Journal: Oxidative Medicine and Cellular Longevity
Article Title: Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells
Figure Lengend Snippet: Bavachin induces GSH depletion and lipid peroxidation accumulation in osteosarcoma (OS) cells. (a, b) Bavachin induces GSH depletion in a dose-related manner over 24 h. (c, d) Bavachin greatly induces ROS generation in OS cells over 24 h. (e, f) Bavachin increases MDA accumulation in a dose-related manner. (g, h) Western blotting analysis shows the expression of p-STAT3, STAT3, P53, SLC7A11, and GPX4 in OS cells treated with bavachin (10 μ M, 20 μ M, and 40 μ M) for 24 h. p
Article Snippet: Bavachin was purchased from MCE (China), and pifithrin-α (PFT-α), deferoxamine (DFO), ferrostatin-1 (Fer-1), and liproxstatin-1 (Lip-1) were purchased from Topscience (China).
Techniques: Multiple Displacement Amplification, Western Blot, Expressing