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  • 94
    Alomone Labs anti kir2 1 primary antibody
    Anti Kir2 1 Primary Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Alomone Labs apc 026
    SERCA protein expression. When an mAb against SERCA1a (A52; ref. 14) was assayed, a specific band at about 100 kDa was observed in samples from <t>AdESERCA1-Kir2.1–injected</t> hearts, while no signal was detected in control heart samples. Interestingly, the density of the band correlates well with the amount of virus injected (1.6× vs. 1×). When a specific antibody against SERCA2 was assayed, the right band appeared in all heart samples (AdESERCA1-Kir2.1–injected and control) with the same magnitude. GP, guinea pig.
    Apc 026, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apc 026/product/Alomone Labs
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    86
    Alomone Labs rabbit polyclonal kir2 1 antibodies
    SERCA protein expression. When an mAb against SERCA1a (A52; ref. 14) was assayed, a specific band at about 100 kDa was observed in samples from <t>AdESERCA1-Kir2.1–injected</t> hearts, while no signal was detected in control heart samples. Interestingly, the density of the band correlates well with the amount of virus injected (1.6× vs. 1×). When a specific antibody against SERCA2 was assayed, the right band appeared in all heart samples (AdESERCA1-Kir2.1–injected and control) with the same magnitude. GP, guinea pig.
    Rabbit Polyclonal Kir2 1 Antibodies, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit polyclonal kir2 1 antibodies/product/Alomone Labs
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rabbit polyclonal kir2 1 antibodies - by Bioz Stars, 2023-01
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    85
    Alomone Labs hirk1
    SERCA protein expression. When an mAb against SERCA1a (A52; ref. 14) was assayed, a specific band at about 100 kDa was observed in samples from <t>AdESERCA1-Kir2.1–injected</t> hearts, while no signal was detected in control heart samples. Interestingly, the density of the band correlates well with the amount of virus injected (1.6× vs. 1×). When a specific antibody against SERCA2 was assayed, the right band appeared in all heart samples (AdESERCA1-Kir2.1–injected and control) with the same magnitude. GP, guinea pig.
    Hirk1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hirk1/product/Alomone Labs
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    86
    Alomone Labs kir2 3 proteins
    SERCA protein expression. When an mAb against SERCA1a (A52; ref. 14) was assayed, a specific band at about 100 kDa was observed in samples from <t>AdESERCA1-Kir2.1–injected</t> hearts, while no signal was detected in control heart samples. Interestingly, the density of the band correlates well with the amount of virus injected (1.6× vs. 1×). When a specific antibody against SERCA2 was assayed, the right band appeared in all heart samples (AdESERCA1-Kir2.1–injected and control) with the same magnitude. GP, guinea pig.
    Kir2 3 Proteins, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    SERCA protein expression. When an mAb against SERCA1a (A52; ref. 14) was assayed, a specific band at about 100 kDa was observed in samples from AdESERCA1-Kir2.1–injected hearts, while no signal was detected in control heart samples. Interestingly, the density of the band correlates well with the amount of virus injected (1.6× vs. 1×). When a specific antibody against SERCA2 was assayed, the right band appeared in all heart samples (AdESERCA1-Kir2.1–injected and control) with the same magnitude. GP, guinea pig.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: SERCA protein expression. When an mAb against SERCA1a (A52; ref. 14) was assayed, a specific band at about 100 kDa was observed in samples from AdESERCA1-Kir2.1–injected hearts, while no signal was detected in control heart samples. Interestingly, the density of the band correlates well with the amount of virus injected (1.6× vs. 1×). When a specific antibody against SERCA2 was assayed, the right band appeared in all heart samples (AdESERCA1-Kir2.1–injected and control) with the same magnitude. GP, guinea pig.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Expressing, Injection

    Intracellular Ca2+ transients. Representative Ca2+ transients elicited in control (a) and AdESERCA1-Kir2.1–infected myocytes (b) are shown. AdESERCA1-Kir2.1 infection increased the amplitude of the Indo-1 fluorescence ratio. (c) Average data are summarized (n = 5 for AdESERCA1-Kir2.1 group, and n = 8 for control). *P < 0.05, control versus S-K group, t test.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: Intracellular Ca2+ transients. Representative Ca2+ transients elicited in control (a) and AdESERCA1-Kir2.1–infected myocytes (b) are shown. AdESERCA1-Kir2.1 infection increased the amplitude of the Indo-1 fluorescence ratio. (c) Average data are summarized (n = 5 for AdESERCA1-Kir2.1 group, and n = 8 for control). *P < 0.05, control versus S-K group, t test.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Infection, Fluorescence

    Kir2.1 protein expression. (a) Western blot analysis using a polyclonal antibody against Kir2.1 protein. Although the specific band at approximately 42 kDa was present in both samples, its density was greater in the AdESERCA1-Kir2.1–injected guinea pig heart. (b) The relative expression of Kir2.1 normalized per actin protein for the same Western blot. Kir2.1 expression in the AdESERCA1-Kir2.1–injected heart was 30% higher than in control.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: Kir2.1 protein expression. (a) Western blot analysis using a polyclonal antibody against Kir2.1 protein. Although the specific band at approximately 42 kDa was present in both samples, its density was greater in the AdESERCA1-Kir2.1–injected guinea pig heart. (b) The relative expression of Kir2.1 normalized per actin protein for the same Western blot. Kir2.1 expression in the AdESERCA1-Kir2.1–injected heart was 30% higher than in control.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Expressing, Western Blot, Injection

    Inward rectifier K current (IK1). AdESERCA1-Kir2.1–infected myocytes showed a significant increase in IK1 amplitude at negative membrane potentials when compared with control myocytes (AdEGI-infected or noninfected cells). *P < 0.01, two-way ANOVA; n ≥ 8 for each point.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: Inward rectifier K current (IK1). AdESERCA1-Kir2.1–infected myocytes showed a significant increase in IK1 amplitude at negative membrane potentials when compared with control myocytes (AdEGI-infected or noninfected cells). *P < 0.01, two-way ANOVA; n ≥ 8 for each point.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Infection

    APD. (a and b) Representative action potentials elicited in control and AdESERCA1-Kir2.1–infected myocytes. AdESERCA1-Kir2.1 infection abbreviated the AP. (c) Average APD50 and APD90 data are summarized (n = 8 for AdESERCA1-Kir2.1 group, and n = 13 for control). *P < 0.05, AdESERCA1-Kir2.1 versus control, t test.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: APD. (a and b) Representative action potentials elicited in control and AdESERCA1-Kir2.1–infected myocytes. AdESERCA1-Kir2.1 infection abbreviated the AP. (c) Average APD50 and APD90 data are summarized (n = 8 for AdESERCA1-Kir2.1 group, and n = 13 for control). *P < 0.05, AdESERCA1-Kir2.1 versus control, t test.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Infection

    Widespread SERCA1 expression. Western blots from two different animals subjected to multiple-site injections of AdESERCA1-Kir2.1 throughout the left ventricle are shown. In both blots, the first lane corresponds to a homogenate of guinea pig skeletal muscle as a positive control for the SERCA1a-specific mAb A52 (14). Lanes 2 and 3 are the samples of the right ventricle, and lanes 4–9 correspond to each of six pieces into which the left ventricle was cut. Widespread expression of ectopic SERCA1a protein (∼100-kDa band) was obtained in the injected left ventricle, whereas no SERCA1a expression was observed in the noninjected right ventricle.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: Widespread SERCA1 expression. Western blots from two different animals subjected to multiple-site injections of AdESERCA1-Kir2.1 throughout the left ventricle are shown. In both blots, the first lane corresponds to a homogenate of guinea pig skeletal muscle as a positive control for the SERCA1a-specific mAb A52 (14). Lanes 2 and 3 are the samples of the right ventricle, and lanes 4–9 correspond to each of six pieces into which the left ventricle was cut. Widespread expression of ectopic SERCA1a protein (∼100-kDa band) was obtained in the injected left ventricle, whereas no SERCA1a expression was observed in the noninjected right ventricle.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Expressing, Western Blot, Positive Control, Injection

    ECG analysis: QTc interval. A significant reduction was observed in the QTc interval in AdESERCA1-Kir2.1–injected animals (black bars). No changes occurred in the animals treated with AdEGI. *P = 0.003, immediately after surgery versus 72 hours after injection and stimulation with GS-E, paired t test.

    Journal:

    Article Title: Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

    doi: 10.1172/JCI13359

    Figure Lengend Snippet: ECG analysis: QTc interval. A significant reduction was observed in the QTc interval in AdESERCA1-Kir2.1–injected animals (black bars). No changes occurred in the animals treated with AdEGI. *P = 0.003, immediately after surgery versus 72 hours after injection and stimulation with GS-E, paired t test.

    Article Snippet: The following antibodies were used: A52 ( 14 ) (monoclonal SERCA1a antibody, kindly provided by D. MacLennan, University of Toronto, Toronto, Ontario, Canada), MA3-910 (monoclonal SERCA2a antibody; Affinity BioReagents Inc., Golden, Colorado, USA), APC-026 (polyclonal anti-Kir2.1; Alomone Laboratories Ltd., Jerusalem, Israel) , and AC-40 (monoclonal anti-actin; Sigma Chemical Co. St. Louis, Missouri, USA).

    Techniques: Injection