MYA-3624 Search Results


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  • 90
    Amplyx Pharmaceuticals apx001
    Kidney burdens in mice at 48 h after infection with C. albicans SC5314. Treatments without ABT pretreatment were administered by i.p. injection, i.e., <t>APX001</t> (APX) at 13 mg/kg once daily or 26 mg/kg once daily or vehicle control once daily ( n = 5 per group). Another 2 groups of mice ( n = 8 per group) were given oral pretreatment with 100 mg/kg ABT 2 h prior to each APX001 dosing (at 13 mg/kg once daily or 26 mg/kg once daily). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. P values of
    Apx001, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apx001/product/Amplyx Pharmaceuticals
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apx001 - by Bioz Stars, 2022-12
    90/100 stars
      Buy from Supplier

    90
    Amplyx Pharmaceuticals apx001a
    Kidney burdens in mice at 48 h after infection with C. albicans SC5314. Treatments without ABT pretreatment were administered by i.p. injection, i.e., <t>APX001</t> (APX) at 13 mg/kg once daily or 26 mg/kg once daily or vehicle control once daily ( n = 5 per group). Another 2 groups of mice ( n = 8 per group) were given oral pretreatment with 100 mg/kg ABT 2 h prior to each APX001 dosing (at 13 mg/kg once daily or 26 mg/kg once daily). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. P values of
    Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apx001a - by Bioz Stars, 2022-12
    90/100 stars
      Buy from Supplier

    80
    Astellas micafungin
    Kidney burdens in mice at 48 h after infection with C. glabrata ATCC 2001 (WT), DPL40 (ER), or DPL-d249 (MDR). Oral pretreatment with ABT was applied to all groups 2 h prior to each dosing. Once-daily i.p. treatments in each infection cohort were 26 mg/kg APX001 (APX), 5 mg/kg <t>micafungin,</t> or vehicle control ( n = 10 per group). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. Dead mice (3 infected with the ER strain and treated with micafungin, 2 infected with the MDR strain and treated with APX001, and 1 infected with the MDR strain and treated with micafungin) were excluded from statistical analyses. P values of
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 80/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 80 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2022-12
    80/100 stars
      Buy from Supplier

    94
    ATCC a fumigatus mya3626
    Kidney burdens in mice at 48 h after infection with C. glabrata ATCC 2001 (WT), DPL40 (ER), or DPL-d249 (MDR). Oral pretreatment with ABT was applied to all groups 2 h prior to each dosing. Once-daily i.p. treatments in each infection cohort were 26 mg/kg APX001 (APX), 5 mg/kg <t>micafungin,</t> or vehicle control ( n = 10 per group). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. Dead mice (3 infected with the ER strain and treated with micafungin, 2 infected with the MDR strain and treated with APX001, and 1 infected with the MDR strain and treated with micafungin) were excluded from statistical analyses. P values of
    A Fumigatus Mya3626, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/a fumigatus mya3626/product/ATCC
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    a fumigatus mya3626 - by Bioz Stars, 2022-12
    94/100 stars
      Buy from Supplier

    Image Search Results


    Kidney burdens in mice at 48 h after infection with C. albicans SC5314. Treatments without ABT pretreatment were administered by i.p. injection, i.e., APX001 (APX) at 13 mg/kg once daily or 26 mg/kg once daily or vehicle control once daily ( n = 5 per group). Another 2 groups of mice ( n = 8 per group) were given oral pretreatment with 100 mg/kg ABT 2 h prior to each APX001 dosing (at 13 mg/kg once daily or 26 mg/kg once daily). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. P values of

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

    doi: 10.1128/AAC.00425-18

    Figure Lengend Snippet: Kidney burdens in mice at 48 h after infection with C. albicans SC5314. Treatments without ABT pretreatment were administered by i.p. injection, i.e., APX001 (APX) at 13 mg/kg once daily or 26 mg/kg once daily or vehicle control once daily ( n = 5 per group). Another 2 groups of mice ( n = 8 per group) were given oral pretreatment with 100 mg/kg ABT 2 h prior to each APX001 dosing (at 13 mg/kg once daily or 26 mg/kg once daily). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. P values of

    Article Snippet: APX001A, APX001 (Amplyx Pharmaceuticals Inc., San Diego, CA, USA), and micafungin (Astellas Pharma Inc., Tokyo, Japan) were obtained as standard powders from their manufacturers.

    Techniques: Mouse Assay, Infection, Injection

    Kidney burdens in mice at 48 h after infection with C. glabrata ATCC 2001 (WT), DPL40 (ER), or DPL-d249 (MDR). Oral pretreatment with ABT was applied to all groups 2 h prior to each dosing. Once-daily i.p. treatments in each infection cohort were 26 mg/kg APX001 (APX), 5 mg/kg micafungin, or vehicle control ( n = 10 per group). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. Dead mice (3 infected with the ER strain and treated with micafungin, 2 infected with the MDR strain and treated with APX001, and 1 infected with the MDR strain and treated with micafungin) were excluded from statistical analyses. P values of

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

    doi: 10.1128/AAC.00425-18

    Figure Lengend Snippet: Kidney burdens in mice at 48 h after infection with C. glabrata ATCC 2001 (WT), DPL40 (ER), or DPL-d249 (MDR). Oral pretreatment with ABT was applied to all groups 2 h prior to each dosing. Once-daily i.p. treatments in each infection cohort were 26 mg/kg APX001 (APX), 5 mg/kg micafungin, or vehicle control ( n = 10 per group). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. Dead mice (3 infected with the ER strain and treated with micafungin, 2 infected with the MDR strain and treated with APX001, and 1 infected with the MDR strain and treated with micafungin) were excluded from statistical analyses. P values of

    Article Snippet: APX001A, APX001 (Amplyx Pharmaceuticals Inc., San Diego, CA, USA), and micafungin (Astellas Pharma Inc., Tokyo, Japan) were obtained as standard powders from their manufacturers.

    Techniques: Mouse Assay, Infection

    Kidney burdens in mice at 48 h after infection with C. glabrata ATCC 2001 (WT), DPL40 (ER), or DPL-d249 (MDR). Oral pretreatment with ABT was applied to all groups 2 h prior to each dosing. Once-daily i.p. treatments in each infection cohort were 26 mg/kg APX001 (APX), 5 mg/kg micafungin, or vehicle control ( n = 10 per group). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. Dead mice (3 infected with the ER strain and treated with micafungin, 2 infected with the MDR strain and treated with APX001, and 1 infected with the MDR strain and treated with micafungin) were excluded from statistical analyses. P values of

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

    doi: 10.1128/AAC.00425-18

    Figure Lengend Snippet: Kidney burdens in mice at 48 h after infection with C. glabrata ATCC 2001 (WT), DPL40 (ER), or DPL-d249 (MDR). Oral pretreatment with ABT was applied to all groups 2 h prior to each dosing. Once-daily i.p. treatments in each infection cohort were 26 mg/kg APX001 (APX), 5 mg/kg micafungin, or vehicle control ( n = 10 per group). Differences in kidney burdens among groups were assessed by ANOVA with the post hoc Dunn's test for multiple comparisons. Dead mice (3 infected with the ER strain and treated with micafungin, 2 infected with the MDR strain and treated with APX001, and 1 infected with the MDR strain and treated with micafungin) were excluded from statistical analyses. P values of

    Article Snippet: APX001A, APX001 (Amplyx Pharmaceuticals Inc., San Diego, CA, USA), and micafungin (Astellas Pharma Inc., Tokyo, Japan) were obtained as standard powders from their manufacturers.

    Techniques: Mouse Assay, Infection