, **P<0.01 vs L6D, n=6 mice/group. ( d ) PLA2 isozyme expression in lumbar DRG, n=6 mice/group. ( e ) Schematic detailing changes to a fluorogenic BODIPY substrate following sn-2 bond cleavage by PLA2 enzymes. ( f ) PLA2 activity in DRG homogenates in response to pretreatment with vehicle (DMSO) or the PLA2g7-selective inhibitor, darapladib. ****P<0.0001 vs L6D vehicle, #### P<0.0001, ### P<0.001 vs L6D vehicle, $$$$ P<0.0001, $$$ P<0.001 vs H6D vehicle, n=3 mice/group. ( g ) Acute effects (30 min) of intraplantarly-injected darapladib on heat- and mechanical-evoked nociception. Bold lines represent group means ± SEM determined from individual animal responses (faint lines) before and after treatment, n=8-9 mice/group. ( h ) Withdrawal responses to heat and mechanical stimulation following daily intrathecal (i.t., q.d. × 3 days) injection with either scrambled or PLA2g7-directed siRNA, n=9-10 mice/group. ****P<0.0001, ***P<0.001 vs L6D. Bars represent group means ± SEM. Each symbol represents data from individual animals.

    Journal: bioRxiv

    Article Title: Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

    doi: 10.1101/2020.05.15.077164

    Figure Lengend Snippet: The H6D increases membrane loading of ω-6 PUFAs and stimulates PLA2 activity in peripheral afferent neurons. ( a ) Heatmap of linoleic acid (LA) and arachidonic acid (AA)-esterified lipid species in lumbar DRG from male (♂) and female (♀) mice on either the H6D or L6D, n=3 mice/group. Lipid classes are designated atop the heatmap. Scale bar represents z-score transformations for each lipid species. ( b , c ) Total accumulation of ( b ) LA/AA and ( c ) lysophospholipids in lumbar DRG and spinal cord of mice on H6D and L6D. ****P<0.0001, ***P<0.001, **P<0.01 vs L6D, n=6 mice/group. ( d ) PLA2 isozyme expression in lumbar DRG, n=6 mice/group. ( e ) Schematic detailing changes to a fluorogenic BODIPY substrate following sn-2 bond cleavage by PLA2 enzymes. ( f ) PLA2 activity in DRG homogenates in response to pretreatment with vehicle (DMSO) or the PLA2g7-selective inhibitor, darapladib. ****P<0.0001 vs L6D vehicle, #### P<0.0001, ### P<0.001 vs L6D vehicle, $$$$ P<0.0001, $$$ P<0.001 vs H6D vehicle, n=3 mice/group. ( g ) Acute effects (30 min) of intraplantarly-injected darapladib on heat- and mechanical-evoked nociception. Bold lines represent group means ± SEM determined from individual animal responses (faint lines) before and after treatment, n=8-9 mice/group. ( h ) Withdrawal responses to heat and mechanical stimulation following daily intrathecal (i.t., q.d. × 3 days) injection with either scrambled or PLA2g7-directed siRNA, n=9-10 mice/group. ****P<0.0001, ***P<0.001 vs L6D. Bars represent group means ± SEM. Each symbol represents data from individual animals.

    Article Snippet: Primary antibodies included: PGP9.5 (1:1000; AB1761-1, Millipore), ATF3 (1:400; ab207434, Abcam), NeuN (1:500; ABN91, Millipore), NFH (1:5000; 822601, Biolegend), TRPV1 (1:700; GP14100, Neuromics), PLA2g7 (1:500; 15526-1-AP, ProteinTech), IB4 (1:800; I21411, ThermoFisher), GFRA2 (1:500; AF429, R&D Systems).

    Techniques: Activity Assay, Expressing, Injection