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  • 86
    Millipore glass beads
    Glass Beads, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore acid washed glass beads
    Acid Washed Glass Beads, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Takeda pioglitazone
    Effect of PIO on BK Ca channel activity in mHippoE-14 hippocampal neurons. (A) Original current traces of BK Ca channels obtained in the absence (left) and presence (right) of 10 μM <t>pioglitazone</t> (PIO). The examined cells were bathed in symmetrical K + solution (145 mM). Under inside-out current recordings, the potential was held at +60 mV and bath medium contained 0.1 μM Ca 2+ . The upward deflection represents the opening event of the channel. The lower part indicates the expanded trace recorded from the uppermost part in the control and during exposure to PIO. (B) BK Ca -channel trace obtained after washout of PIO. (C) Concentration-dependent increase in channel open probability (mean ± SEM; n = 9–11 for each point). Channel activity measured at +60 mV during the exposure to 100 μM PIO was taken to be 100%. The values for EC 50 , Hill coefficient and maximal percentage increase of BK Ca channels in the presence of PIO were 7.6 μM 1.3 and 100%, respectively.
    Pioglitazone, supplied by Takeda, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pioglitazone/product/Takeda
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    86
    Millipore pioglitazone
    Effect of PIO on BK Ca channel activity in mHippoE-14 hippocampal neurons. (A) Original current traces of BK Ca channels obtained in the absence (left) and presence (right) of 10 μM <t>pioglitazone</t> (PIO). The examined cells were bathed in symmetrical K + solution (145 mM). Under inside-out current recordings, the potential was held at +60 mV and bath medium contained 0.1 μM Ca 2+ . The upward deflection represents the opening event of the channel. The lower part indicates the expanded trace recorded from the uppermost part in the control and during exposure to PIO. (B) BK Ca -channel trace obtained after washout of PIO. (C) Concentration-dependent increase in channel open probability (mean ± SEM; n = 9–11 for each point). Channel activity measured at +60 mV during the exposure to 100 μM PIO was taken to be 100%. The values for EC 50 , Hill coefficient and maximal percentage increase of BK Ca channels in the presence of PIO were 7.6 μM 1.3 and 100%, respectively.
    Pioglitazone, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pioglitazone/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    pioglitazone - by Bioz Stars, 2022-01
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    Image Search Results


    Effect of PIO on BK Ca channel activity in mHippoE-14 hippocampal neurons. (A) Original current traces of BK Ca channels obtained in the absence (left) and presence (right) of 10 μM pioglitazone (PIO). The examined cells were bathed in symmetrical K + solution (145 mM). Under inside-out current recordings, the potential was held at +60 mV and bath medium contained 0.1 μM Ca 2+ . The upward deflection represents the opening event of the channel. The lower part indicates the expanded trace recorded from the uppermost part in the control and during exposure to PIO. (B) BK Ca -channel trace obtained after washout of PIO. (C) Concentration-dependent increase in channel open probability (mean ± SEM; n = 9–11 for each point). Channel activity measured at +60 mV during the exposure to 100 μM PIO was taken to be 100%. The values for EC 50 , Hill coefficient and maximal percentage increase of BK Ca channels in the presence of PIO were 7.6 μM 1.3 and 100%, respectively.

    Journal: Frontiers in Pharmacology

    Article Title: Pioglitazone, a PPAR-γ Activator, Stimulates BKCa but Suppresses IKM in Hippocampal Neurons

    doi: 10.3389/fphar.2018.00977

    Figure Lengend Snippet: Effect of PIO on BK Ca channel activity in mHippoE-14 hippocampal neurons. (A) Original current traces of BK Ca channels obtained in the absence (left) and presence (right) of 10 μM pioglitazone (PIO). The examined cells were bathed in symmetrical K + solution (145 mM). Under inside-out current recordings, the potential was held at +60 mV and bath medium contained 0.1 μM Ca 2+ . The upward deflection represents the opening event of the channel. The lower part indicates the expanded trace recorded from the uppermost part in the control and during exposure to PIO. (B) BK Ca -channel trace obtained after washout of PIO. (C) Concentration-dependent increase in channel open probability (mean ± SEM; n = 9–11 for each point). Channel activity measured at +60 mV during the exposure to 100 μM PIO was taken to be 100%. The values for EC 50 , Hill coefficient and maximal percentage increase of BK Ca channels in the presence of PIO were 7.6 μM 1.3 and 100%, respectively.

    Article Snippet: Pioglitazone (PIO, C19 H2 ON2 O3 S, 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione) was obtained from Takeda Pharmaceutical, Co., Ltd. (Tokyo, Japan), 4-aminopyridine, flupirtine maleate, linopirdine, paxilline, tetraethylammonium chloride and tobutamide were from Sigma-Aldrich (St. Louis, MO, United States), TRAM-39 was from Tocris (Bristol, United Kingdom) and apamin was from Alomone Labs (Jerusalem, Israel).

    Techniques: Activity Assay, Concentration Assay