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Image Search Results

Journal: The Journal of Neuroscience
Article Title: Cholecystokinin-Expressing Interneurons of the Medial Prefrontal Cortex Mediate Working Memory Retrieval
doi: 10.1523/JNEUROSCI.1919-19.2020
Figure Lengend Snippet: CCK-positive interneurons also release glutamate onto a subset of postsynaptic targets. A, Examples from a postsynaptic interneuron showing an EPSC (blue arrow) that consistently follows the onset of the light-evoked IPSC in successive light flashes. B, Glutamate receptor blockers CNQX and APV selectively inhibit the EPSC, leaving the IPSC intact. C, The further addition of a GABA-A receptor antagonist to the glutamate blockers eliminates the light-evoked postsynaptic responses completely. D, Histogram of latency from light onset demonstrates the respective timing of the light-evoked EPSCs (orange) and IPSCs (blue). The EPSCs occur later than the IPSCs but within 5–9 ms of light onset. E, Pie chart shows the relative proportions of cell types showing light-evoked EPSCs. Regular spiking (RS) interneurons are the most common type that show these light-evoked glutamatergic EPSCs, with examples also seen in a low threshold (LT) interneuron and in regular (RS) and burst spiking (BS) pyramidal (Pyr)neurons.
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