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  • 94
    Alomone Labs penitrem a
    Block of BK channels by other fungal alkaloids is also abolished by the G311S mutation. (A) A Slo1 G-V curve for activation with 10 µM Ca 2+ is plotted for currents measured in the absence and presence of 10 nM aflatrem ( n = 4 patches). (B) The time course of block by 10 nM aflatrem is shown for one patch. (C) 10 nM aflatrem is without effect on the G-V elicited by 10 µM Ca 2+ for the Slo1-G311S construct. (D) Over 4 min of application of 10 nM aflatrem produces no reduction in current of Slo1-G311S. (E) The effect of 10 nM <t>penitrem</t> A on the Slo1 G-V curve is plotted. (F) The time course of block of Slo1 by penitrem A is plotted. (G) 10 nM penitrem A is without effect on Slo1-G311S conductance. (H) Over 5 min of application of 10 nM penitrem A has no effect on Slo1-G311S current. (I) Block of the Slo1 G-V by 10 nM verruculogen is plotted. (J) The time course of verruculogen block is displayed. (K) 10 nM verruculogen is without effect on Slo1-G311S conductance. (L) Over 5 min of verruculogen application is without effect on Slo1-G311S current.
    Penitrem A, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/penitrem a/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
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    penitrem a - by Bioz Stars, 2022-08
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    86
    Endress+Hauser zeenit p650 spectrometer
    Block of BK channels by other fungal alkaloids is also abolished by the G311S mutation. (A) A Slo1 G-V curve for activation with 10 µM Ca 2+ is plotted for currents measured in the absence and presence of 10 nM aflatrem ( n = 4 patches). (B) The time course of block by 10 nM aflatrem is shown for one patch. (C) 10 nM aflatrem is without effect on the G-V elicited by 10 µM Ca 2+ for the Slo1-G311S construct. (D) Over 4 min of application of 10 nM aflatrem produces no reduction in current of Slo1-G311S. (E) The effect of 10 nM <t>penitrem</t> A on the Slo1 G-V curve is plotted. (F) The time course of block of Slo1 by penitrem A is plotted. (G) 10 nM penitrem A is without effect on Slo1-G311S conductance. (H) Over 5 min of application of 10 nM penitrem A has no effect on Slo1-G311S current. (I) Block of the Slo1 G-V by 10 nM verruculogen is plotted. (J) The time course of verruculogen block is displayed. (K) 10 nM verruculogen is without effect on Slo1-G311S conductance. (L) Over 5 min of verruculogen application is without effect on Slo1-G311S current.
    Zeenit P650 Spectrometer, supplied by Endress+Hauser, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/zeenit p650 spectrometer/product/Endress+Hauser
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    zeenit p650 spectrometer - by Bioz Stars, 2022-08
    86/100 stars
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    80
    Cytoskeleton Inc actin cytoskeleton
    Block of BK channels by other fungal alkaloids is also abolished by the G311S mutation. (A) A Slo1 G-V curve for activation with 10 µM Ca 2+ is plotted for currents measured in the absence and presence of 10 nM aflatrem ( n = 4 patches). (B) The time course of block by 10 nM aflatrem is shown for one patch. (C) 10 nM aflatrem is without effect on the G-V elicited by 10 µM Ca 2+ for the Slo1-G311S construct. (D) Over 4 min of application of 10 nM aflatrem produces no reduction in current of Slo1-G311S. (E) The effect of 10 nM <t>penitrem</t> A on the Slo1 G-V curve is plotted. (F) The time course of block of Slo1 by penitrem A is plotted. (G) 10 nM penitrem A is without effect on Slo1-G311S conductance. (H) Over 5 min of application of 10 nM penitrem A has no effect on Slo1-G311S current. (I) Block of the Slo1 G-V by 10 nM verruculogen is plotted. (J) The time course of verruculogen block is displayed. (K) 10 nM verruculogen is without effect on Slo1-G311S conductance. (L) Over 5 min of verruculogen application is without effect on Slo1-G311S current.
    Actin Cytoskeleton, supplied by Cytoskeleton Inc, used in various techniques. Bioz Stars score: 80/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/actin cytoskeleton/product/Cytoskeleton Inc
    Average 80 stars, based on 1 article reviews
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    actin cytoskeleton - by Bioz Stars, 2022-08
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    96
    JASCO Inc jasco p650 spectrometer
    Block of BK channels by other fungal alkaloids is also abolished by the G311S mutation. (A) A Slo1 G-V curve for activation with 10 µM Ca 2+ is plotted for currents measured in the absence and presence of 10 nM aflatrem ( n = 4 patches). (B) The time course of block by 10 nM aflatrem is shown for one patch. (C) 10 nM aflatrem is without effect on the G-V elicited by 10 µM Ca 2+ for the Slo1-G311S construct. (D) Over 4 min of application of 10 nM aflatrem produces no reduction in current of Slo1-G311S. (E) The effect of 10 nM <t>penitrem</t> A on the Slo1 G-V curve is plotted. (F) The time course of block of Slo1 by penitrem A is plotted. (G) 10 nM penitrem A is without effect on Slo1-G311S conductance. (H) Over 5 min of application of 10 nM penitrem A has no effect on Slo1-G311S current. (I) Block of the Slo1 G-V by 10 nM verruculogen is plotted. (J) The time course of verruculogen block is displayed. (K) 10 nM verruculogen is without effect on Slo1-G311S conductance. (L) Over 5 min of verruculogen application is without effect on Slo1-G311S current.
    Jasco P650 Spectrometer, supplied by JASCO Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jasco p650 spectrometer/product/JASCO Inc
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    jasco p650 spectrometer - by Bioz Stars, 2022-08
    96/100 stars
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    Image Search Results


    Block of BK channels by other fungal alkaloids is also abolished by the G311S mutation. (A) A Slo1 G-V curve for activation with 10 µM Ca 2+ is plotted for currents measured in the absence and presence of 10 nM aflatrem ( n = 4 patches). (B) The time course of block by 10 nM aflatrem is shown for one patch. (C) 10 nM aflatrem is without effect on the G-V elicited by 10 µM Ca 2+ for the Slo1-G311S construct. (D) Over 4 min of application of 10 nM aflatrem produces no reduction in current of Slo1-G311S. (E) The effect of 10 nM penitrem A on the Slo1 G-V curve is plotted. (F) The time course of block of Slo1 by penitrem A is plotted. (G) 10 nM penitrem A is without effect on Slo1-G311S conductance. (H) Over 5 min of application of 10 nM penitrem A has no effect on Slo1-G311S current. (I) Block of the Slo1 G-V by 10 nM verruculogen is plotted. (J) The time course of verruculogen block is displayed. (K) 10 nM verruculogen is without effect on Slo1-G311S conductance. (L) Over 5 min of verruculogen application is without effect on Slo1-G311S current.

    Journal: The Journal of General Physiology

    Article Title: Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix

    doi: 10.1085/jgp.201010403

    Figure Lengend Snippet: Block of BK channels by other fungal alkaloids is also abolished by the G311S mutation. (A) A Slo1 G-V curve for activation with 10 µM Ca 2+ is plotted for currents measured in the absence and presence of 10 nM aflatrem ( n = 4 patches). (B) The time course of block by 10 nM aflatrem is shown for one patch. (C) 10 nM aflatrem is without effect on the G-V elicited by 10 µM Ca 2+ for the Slo1-G311S construct. (D) Over 4 min of application of 10 nM aflatrem produces no reduction in current of Slo1-G311S. (E) The effect of 10 nM penitrem A on the Slo1 G-V curve is plotted. (F) The time course of block of Slo1 by penitrem A is plotted. (G) 10 nM penitrem A is without effect on Slo1-G311S conductance. (H) Over 5 min of application of 10 nM penitrem A has no effect on Slo1-G311S current. (I) Block of the Slo1 G-V by 10 nM verruculogen is plotted. (J) The time course of verruculogen block is displayed. (K) 10 nM verruculogen is without effect on Slo1-G311S conductance. (L) Over 5 min of verruculogen application is without effect on Slo1-G311S current.

    Article Snippet: Penitrem A and verruculogen were obtained from Alomone Laboratories, prepared as 1-mM stocks in 50% DMSO and used at 10 nM with 0.0005% DMSO.

    Techniques: Blocking Assay, Mutagenesis, Activation Assay, Construct