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  • 93
    ATCC enterobacter cloacae strain atcc 13047
    Enterobacter Cloacae Strain Atcc 13047, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Cell Signaling Technology Inc anti vimentin vim
    Anti Vimentin Vim, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    kma  (ATCC)
    90
    ATCC kma
    Kma, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    CEREP Inc pgn 9856
    Structures of compounds used in these experiments: <t>PGN‐9856,</t> PGN‐9858, PGN‐9862 and PGN‐9863.
    Pgn 9856, supplied by CEREP Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Preiser Scientific 3713 n davidson st 704 376 9856 durham preiser scientific
    Structures of compounds used in these experiments: <t>PGN‐9856,</t> PGN‐9858, PGN‐9862 and PGN‐9863.
    3713 N Davidson St 704 376 9856 Durham Preiser Scientific, supplied by Preiser Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Structures of compounds used in these experiments: PGN‐9856, PGN‐9858, PGN‐9862 and PGN‐9863.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: Structures of compounds used in these experiments: PGN‐9856, PGN‐9858, PGN‐9862 and PGN‐9863.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques:

    Concentration‐dependent displacement of the binding of radiolabelled PGE 2 to human recombinant EP 2 receptors by PGN‐9856. Data are shown as mean ± SEM for n = 3–4 experiments.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: Concentration‐dependent displacement of the binding of radiolabelled PGE 2 to human recombinant EP 2 receptors by PGN‐9856. Data are shown as mean ± SEM for n = 3–4 experiments.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques: Concentration Assay, Binding Assay, Recombinant

    Agonist potency (cAMP response) of PGN‐9856, PGN‐9858, PGN ‐9862, PGN‐9863 and PGE 2 at human recombinant EP 2 receptors. Data are expressed relative to the response to 3 x 10 ‐8 M PGE 2 (set at 100%). Values shown are means ± SEM from 3 individual experiments.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: Agonist potency (cAMP response) of PGN‐9856, PGN‐9858, PGN ‐9862, PGN‐9863 and PGE 2 at human recombinant EP 2 receptors. Data are expressed relative to the response to 3 x 10 ‐8 M PGE 2 (set at 100%). Values shown are means ± SEM from 3 individual experiments.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques: Recombinant

    (A) Effect of PGN‐9856, PGN‐9858, PGN‐9862, PGN‐9863 and the standard EP 2 receptor agonist, butaprost, on TNF‐α release from human LPS‐stimulated peripheral blood monocytes Data are mean ± SEM from 4–5 individual experiments. (B) Activity of PGN‐9856, PGN‐9858, PGN‐9862, PGN‐9863 and the standard EP 2 receptor agonist, butaprost, on IL‐2 release from in human lymphocytes stimulated by anti‐CD3 antibody. Data are mean ± SEM from 3–4 individual experiments.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: (A) Effect of PGN‐9856, PGN‐9858, PGN‐9862, PGN‐9863 and the standard EP 2 receptor agonist, butaprost, on TNF‐α release from human LPS‐stimulated peripheral blood monocytes Data are mean ± SEM from 4–5 individual experiments. (B) Activity of PGN‐9856, PGN‐9858, PGN‐9862, PGN‐9863 and the standard EP 2 receptor agonist, butaprost, on IL‐2 release from in human lymphocytes stimulated by anti‐CD3 antibody. Data are mean ± SEM from 3–4 individual experiments.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques: Activity Assay

    Comparison of the effects of PGN‐9856 and butaprost on inhibition of TNF‐α release in LPS‐stimulated whole blood. Basal release (no LPS) is indicated. Data are given as mean ± SEM from four donors.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: Comparison of the effects of PGN‐9856 and butaprost on inhibition of TNF‐α release in LPS‐stimulated whole blood. Basal release (no LPS) is indicated. Data are given as mean ± SEM from four donors.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques: Inhibition

    (A) Inhibitory effects of PGN‐9856 ( n = 3) and the standard EP 2 receptor agonist butaprost ( n = 7) and DMSO vehicle control ( n = 7) on electrically stimulated human isolated non‐pregnant myometrium. Data shown are mean ± SEM % of the inhibition induced by sodium nitroprusside (SNP) 10 ‐4 M. (B) Original recordings of responses of human myometrial smooth muscle to electrical stimulation at 5 Hz for 10 sec every 100 sec and the inhibition of these responses produced by increasing cumulative concentrations of butaprost (upper trace) and PGN9856 (lower trace). Dots indicate approximately when drug concentrations were administered in 0.5 log unit increments at approximately 10 min intervals, beginning with 10 ‐9 M (‐9). Vertical bar indicates calibration of tension developed (g) for both traces.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: (A) Inhibitory effects of PGN‐9856 ( n = 3) and the standard EP 2 receptor agonist butaprost ( n = 7) and DMSO vehicle control ( n = 7) on electrically stimulated human isolated non‐pregnant myometrium. Data shown are mean ± SEM % of the inhibition induced by sodium nitroprusside (SNP) 10 ‐4 M. (B) Original recordings of responses of human myometrial smooth muscle to electrical stimulation at 5 Hz for 10 sec every 100 sec and the inhibition of these responses produced by increasing cumulative concentrations of butaprost (upper trace) and PGN9856 (lower trace). Dots indicate approximately when drug concentrations were administered in 0.5 log unit increments at approximately 10 min intervals, beginning with 10 ‐9 M (‐9). Vertical bar indicates calibration of tension developed (g) for both traces.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques: Isolation, Inhibition, Produced

    Comparison of the effects of PGN‐9856‐isopropyl ester (PGN‐9856i) and PF‐04217329 on the intraocular pressure of laser‐induced ocular hypertensive monkeys. PGN‐9856i produced a significant reduction in intraocular pressure at the 6, 24, and 48 h post‐dosing time points, compared to the immediate pre‐dosing time point (time 0). PF‐04217329 also produced identically significant reductions in IOP at all time points except at 48 h, when the effect on intraocular pressure had essentially returned to baseline and no statistically significant effect was apparent. Data are means ± SEM, n = 6.

    Journal: British Journal of Pharmacology

    Article Title: The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors

    doi: 10.1111/bph.14525

    Figure Lengend Snippet: Comparison of the effects of PGN‐9856‐isopropyl ester (PGN‐9856i) and PF‐04217329 on the intraocular pressure of laser‐induced ocular hypertensive monkeys. PGN‐9856i produced a significant reduction in intraocular pressure at the 6, 24, and 48 h post‐dosing time points, compared to the immediate pre‐dosing time point (time 0). PF‐04217329 also produced identically significant reductions in IOP at all time points except at 48 h, when the effect on intraocular pressure had essentially returned to baseline and no statistically significant effect was apparent. Data are means ± SEM, n = 6.

    Article Snippet: Broad spectrum profiling of PGN‐9856 was completed (Cerep, Celle‐Lévescault, Poitiers, France) to determine its specificity against a range of 45 receptors (including the Tx TP receptor), 4 ion channels, 2 transporters and 2 kinases.

    Techniques: Produced