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  • 94
    Alomone Labs rabbit anti na v 1 5
    Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.
    Rabbit Anti Na V 1 5, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit anti na v 1 5/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
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    rabbit anti na v 1 5 - by Bioz Stars, 2023-01
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    86
    Janssen acc 001
    Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.
    Acc 001, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/acc 001/product/Janssen
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    acc 001 - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Pfizer Inc acc 001
    Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.
    Acc 001, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/acc 001/product/Pfizer Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    acc 001 - by Bioz Stars, 2023-01
    86/100 stars
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    86
    Elan Drug Technologies acc 001
    Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.
    Acc 001, supplied by Elan Drug Technologies, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/acc 001/product/Elan Drug Technologies
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    acc 001 - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Pfizer Inc ntc00574132 acc 001 j j elan pfizer 2
    Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.
    Ntc00574132 Acc 001 J J Elan Pfizer 2, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ntc00574132 acc 001 j j elan pfizer 2/product/Pfizer Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ntc00574132 acc 001 j j elan pfizer 2 - by Bioz Stars, 2023-01
    86/100 stars
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    Image Search Results


    Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.

    Journal: International Journal of Molecular Sciences

    Article Title: Differences in Functional Expression of Connexin43 and Na V 1.5 by Pan- and Class-Selective Histone Deacetylase Inhibition in Heart

    doi: 10.3390/ijms19082288

    Figure Lengend Snippet: Changes in cardiac Cx43 and Na V 1.5 protein levels by panobinostat, entinostat and ricolinostat. ( A ) Representative Western blot of lysed NMVMs treated with 0, 25, 100, 500, and 2500 nM panobinostat for 24 h. Ac-tubulin is acetylated α-tubulin, Ac-H3 is acetylated histone 3, and α-tubulin was used as a loading control. ( B ) Densitometry scans of Cx43 Western blots ( n = 3) to quantify the reduction in Cx43 protein levels with increasing concentrations of panobinostat (* p < 0.05). ( C ) Densitometry scans of Na V 1.5 Western blots ( n = 3) quantifying the statistically significant decrease in Na V 1.5 protein levels with higher concentrations of panobinostat (* p < 0.05). ( D ) A representative Western blot of lysed ventricular myocytes treated with 1 μM entinostat (MS-275) or 25 nM ricolinostat for 24 h. Note that MS-275 only increased the Ac-H3 signal while ACY-1215 only increased the Ac-α-tubulin signal, consistent with their class I and HDAC6 inhibitory activities. ( E ) Densitometry scans of 1 μM entinostat Western blots ( n = 4) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with entinostat, a class I HDAC-selective inhibitor. ( F ) Densitometry scans of 25 nM ricolinostat Western blots ( n = 3) illustrating no significant changes in Cx43 or Na V 1.5 protein levels with ricolinostat.

    Article Snippet: Primary antibodies used in this study include rabbit anti-Cx43 (AB1728, Merck Millipore, Billerica, MA, USA), mouse anti-Cx43 (AB1727, Merck Millipore), mouse anti-α-tubulin (# T5168, Sigma-Aldrich, St. Louis, MO, USA), rabbit anti-acetylated H3 (# 06-599, Merck Millipore), rabbit anti-acetylated-α-tubulin (BML-SA452-0100, Enzo Life Sciences, Farmingdale, NY, USA) and rabbit anti-Na V 1.5 (# ACC-001, Alomone Labs, Jerusalem, Israel).

    Techniques: Western Blot