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  • 97
    Selleck Chemicals abt 737
    Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor <t>ABT-737</t> (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor ABT-263 (500 nM) for 5 hr.
    Abt 737, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/abt 737/product/Selleck Chemicals
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    abt 737 - by Bioz Stars, 2021-05
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    86
    Fisher Scientific lipofectamine 3000
    Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor <t>ABT-737</t> (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor ABT-263 (500 nM) for 5 hr.
    Lipofectamine 3000, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lipofectamine 3000/product/Fisher Scientific
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    lipofectamine 3000 - by Bioz Stars, 2021-05
    86/100 stars
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    97
    Selleck Chemicals navitoclax abt 263
    Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor <t>ABT-737</t> (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor <t>ABT-263</t> (500 nM) for 5 hr.
    Navitoclax Abt 263, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/navitoclax abt 263/product/Selleck Chemicals
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    navitoclax abt 263 - by Bioz Stars, 2021-05
    97/100 stars
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    96
    Selleck Chemicals dinaciclib sch727965
    Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor <t>ABT-737</t> (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor <t>ABT-263</t> (500 nM) for 5 hr.
    Dinaciclib Sch727965, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dinaciclib sch727965/product/Selleck Chemicals
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    dinaciclib sch727965 - by Bioz Stars, 2021-05
    96/100 stars
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    Image Search Results


    Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor ABT-737 (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor ABT-263 (500 nM) for 5 hr.

    Journal: eLife

    Article Title: MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

    doi: 10.7554/eLife.54954

    Figure Lengend Snippet: Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor ABT-737 (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor ABT-263 (500 nM) for 5 hr.

    Article Snippet: Erlotinib (#S7786), lapatinib (#S2111), dinaciclib (#S2768), cabozantinib (#S1119), ABT-263 (#S1001), ABT-737 (#S1002), and ABT-199 (#S8048) were from Selleck Chemicals.

    Techniques: Blocking Assay

    Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor ABT-737 (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor ABT-263 (500 nM) for 5 hr.

    Journal: eLife

    Article Title: MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

    doi: 10.7554/eLife.54954

    Figure Lengend Snippet: Mitochondria-targeted agents increase caspase-independent MCL1 degradation and synergize with BCLXL/BCL2 inhibitor to induce apoptosis. ( A ) LNCaP cells were pretreated with caspase inhibitor Z-DEVD-FMK (20 μM) for 1 hr, followed by treatment with CPI-613 (200 μM), gamitrinib-TPP (5 μM), or erlotinib (10 μM) and BCLXL/BCL2 inhibitor ABT-737 (5 μM) for 5 hr. Efficacy of caspase block by Z-DEVD-FMK was confirmed by blotting for caspase 3. ( B ) LNCaP were treated with actinonin with or without BCLXL/BCL2 inhibitor ABT-263 (500 nM) for 5 hr.

    Article Snippet: Erlotinib (#S7786), lapatinib (#S2111), dinaciclib (#S2768), cabozantinib (#S1119), ABT-263 (#S1001), ABT-737 (#S1002), and ABT-199 (#S8048) were from Selleck Chemicals.

    Techniques: Blocking Assay