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  • 93
    Toronto Research Chemicals dextromethorphan
    Inhibitory effect of positive control (PC), pluronic P85 (P85, black bar: 0.1% and gray bar: 1%) and tween 80 (black bar: 0.1% and gray bar: 1%) on ( A ) CYP1A2-mediated phenacetin O -deethylase, ( B ) CYP2C9-catalyzed diclofenac 4-hydroxylase, ( C ) CYP2C19-mediated mephenytoin 4-hydroxylase, ( D ) CYP2D6-mediated <t>dextromethorphan</t> demethylase, and ( E ) CYP3A-mediated midazolam 1-hydroxylase activities in ultra-pooled human liver microsomes in the presence of NADPH regenerating systems at 37 °C. ( F ) Inhibitory effects of P85 and tween 80 on the P-gp-mediated efflux of digoxin in LLC-PK1 cells that overexpress P-gp. Representative inhibitors for CYP isozymes and P-gp were used as PCs: 0.1 μM of α-Naphthoflavone (CYP1A2), 5 μM of sulfaphenazole (CYP2C9), 5 μM of S-benzylnirvanol (CYP2C19), 5 μM of quinidine (CYP2D6), 5 μM of ketoconazole (CYP3A), 25 μM of cyclosporine A (P-gp). The substrate concentrations for the CYP isozymes and P-gp were as follows: 50 μM of phenacetin (CYP1A2), 10 μM of diclofenac (CYP2C9), 100 μM of mephenytoin (CYP2C19), 5 μM of dextromethorphan (CYP2D6), 5 μM of midazolam (CYP3A), and 1 μM of [ 3 H]digoxin (P-gp). The data are expressed as means ± standard deviations ( n = 3). *: p < 0.05 and **: p < 0.01; statistically significant compared with control group by Student’s t -test.
    Dextromethorphan, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dextromethorphan/product/Toronto Research Chemicals
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    dextromethorphan - by Bioz Stars, 2024-06
    93/100 stars
      Buy from Supplier

    96
    MedChemExpress dexamethasone
    Inhibitory effect of positive control (PC), pluronic P85 (P85, black bar: 0.1% and gray bar: 1%) and tween 80 (black bar: 0.1% and gray bar: 1%) on ( A ) CYP1A2-mediated phenacetin O -deethylase, ( B ) CYP2C9-catalyzed diclofenac 4-hydroxylase, ( C ) CYP2C19-mediated mephenytoin 4-hydroxylase, ( D ) CYP2D6-mediated <t>dextromethorphan</t> demethylase, and ( E ) CYP3A-mediated midazolam 1-hydroxylase activities in ultra-pooled human liver microsomes in the presence of NADPH regenerating systems at 37 °C. ( F ) Inhibitory effects of P85 and tween 80 on the P-gp-mediated efflux of digoxin in LLC-PK1 cells that overexpress P-gp. Representative inhibitors for CYP isozymes and P-gp were used as PCs: 0.1 μM of α-Naphthoflavone (CYP1A2), 5 μM of sulfaphenazole (CYP2C9), 5 μM of S-benzylnirvanol (CYP2C19), 5 μM of quinidine (CYP2D6), 5 μM of ketoconazole (CYP3A), 25 μM of cyclosporine A (P-gp). The substrate concentrations for the CYP isozymes and P-gp were as follows: 50 μM of phenacetin (CYP1A2), 10 μM of diclofenac (CYP2C9), 100 μM of mephenytoin (CYP2C19), 5 μM of dextromethorphan (CYP2D6), 5 μM of midazolam (CYP3A), and 1 μM of [ 3 H]digoxin (P-gp). The data are expressed as means ± standard deviations ( n = 3). *: p < 0.05 and **: p < 0.01; statistically significant compared with control group by Student’s t -test.
    Dexamethasone, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dexamethasone/product/MedChemExpress
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    dexamethasone - by Bioz Stars, 2024-06
    96/100 stars
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    92
    Cerilliant Corporation dextromethorphan
    AEMS chronograms for the ejection of 1 µM <t>dextromethorphan</t> and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were triplicate ejections from the three sample wells.
    Dextromethorphan, supplied by Cerilliant Corporation, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dextromethorphan/product/Cerilliant Corporation
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    dextromethorphan - by Bioz Stars, 2024-06
    92/100 stars
      Buy from Supplier

    85
    Rockland Immunochemicals biotinylated species
    AEMS chronograms for the ejection of 1 µM <t>dextromethorphan</t> and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were triplicate ejections from the three sample wells.
    Biotinylated Species, supplied by Rockland Immunochemicals, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/biotinylated species/product/Rockland Immunochemicals
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    biotinylated species - by Bioz Stars, 2024-06
    85/100 stars
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    90
    ATCC glucocorticoid resistant mutant s49 1 tb 4 dex r 63 cells
    AEMS chronograms for the ejection of 1 µM <t>dextromethorphan</t> and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were triplicate ejections from the three sample wells.
    Glucocorticoid Resistant Mutant S49 1 Tb 4 Dex R 63 Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/glucocorticoid resistant mutant s49 1 tb 4 dex r 63 cells/product/ATCC
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    glucocorticoid resistant mutant s49 1 tb 4 dex r 63 cells - by Bioz Stars, 2024-06
    90/100 stars
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    Image Search Results


    Inhibitory effect of positive control (PC), pluronic P85 (P85, black bar: 0.1% and gray bar: 1%) and tween 80 (black bar: 0.1% and gray bar: 1%) on ( A ) CYP1A2-mediated phenacetin O -deethylase, ( B ) CYP2C9-catalyzed diclofenac 4-hydroxylase, ( C ) CYP2C19-mediated mephenytoin 4-hydroxylase, ( D ) CYP2D6-mediated dextromethorphan demethylase, and ( E ) CYP3A-mediated midazolam 1-hydroxylase activities in ultra-pooled human liver microsomes in the presence of NADPH regenerating systems at 37 °C. ( F ) Inhibitory effects of P85 and tween 80 on the P-gp-mediated efflux of digoxin in LLC-PK1 cells that overexpress P-gp. Representative inhibitors for CYP isozymes and P-gp were used as PCs: 0.1 μM of α-Naphthoflavone (CYP1A2), 5 μM of sulfaphenazole (CYP2C9), 5 μM of S-benzylnirvanol (CYP2C19), 5 μM of quinidine (CYP2D6), 5 μM of ketoconazole (CYP3A), 25 μM of cyclosporine A (P-gp). The substrate concentrations for the CYP isozymes and P-gp were as follows: 50 μM of phenacetin (CYP1A2), 10 μM of diclofenac (CYP2C9), 100 μM of mephenytoin (CYP2C19), 5 μM of dextromethorphan (CYP2D6), 5 μM of midazolam (CYP3A), and 1 μM of [ 3 H]digoxin (P-gp). The data are expressed as means ± standard deviations ( n = 3). *: p < 0.05 and **: p < 0.01; statistically significant compared with control group by Student’s t -test.

    Journal: Pharmaceutics

    Article Title: Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

    doi: 10.3390/pharmaceutics12090882

    Figure Lengend Snippet: Inhibitory effect of positive control (PC), pluronic P85 (P85, black bar: 0.1% and gray bar: 1%) and tween 80 (black bar: 0.1% and gray bar: 1%) on ( A ) CYP1A2-mediated phenacetin O -deethylase, ( B ) CYP2C9-catalyzed diclofenac 4-hydroxylase, ( C ) CYP2C19-mediated mephenytoin 4-hydroxylase, ( D ) CYP2D6-mediated dextromethorphan demethylase, and ( E ) CYP3A-mediated midazolam 1-hydroxylase activities in ultra-pooled human liver microsomes in the presence of NADPH regenerating systems at 37 °C. ( F ) Inhibitory effects of P85 and tween 80 on the P-gp-mediated efflux of digoxin in LLC-PK1 cells that overexpress P-gp. Representative inhibitors for CYP isozymes and P-gp were used as PCs: 0.1 μM of α-Naphthoflavone (CYP1A2), 5 μM of sulfaphenazole (CYP2C9), 5 μM of S-benzylnirvanol (CYP2C19), 5 μM of quinidine (CYP2D6), 5 μM of ketoconazole (CYP3A), 25 μM of cyclosporine A (P-gp). The substrate concentrations for the CYP isozymes and P-gp were as follows: 50 μM of phenacetin (CYP1A2), 10 μM of diclofenac (CYP2C9), 100 μM of mephenytoin (CYP2C19), 5 μM of dextromethorphan (CYP2D6), 5 μM of midazolam (CYP3A), and 1 μM of [ 3 H]digoxin (P-gp). The data are expressed as means ± standard deviations ( n = 3). *: p < 0.05 and **: p < 0.01; statistically significant compared with control group by Student’s t -test.

    Article Snippet: Phenacetin, S-mephenytoin, hydroxymephenytoin, dextromethorphan, dextrorphan, α-Naphthoflavone, sulfaphenazole, and S-benzylnirvanol were purchased from Toronto Research Chemicals (Toronto, ON, Canada).

    Techniques: Positive Control

    AEMS chronograms for the ejection of 1 µM dextromethorphan and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were triplicate ejections from the three sample wells.

    Journal: Metabolites

    Article Title: High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples

    doi: 10.3390/metabo11110789

    Figure Lengend Snippet: AEMS chronograms for the ejection of 1 µM dextromethorphan and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were triplicate ejections from the three sample wells.

    Article Snippet: Dextromethorphan, fentanyl, and fentanyl-D5 were acquired from Cerilliant (Round Rock, TX, USA).

    Techniques:

    AEMS chronograms for the ejection from in-well LLE samples of 1-pentanol (20 and 30 uL) and various solutions (25 uL), containing dextromethorphan and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were the triplicate ejections from the three sample wells.

    Journal: Metabolites

    Article Title: High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples

    doi: 10.3390/metabo11110789

    Figure Lengend Snippet: AEMS chronograms for the ejection from in-well LLE samples of 1-pentanol (20 and 30 uL) and various solutions (25 uL), containing dextromethorphan and adenosine in ( a ) water (red), ( b ) PBS (yellow), ( c ) water containing 1% PEG-400 (green), ( d ) water containing 200% CMC Triton X-100 (blue), and ( e ) urine (purple). The ejection volume was 1, 5, and 10 drops. There were nine ejections for each condition, which were the triplicate ejections from the three sample wells.

    Article Snippet: Dextromethorphan, fentanyl, and fentanyl-D5 were acquired from Cerilliant (Round Rock, TX, USA).

    Techniques: