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    • asic subtypes  (Alomone Labs)
    93
    Alomone Labs asic subtypes
    Top, a schematic of acidic volatiles inhaled into the mouse nasal cavity. Bottom, <t>the</t> <t>MOE</t> on the top enlarged to the bottom with single OSN shown to the right. Acidic volatiles (e.g., acetic acid) are dissolved in mucosa and dissociated into protons (H+) and base (acetate). Based on our data, we propose that OSNs in the MOE can be stimulated by protons and base separately. While the base moiety initiates the conventional AC3-medaited cAMP pathway in olfactory cilia, protons directly activate ASICs expressed in the knob, dendrite, and soma, promoting the depolarization of OSNs. As ASICs are more widely expressed than individual subclass of receptor-specific OSNs, <t>ASIC</t> activation may unselectively depolarize different subclasses of OSNs, interfering with the anatomical logic of neural information transmission for specific odorants.
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    Top, a schematic of acidic volatiles inhaled into the mouse nasal cavity. Bottom, the MOE on the top enlarged to the bottom with single OSN shown to the right. Acidic volatiles (e.g., acetic acid) are dissolved in mucosa and dissociated into protons (H+) and base (acetate). Based on our data, we propose that OSNs in the MOE can be stimulated by protons and base separately. While the base moiety initiates the conventional AC3-medaited cAMP pathway in olfactory cilia, protons directly activate ASICs expressed in the knob, dendrite, and soma, promoting the depolarization of OSNs. As ASICs are more widely expressed than individual subclass of receptor-specific OSNs, ASIC activation may unselectively depolarize different subclasses of OSNs, interfering with the anatomical logic of neural information transmission for specific odorants.

    Journal: Molecular neurobiology

    Article Title: Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid-Sensing of Mouse Olfactory Sensory Neurons

    doi: 10.1007/s12035-020-01943-0

    Figure Lengend Snippet: Top, a schematic of acidic volatiles inhaled into the mouse nasal cavity. Bottom, the MOE on the top enlarged to the bottom with single OSN shown to the right. Acidic volatiles (e.g., acetic acid) are dissolved in mucosa and dissociated into protons (H+) and base (acetate). Based on our data, we propose that OSNs in the MOE can be stimulated by protons and base separately. While the base moiety initiates the conventional AC3-medaited cAMP pathway in olfactory cilia, protons directly activate ASICs expressed in the knob, dendrite, and soma, promoting the depolarization of OSNs. As ASICs are more widely expressed than individual subclass of receptor-specific OSNs, ASIC activation may unselectively depolarize different subclasses of OSNs, interfering with the anatomical logic of neural information transmission for specific odorants.

    Article Snippet: To examine whether other ASIC subtypes are expressed in the mouse MOE, we tested an anti-ASIC2 antibody (Catalog# ASC-012, Alomone Labs).

    Techniques: Activation Assay, Transmission Assay