8-cineole Search Results


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  • 95
    Millipore 1 8 cineole
    Effects of <t>1,8-cineole</t> on growth of Nicotiana tabacum seedlings. a Effects on hypocotyl length and root length. N. tabacum seedlings were grown in the absence ( control ) or presence ( cineole ) of 440 μM of 1,8-cineole for 10 days, and the hypocotyl length (top) and root length ( bottom ) were measured. Each data point represents the average of 20 individuals that successfully germinated. Vertical bars represent standard errors. b Effects on the cell elongation and cell proliferation in the affected roots. N. tabacum seedlings were grown in the absence ( control ) or presence ( cineole ) of 440 μM 1,8-cineole for 10 days, and the sizes of matured cells ( top ) and mitotic index in the root apical meristem (bottom) were measured. For cell length ( top ), each point represents average value of 60 cells derived from more than 4 individuals. Vertical bars represent standard errors. For mitotic index, each point represents the average value from 8 ( control ) or 7 ( cineole ) individuals. Vertical bars represent standard errors. n.s.; not significant ( P > 0.05), ***; P
    1 8 Cineole, supplied by Millipore, used in various techniques. Bioz Stars score: 95/100, based on 149 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Tokyo Chemical Industry 1 8 cineole
    A comparison of the solid-phase extraction versus the liquid–liquid extraction (ethyl acetate/water). The growth media contained the degraded cellulose as a carbon source. A notable difference is the presence of <t>1,8-cineole</t> in the liquid–liquid extraction. A comparison of the potato dextrose broth gave very similar results and, therefore, is not shown. The identity of 1,8-cineole was verified by comparison to an authentic standard.
    1 8 Cineole, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 92/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Merck & Co 1 8 cineole
    A comparison of the solid-phase extraction versus the liquid–liquid extraction (ethyl acetate/water). The growth media contained the degraded cellulose as a carbon source. A notable difference is the presence of <t>1,8-cineole</t> in the liquid–liquid extraction. A comparison of the potato dextrose broth gave very similar results and, therefore, is not shown. The identity of 1,8-cineole was verified by comparison to an authentic standard.
    1 8 Cineole, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1 8 cineole/product/Merck & Co
    Average 90 stars, based on 2 article reviews
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    88
    Thermo Fisher eucalyptol
    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.
    Eucalyptol, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 88/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    FUJIFILM 1 8 cineole
    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.
    1 8 Cineole, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Greiner Bio 1 8 cineole
    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.
    1 8 Cineole, supplied by Greiner Bio, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Sinopharm 1 8 cineole
    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.
    1 8 Cineole, supplied by Sinopharm, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1 8 cineole/product/Sinopharm
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    90
    Merck KGaA 1 8 cineole
    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.
    1 8 Cineole, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    BioMed Diagnostics Inc major constituent 1 8 cineole eucalyptol biomed pharmacother
    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.
    Major Constituent 1 8 Cineole Eucalyptol Biomed Pharmacother, supplied by BioMed Diagnostics Inc, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Millipore 1 4 cineole
    Percentage of OB mitral–tufted cells and HC CA1 and CA3 pyramidal neurons responding to a panel of five odors. iaa , Isoamyl acetate; cin , <t>1,4-cineole;</t> lim , (+)-limonene; ms , methyl salicylate; xyl , xylene. All odors were delivered manually. Numbers at top of each bin represent the total number of neurons tested. The ratio of responding neurons to total number of tested neurons was converted to percentage to facilitate comparison between sets with different number of neurons tested.
    1 4 Cineole, supplied by Millipore, used in various techniques. Bioz Stars score: 91/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    95
    Millipore essential oil standards 1 8 cineole β pinene
    Percentage of OB mitral–tufted cells and HC CA1 and CA3 pyramidal neurons responding to a panel of five odors. iaa , Isoamyl acetate; cin , <t>1,4-cineole;</t> lim , (+)-limonene; ms , methyl salicylate; xyl , xylene. All odors were delivered manually. Numbers at top of each bin represent the total number of neurons tested. The ratio of responding neurons to total number of tested neurons was converted to percentage to facilitate comparison between sets with different number of neurons tested.
    Essential Oil Standards 1 8 Cineole β Pinene, supplied by Millipore, used in various techniques. Bioz Stars score: 95/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Millipore congo red 1 8 cineol
    Percentage of OB mitral–tufted cells and HC CA1 and CA3 pyramidal neurons responding to a panel of five odors. iaa , Isoamyl acetate; cin , <t>1,4-cineole;</t> lim , (+)-limonene; ms , methyl salicylate; xyl , xylene. All odors were delivered manually. Numbers at top of each bin represent the total number of neurons tested. The ratio of responding neurons to total number of tested neurons was converted to percentage to facilitate comparison between sets with different number of neurons tested.
    Congo Red 1 8 Cineol, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Millipore eucalyptol euc
    Percentage of OB mitral–tufted cells and HC CA1 and CA3 pyramidal neurons responding to a panel of five odors. iaa , Isoamyl acetate; cin , <t>1,4-cineole;</t> lim , (+)-limonene; ms , methyl salicylate; xyl , xylene. All odors were delivered manually. Numbers at top of each bin represent the total number of neurons tested. The ratio of responding neurons to total number of tested neurons was converted to percentage to facilitate comparison between sets with different number of neurons tested.
    Eucalyptol Euc, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    85
    DuPont de Nemours trans 2 hydroxy 1 4 cineole compounds
    Relative activity (percent of control) of AS at different concentrations of cis- and <t>trans-2-hydroxy-1,4-cineole.</t> See “Materials and Methods” for assay conditions. AS activity varied between 1,400 and 1,600 nmol mg −1 h −1 in the control treatments.
    Trans 2 Hydroxy 1 4 Cineole Compounds, supplied by DuPont de Nemours, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Effects of 1,8-cineole on growth of Nicotiana tabacum seedlings. a Effects on hypocotyl length and root length. N. tabacum seedlings were grown in the absence ( control ) or presence ( cineole ) of 440 μM of 1,8-cineole for 10 days, and the hypocotyl length (top) and root length ( bottom ) were measured. Each data point represents the average of 20 individuals that successfully germinated. Vertical bars represent standard errors. b Effects on the cell elongation and cell proliferation in the affected roots. N. tabacum seedlings were grown in the absence ( control ) or presence ( cineole ) of 440 μM 1,8-cineole for 10 days, and the sizes of matured cells ( top ) and mitotic index in the root apical meristem (bottom) were measured. For cell length ( top ), each point represents average value of 60 cells derived from more than 4 individuals. Vertical bars represent standard errors. For mitotic index, each point represents the average value from 8 ( control ) or 7 ( cineole ) individuals. Vertical bars represent standard errors. n.s.; not significant ( P > 0.05), ***; P

    Journal: Journal of Chemical Ecology

    Article Title: 1,8-Cineole Inhibits Both Proliferation and Elongation of BY-2 Cultured Tobacco Cells

    doi: 10.1007/s10886-011-9919-2

    Figure Lengend Snippet: Effects of 1,8-cineole on growth of Nicotiana tabacum seedlings. a Effects on hypocotyl length and root length. N. tabacum seedlings were grown in the absence ( control ) or presence ( cineole ) of 440 μM of 1,8-cineole for 10 days, and the hypocotyl length (top) and root length ( bottom ) were measured. Each data point represents the average of 20 individuals that successfully germinated. Vertical bars represent standard errors. b Effects on the cell elongation and cell proliferation in the affected roots. N. tabacum seedlings were grown in the absence ( control ) or presence ( cineole ) of 440 μM 1,8-cineole for 10 days, and the sizes of matured cells ( top ) and mitotic index in the root apical meristem (bottom) were measured. For cell length ( top ), each point represents average value of 60 cells derived from more than 4 individuals. Vertical bars represent standard errors. For mitotic index, each point represents the average value from 8 ( control ) or 7 ( cineole ) individuals. Vertical bars represent standard errors. n.s.; not significant ( P > 0.05), ***; P

    Article Snippet: 1,8-Cineole, purchased from Aldrich (Milwaukee, WI, USA), was spotted onto a piece of filter paper (3 × 6 cm) hanging from the cap of the container and allowed to volatilize into the airspace within the container.

    Techniques: Derivative Assay

    Effects of 1,8-cineole and its application methods on the proliferation and elongation of BY-2 protoplasts/cells. A Schematic representation of the experimental system. 1,8-Cineole was applied to either filter paper hanging from the cap of the air-tight container (volatilization method) or the culture medium in the flask (direct-addition method). The calculated final concentrations of 1,8-cineole in the airspace (gas-phase) were 0 to 3,000 μM. In direct-addition method, the initial concentrations of 1,8-cineole in the culture medium (liquid-phase) were 50 times higher than the calculated final concentrations in the airspace (gas-phase). ( B ) Effects of 1,8-cineole on the proliferation of BY-2 protoplasts grown in 2,4-D medium. Various doses of 1,8-cineole were applied through either the volatilization method ( left ) or the direct-addition method ( right ), and the mitotic index was examined on d 2. Each data point was determined by counting more than 1,000 cells/protoplasts. C Effects of 1,8-cineole on the elongation of BY-2 protoplasts grown in BA-NAA medium. Various doses of 1,8-cineole were applied through either the volatilization method ( left ) or the direct-addition method ( right ), and cell length was examined on day 0 and day 7. Each point represents the average value from 200–600 cells/protoplasts. Vertical bars represent standard errors. In B and C , IC 50 values estimated from the data are shown in the respective graphs

    Journal: Journal of Chemical Ecology

    Article Title: 1,8-Cineole Inhibits Both Proliferation and Elongation of BY-2 Cultured Tobacco Cells

    doi: 10.1007/s10886-011-9919-2

    Figure Lengend Snippet: Effects of 1,8-cineole and its application methods on the proliferation and elongation of BY-2 protoplasts/cells. A Schematic representation of the experimental system. 1,8-Cineole was applied to either filter paper hanging from the cap of the air-tight container (volatilization method) or the culture medium in the flask (direct-addition method). The calculated final concentrations of 1,8-cineole in the airspace (gas-phase) were 0 to 3,000 μM. In direct-addition method, the initial concentrations of 1,8-cineole in the culture medium (liquid-phase) were 50 times higher than the calculated final concentrations in the airspace (gas-phase). ( B ) Effects of 1,8-cineole on the proliferation of BY-2 protoplasts grown in 2,4-D medium. Various doses of 1,8-cineole were applied through either the volatilization method ( left ) or the direct-addition method ( right ), and the mitotic index was examined on d 2. Each data point was determined by counting more than 1,000 cells/protoplasts. C Effects of 1,8-cineole on the elongation of BY-2 protoplasts grown in BA-NAA medium. Various doses of 1,8-cineole were applied through either the volatilization method ( left ) or the direct-addition method ( right ), and cell length was examined on day 0 and day 7. Each point represents the average value from 200–600 cells/protoplasts. Vertical bars represent standard errors. In B and C , IC 50 values estimated from the data are shown in the respective graphs

    Article Snippet: 1,8-Cineole, purchased from Aldrich (Milwaukee, WI, USA), was spotted onto a piece of filter paper (3 × 6 cm) hanging from the cap of the container and allowed to volatilize into the airspace within the container.

    Techniques:

    Effects of various concentrations of 1,8-cineole on Nicotiana tabacum seed germination and seedling growth. Germination rate ( top ), hypocotyl length ( middle ), and root length ( bottom ) were measured on day 10. Each data point for germination rate was calculated from the results of all 50 individuals contained in a single container, while each for hypocotyl and root length represents the average value from 30 individuals that successfully germinated. Vertical bars represent standard errors. IC 50 values calculated from the data are shown in respective graphs

    Journal: Journal of Chemical Ecology

    Article Title: 1,8-Cineole Inhibits Both Proliferation and Elongation of BY-2 Cultured Tobacco Cells

    doi: 10.1007/s10886-011-9919-2

    Figure Lengend Snippet: Effects of various concentrations of 1,8-cineole on Nicotiana tabacum seed germination and seedling growth. Germination rate ( top ), hypocotyl length ( middle ), and root length ( bottom ) were measured on day 10. Each data point for germination rate was calculated from the results of all 50 individuals contained in a single container, while each for hypocotyl and root length represents the average value from 30 individuals that successfully germinated. Vertical bars represent standard errors. IC 50 values calculated from the data are shown in respective graphs

    Article Snippet: 1,8-Cineole, purchased from Aldrich (Milwaukee, WI, USA), was spotted onto a piece of filter paper (3 × 6 cm) hanging from the cap of the container and allowed to volatilize into the airspace within the container.

    Techniques:

    Effects of 1,8-cineole on the proliferation and elongation of BY-2 cells. A The effects of a range of doses of 1,8-cineole on the proliferation of BY-2 cells cultured in D-medium are shown. The mitotic index was examined on d 2. The average values from three independent experiments are shown. Vertical bars represent standard errors. B The effects of a range of doses of 1,8-cineole on elongation ( top ) and starch accumulation ( bottom ) in BY-2 cells cultured in B-medium. Cell length and starch content were examined on d 2. The average values from three independent experiments are shown. Vertical bars represent standard errors. In A and B , 1,8-cineole was applied through the direct-addition method only. The estimated final concentrations of 1,8-cineole in the airspace (gas phase) were 0 to 240 μM, while the initial concentrations in the culture medium (liquid phase) immediately after application were 25 times higher. IC 50 values estimated from the data are shown in respective graphs

    Journal: Journal of Chemical Ecology

    Article Title: 1,8-Cineole Inhibits Both Proliferation and Elongation of BY-2 Cultured Tobacco Cells

    doi: 10.1007/s10886-011-9919-2

    Figure Lengend Snippet: Effects of 1,8-cineole on the proliferation and elongation of BY-2 cells. A The effects of a range of doses of 1,8-cineole on the proliferation of BY-2 cells cultured in D-medium are shown. The mitotic index was examined on d 2. The average values from three independent experiments are shown. Vertical bars represent standard errors. B The effects of a range of doses of 1,8-cineole on elongation ( top ) and starch accumulation ( bottom ) in BY-2 cells cultured in B-medium. Cell length and starch content were examined on d 2. The average values from three independent experiments are shown. Vertical bars represent standard errors. In A and B , 1,8-cineole was applied through the direct-addition method only. The estimated final concentrations of 1,8-cineole in the airspace (gas phase) were 0 to 240 μM, while the initial concentrations in the culture medium (liquid phase) immediately after application were 25 times higher. IC 50 values estimated from the data are shown in respective graphs

    Article Snippet: 1,8-Cineole, purchased from Aldrich (Milwaukee, WI, USA), was spotted onto a piece of filter paper (3 × 6 cm) hanging from the cap of the container and allowed to volatilize into the airspace within the container.

    Techniques: Cell Culture

    Total ion chromatogram of rose hydrosol. 1 : 1,8-cineole (internal standard), 2 : linalool, 3 : 4-terpineol, 4 : alpha terpineol, 5 : citronellol, 6 : nerol, 7 : geraniol, 8 : 2-phenlyethanol, 9 : methyl eugenol, 10 : eugenol.

    Journal: Molecules

    Article Title: Effects of Orally Consumed Rosa damascena Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats

    doi: 10.3390/molecules24224069

    Figure Lengend Snippet: Total ion chromatogram of rose hydrosol. 1 : 1,8-cineole (internal standard), 2 : linalool, 3 : 4-terpineol, 4 : alpha terpineol, 5 : citronellol, 6 : nerol, 7 : geraniol, 8 : 2-phenlyethanol, 9 : methyl eugenol, 10 : eugenol.

    Article Snippet: Citronellol and 1,8-Cineole reference substances were purchased from Sigma–Aldrich (St. Louis, MO, USA).

    Techniques:

    Effect of 1,8-cineole on UVB-induced skin tumorigenesis in SKH-1 hairless mouse skin (a) The external appearance of mice at 22 weeks after UVB-treatment. The mice in control group (n = 5) were subjected to the topical treatment of 200 μL acetone on dorsal skin without UVB irradiation (0.20 J/cm 2 ) at 3 days/week for 22 weeks. The mice in UVB-irradiated groups (n = 5 per each group) were treated with 200 μL acetone or the indicated amount of 1,8-cineole (40 nmol or 200 nmol) in 200 μL acetone topically on the dorsal skin for 1 hour before UVB irradiation (0.20 J/cm 2 ) for 3 days/week for 22 weeks. (b) 1,8-cineole suppresses UVB-induced tumor incidence in SKH-1 hairless mice. The incidence of skin tumors was recorded weekly. A tumor was defined as an outgrowth > 1 mm in diameter that persisted for 2 weeks or longer. Tumor incidence and multiplicity were recorded each week until the end of the experiment at 22 weeks. Asterisk symbols ( * and ** ) indicates a significant difference (p

    Journal: Oncotarget

    Article Title: 1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor

    doi: 10.18632/oncotarget.22519

    Figure Lengend Snippet: Effect of 1,8-cineole on UVB-induced skin tumorigenesis in SKH-1 hairless mouse skin (a) The external appearance of mice at 22 weeks after UVB-treatment. The mice in control group (n = 5) were subjected to the topical treatment of 200 μL acetone on dorsal skin without UVB irradiation (0.20 J/cm 2 ) at 3 days/week for 22 weeks. The mice in UVB-irradiated groups (n = 5 per each group) were treated with 200 μL acetone or the indicated amount of 1,8-cineole (40 nmol or 200 nmol) in 200 μL acetone topically on the dorsal skin for 1 hour before UVB irradiation (0.20 J/cm 2 ) for 3 days/week for 22 weeks. (b) 1,8-cineole suppresses UVB-induced tumor incidence in SKH-1 hairless mice. The incidence of skin tumors was recorded weekly. A tumor was defined as an outgrowth > 1 mm in diameter that persisted for 2 weeks or longer. Tumor incidence and multiplicity were recorded each week until the end of the experiment at 22 weeks. Asterisk symbols ( * and ** ) indicates a significant difference (p

    Article Snippet: Reagents and antibodies 1,8-cineole (99%) and N -Acetyl-L-cysteine (NAC, 99%) were purchased from Sigma Aldrich (St. Louis, MO, USA).

    Techniques: Mouse Assay, Irradiation

    Effect of 1,8-cineole on UVB-induced phosphorylation of MAPKs in HaCaT cells (a) and (b) 1,8-cineole inhibits UVB-induced phosphorylation of ERK1/2, MEK1/2, BRAF, and CRAF, (c) but not MKK4/7, JNK1/2, MKK3/6, and p38 in HaCaT cells. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then harvested after 15 min. Phosphorylation levels of proteins were detected by Western blotting.

    Journal: Oncotarget

    Article Title: 1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor

    doi: 10.18632/oncotarget.22519

    Figure Lengend Snippet: Effect of 1,8-cineole on UVB-induced phosphorylation of MAPKs in HaCaT cells (a) and (b) 1,8-cineole inhibits UVB-induced phosphorylation of ERK1/2, MEK1/2, BRAF, and CRAF, (c) but not MKK4/7, JNK1/2, MKK3/6, and p38 in HaCaT cells. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then harvested after 15 min. Phosphorylation levels of proteins were detected by Western blotting.

    Article Snippet: Reagents and antibodies 1,8-cineole (99%) and N -Acetyl-L-cysteine (NAC, 99%) were purchased from Sigma Aldrich (St. Louis, MO, USA).

    Techniques: Irradiation, Western Blot

    Effect of 1,8-cineole on UVB induction of the AhR/c-Src/EGFR signaling pathway and direct binding with AhR (a) 1,8-cineole inhibits UVB-induced phosphorylation of c-Src Tyr-416 and EGFR Tyr-845 residues in HaCaT cells. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then harvested after 15 min. Phosphorylation levels of proteins were detected by Western blotting. (b) and (c) 1,8-cineole suppresses UVB-induced AhR nuclear translocation and dissociation from c-Src in HaCaT cells. Cells were pretreated with 1,8-cineole for 1 hours, before irradiation with UVB for 30 min. (b) AhR (green) and p-c-Src (Tyr 416) (red) were detected by fluorescence microscopy. Nuclei were counterstained with DAPI (blue). White arrows indicate inhibition of AhR nuclear translocation and c-Src phosphorylation by 1,8-cineole treatment in HaCaT cells. Scale bar, 50 μm. (c) Co-immunoprecipitation assay was performed asdescribedin the ‘Materials and Methods’ and levels of AhR and c-Src were detected by Western blotting. (d) 1,8-cineole inhibits UVB-induced CYP1A1 mRNA upregulation in HaCaT cells. CYP1A1 mRNA levels were measured by qRT-PCR. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, and irradiated with UVB before total RNA was extracted after 4 hours. (e) 1,8-cineole directly binds to AhR but not (f) EGFR or (g) c-Src in HaCaT cells. For the DARTS assay, cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour and lysed. The lysates were digested with pronase (at the indicated pronase to protein ratio) and subjected to Western blotting.

    Journal: Oncotarget

    Article Title: 1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor

    doi: 10.18632/oncotarget.22519

    Figure Lengend Snippet: Effect of 1,8-cineole on UVB induction of the AhR/c-Src/EGFR signaling pathway and direct binding with AhR (a) 1,8-cineole inhibits UVB-induced phosphorylation of c-Src Tyr-416 and EGFR Tyr-845 residues in HaCaT cells. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then harvested after 15 min. Phosphorylation levels of proteins were detected by Western blotting. (b) and (c) 1,8-cineole suppresses UVB-induced AhR nuclear translocation and dissociation from c-Src in HaCaT cells. Cells were pretreated with 1,8-cineole for 1 hours, before irradiation with UVB for 30 min. (b) AhR (green) and p-c-Src (Tyr 416) (red) were detected by fluorescence microscopy. Nuclei were counterstained with DAPI (blue). White arrows indicate inhibition of AhR nuclear translocation and c-Src phosphorylation by 1,8-cineole treatment in HaCaT cells. Scale bar, 50 μm. (c) Co-immunoprecipitation assay was performed asdescribedin the ‘Materials and Methods’ and levels of AhR and c-Src were detected by Western blotting. (d) 1,8-cineole inhibits UVB-induced CYP1A1 mRNA upregulation in HaCaT cells. CYP1A1 mRNA levels were measured by qRT-PCR. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, and irradiated with UVB before total RNA was extracted after 4 hours. (e) 1,8-cineole directly binds to AhR but not (f) EGFR or (g) c-Src in HaCaT cells. For the DARTS assay, cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour and lysed. The lysates were digested with pronase (at the indicated pronase to protein ratio) and subjected to Western blotting.

    Article Snippet: Reagents and antibodies 1,8-cineole (99%) and N -Acetyl-L-cysteine (NAC, 99%) were purchased from Sigma Aldrich (St. Louis, MO, USA).

    Techniques: Binding Assay, Irradiation, Western Blot, Translocation Assay, Fluorescence, Microscopy, Inhibition, Co-Immunoprecipitation Assay, Quantitative RT-PCR

    Effect of 1,8-cineole on UVB-induced COX-2 expression and epidermal hyperplasia in SKH-1 hairless mouse skin (a) and (b) 1,8-cineole inhibits UVB-induced COX-2 expression in SKH-1 mouse skin. Expression levels of proteins were detected by Western blotting. Each band was densitometrically quantified by image analysis. The band density of COX-2 was normalized to β-actin followed by statistical analysis. Quantification data are represented as means ± SD (n = 3). Immunohistochemical analysis shows representative photographs of overall staining patterns from each group. The expression level of COX-2 proteins was stained as brown and the nucleus was counterstained as blue. Scale bar, 20 μm. (c) 1,8-cineole inhibis UVB-induced epidermal hyperplasia in SKH-1 mouse skin. Hematoxylin- and eosin-staining shows representative photographs of overall staining patterns from each group. Scale bar, 20 μm. Bars graph represent epidermal thickness (μm) of the indicated groups. Hash symbol ( # ) indicates a significant difference between the control and the UVB-treated group (p

    Journal: Oncotarget

    Article Title: 1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor

    doi: 10.18632/oncotarget.22519

    Figure Lengend Snippet: Effect of 1,8-cineole on UVB-induced COX-2 expression and epidermal hyperplasia in SKH-1 hairless mouse skin (a) and (b) 1,8-cineole inhibits UVB-induced COX-2 expression in SKH-1 mouse skin. Expression levels of proteins were detected by Western blotting. Each band was densitometrically quantified by image analysis. The band density of COX-2 was normalized to β-actin followed by statistical analysis. Quantification data are represented as means ± SD (n = 3). Immunohistochemical analysis shows representative photographs of overall staining patterns from each group. The expression level of COX-2 proteins was stained as brown and the nucleus was counterstained as blue. Scale bar, 20 μm. (c) 1,8-cineole inhibis UVB-induced epidermal hyperplasia in SKH-1 mouse skin. Hematoxylin- and eosin-staining shows representative photographs of overall staining patterns from each group. Scale bar, 20 μm. Bars graph represent epidermal thickness (μm) of the indicated groups. Hash symbol ( # ) indicates a significant difference between the control and the UVB-treated group (p

    Article Snippet: Reagents and antibodies 1,8-cineole (99%) and N -Acetyl-L-cysteine (NAC, 99%) were purchased from Sigma Aldrich (St. Louis, MO, USA).

    Techniques: Expressing, Western Blot, Immunohistochemistry, Staining

    Effect of 1,8-cineole on UVB-induced COX-2 protein, mRNA expression, and PGE2 generation in HaCaT cells (a) Chemical structure of 1,8-cineole. (b) 1,8-cineole inhibits UVB-induced COX-2 protein expression in HaCaT cells. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then harvested after 18 hours. Expression levels of COX-2 and β-actin were determined by Western blotting. Data are representative of three independent experiments that gave similar results. (c) 1,8-cineole inhibits UVB-induced COX-2 mRNA expression in HaCaT cells. COX-2 mRNA levels were measured by qRT-PCR. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then total RNA was extracted after 4 hours. Data are represented as the mean ± SD of three independent experiments. (d) 1,8-cineole inhibits UVB-induced PGE 2 generation in HaCaT cells. The quantity of PGE 2 in the culture medium was measured by ELISA. Data are represented as the mean ± SD of three independent experiments. Hash symbol ( # ) indicates a significant difference between the control and the UVB-treated group; asterisk symbols ( * and *** ) indicate significant differences (p

    Journal: Oncotarget

    Article Title: 1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor

    doi: 10.18632/oncotarget.22519

    Figure Lengend Snippet: Effect of 1,8-cineole on UVB-induced COX-2 protein, mRNA expression, and PGE2 generation in HaCaT cells (a) Chemical structure of 1,8-cineole. (b) 1,8-cineole inhibits UVB-induced COX-2 protein expression in HaCaT cells. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then harvested after 18 hours. Expression levels of COX-2 and β-actin were determined by Western blotting. Data are representative of three independent experiments that gave similar results. (c) 1,8-cineole inhibits UVB-induced COX-2 mRNA expression in HaCaT cells. COX-2 mRNA levels were measured by qRT-PCR. Cells were pre-treated with 1,8-cineole at the indicated concentrations for 1 hour, irradiated with UVB, and then total RNA was extracted after 4 hours. Data are represented as the mean ± SD of three independent experiments. (d) 1,8-cineole inhibits UVB-induced PGE 2 generation in HaCaT cells. The quantity of PGE 2 in the culture medium was measured by ELISA. Data are represented as the mean ± SD of three independent experiments. Hash symbol ( # ) indicates a significant difference between the control and the UVB-treated group; asterisk symbols ( * and *** ) indicate significant differences (p

    Article Snippet: Reagents and antibodies 1,8-cineole (99%) and N -Acetyl-L-cysteine (NAC, 99%) were purchased from Sigma Aldrich (St. Louis, MO, USA).

    Techniques: Expressing, Irradiation, Western Blot, Quantitative RT-PCR, Enzyme-linked Immunosorbent Assay

    ( a ) Macroscopic and microscopic views of liver of 20-week-old Pten KO mice without any treatment ( upper ; control) and 1,8-cineole treatment for eight weeks ( lower ; 1,8-cineole). The liver in the control group (first line upper) was enlarged, where as the liver in the 1,8-cineole group was smaller than that in the control group. HE stained livers of the control group (100× second line upper) and the 1,8-cineole group (100× second line lower) indicate vacuoles in hepatocytes were decreased in the 1,8-cineole group. Lipid accumulation was confirmed by Oil red O staining (100× control; third upper, 1,8-cineole group; third lower). Sirius red staining of the liver (400× control; fourth upper, 1,8-cineole; fourth lower). In the 1,8-cineole group, fibrotic area is narrower than in the control group; ( b ) Oil red O positive area (%) is compared between the two groups. *, p

    Journal: International Journal of Molecular Sciences

    Article Title: 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation

    doi: 10.3390/ijms160612051

    Figure Lengend Snippet: ( a ) Macroscopic and microscopic views of liver of 20-week-old Pten KO mice without any treatment ( upper ; control) and 1,8-cineole treatment for eight weeks ( lower ; 1,8-cineole). The liver in the control group (first line upper) was enlarged, where as the liver in the 1,8-cineole group was smaller than that in the control group. HE stained livers of the control group (100× second line upper) and the 1,8-cineole group (100× second line lower) indicate vacuoles in hepatocytes were decreased in the 1,8-cineole group. Lipid accumulation was confirmed by Oil red O staining (100× control; third upper, 1,8-cineole group; third lower). Sirius red staining of the liver (400× control; fourth upper, 1,8-cineole; fourth lower). In the 1,8-cineole group, fibrotic area is narrower than in the control group; ( b ) Oil red O positive area (%) is compared between the two groups. *, p

    Article Snippet: Western Blot Analysis For western blot analysis, total protein extracts of control and 1,8-cineole group mice livers were obtained, then separated by 10% SDS-PAGE and transferred to nitrocellulose membrane (Millipore, Bedford, MA, USA).

    Techniques: Mouse Assay, Staining

    ( a ) Western blot of fatty acid synthase (FASN), phospho Akt (P-Akt), total Akt (T-Akt), phospho mTOR (P-mTOR), total mTOR (mTOR), Phospho-protein phosphatase type 2A (P-PP2A), total PP2A (PP2A), phospho-insulin receptor (P-insulin receptor), total insulin receptor (insulin receptor) and Glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In the 1,8-cineole group, FASN, P-Akt, P-mTOR, and P-PP2A were decreased. P-insulin receptor was increased in the 1,8-cineole group. Densitometry of FASN/GAPDH ( b ), phospho/total Akt ( c ), phospho/total mTOR ( d ), phospho/total PP2A ( e ), and phospho/total insulin receptor ( f ) in the two groups ( n = 3). In the 1,8-cineole group, Akt and PP2A were significantly dephosphorylated, and the insulin receptor was significantly activated. * p

    Journal: International Journal of Molecular Sciences

    Article Title: 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation

    doi: 10.3390/ijms160612051

    Figure Lengend Snippet: ( a ) Western blot of fatty acid synthase (FASN), phospho Akt (P-Akt), total Akt (T-Akt), phospho mTOR (P-mTOR), total mTOR (mTOR), Phospho-protein phosphatase type 2A (P-PP2A), total PP2A (PP2A), phospho-insulin receptor (P-insulin receptor), total insulin receptor (insulin receptor) and Glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In the 1,8-cineole group, FASN, P-Akt, P-mTOR, and P-PP2A were decreased. P-insulin receptor was increased in the 1,8-cineole group. Densitometry of FASN/GAPDH ( b ), phospho/total Akt ( c ), phospho/total mTOR ( d ), phospho/total PP2A ( e ), and phospho/total insulin receptor ( f ) in the two groups ( n = 3). In the 1,8-cineole group, Akt and PP2A were significantly dephosphorylated, and the insulin receptor was significantly activated. * p

    Article Snippet: Western Blot Analysis For western blot analysis, total protein extracts of control and 1,8-cineole group mice livers were obtained, then separated by 10% SDS-PAGE and transferred to nitrocellulose membrane (Millipore, Bedford, MA, USA).

    Techniques: Western Blot

    Chemical structure of MMF (a), MPA (b), EUL (c), and NMP (d).

    Journal: Scientifica

    Article Title: Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone

    doi: 10.1155/2016/9672718

    Figure Lengend Snippet: Chemical structure of MMF (a), MPA (b), EUL (c), and NMP (d).

    Article Snippet: EUL (1,8 cineole), NMP, and triethylamine were purchased from Sigma-Aldrich (Denmark).

    Techniques:

    Skin permeation profiles of MMF (a) and MPA (b) at various concentration ratios of mixed enhancers between EUL and NMP incorporated to 300 μ g/mL of MMF preparation.

    Journal: Scientifica

    Article Title: Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone

    doi: 10.1155/2016/9672718

    Figure Lengend Snippet: Skin permeation profiles of MMF (a) and MPA (b) at various concentration ratios of mixed enhancers between EUL and NMP incorporated to 300 μ g/mL of MMF preparation.

    Article Snippet: EUL (1,8 cineole), NMP, and triethylamine were purchased from Sigma-Aldrich (Denmark).

    Techniques: Concentration Assay

    A comparison of the solid-phase extraction versus the liquid–liquid extraction (ethyl acetate/water). The growth media contained the degraded cellulose as a carbon source. A notable difference is the presence of 1,8-cineole in the liquid–liquid extraction. A comparison of the potato dextrose broth gave very similar results and, therefore, is not shown. The identity of 1,8-cineole was verified by comparison to an authentic standard.

    Journal: Journal of Fungi

    Article Title: A Solvent-Free Approach for Converting Cellulose Waste into Volatile Organic Compounds with Endophytic Fungi

    doi: 10.3390/jof4030102

    Figure Lengend Snippet: A comparison of the solid-phase extraction versus the liquid–liquid extraction (ethyl acetate/water). The growth media contained the degraded cellulose as a carbon source. A notable difference is the presence of 1,8-cineole in the liquid–liquid extraction. A comparison of the potato dextrose broth gave very similar results and, therefore, is not shown. The identity of 1,8-cineole was verified by comparison to an authentic standard.

    Article Snippet: A sample of 1,8-cineole was obtained from TCI chemicals (Portland, OR, USA).

    Techniques:

    Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.

    Journal: PLoS ONE

    Article Title: Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole: Role of pattern recognition receptors TREM-1 and NLRP3, the MAP kinase regulator MKP-1, and NFκB

    doi: 10.1371/journal.pone.0188232

    Figure Lengend Snippet: Schematic representation of immune-modulatory mode of action of eucalyptus oil and its constituent 1, 8-cineole on different targets of LPS/infection-induced pathways in alveolar macrophage. Abbreviations : EO, Eucalyptus oil; Cin, 1,8-Cineole; LPS, Lipopolysaccharide; TLR, Toll-like receptor; LBP, LPS-binding protein; CD14, Cluster of differentiation 14; TREM-1, Triggering receptor expressed on myeloid cells 1; IRAKs, IL-1 Receptor-Associated Kinases; TRAF6, TNF receptor-associated factor 6; MAPKs, Mitogen-activated protein kinases; ERK, Extracellular signal–regulated kinases; JNK: c-Jun N-terminal kinases; MKP-1, MAP kinase phosphatase-1; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3, Nod-like receptor family pyrin domain containing 3; NO, Nitric oxide: TF, Transcription factor.

    Article Snippet: Purified EO constituent 1,8-cineole (eucalyptol) was obtained commercially (Alfa Aesar, Reston, VA, USA); the working stock (2% vol/vol or 0.119 M) was prepared in 10% methanol (MeOH).

    Techniques: Infection, Binding Assay

    Percentage of OB mitral–tufted cells and HC CA1 and CA3 pyramidal neurons responding to a panel of five odors. iaa , Isoamyl acetate; cin , 1,4-cineole; lim , (+)-limonene; ms , methyl salicylate; xyl , xylene. All odors were delivered manually. Numbers at top of each bin represent the total number of neurons tested. The ratio of responding neurons to total number of tested neurons was converted to percentage to facilitate comparison between sets with different number of neurons tested.

    Journal: The Journal of Neuroscience

    Article Title: Representation of Odor Habituation and Timing in the Hippocampus

    doi: 10.1523/JNEUROSCI.23-05-01903.2003

    Figure Lengend Snippet: Percentage of OB mitral–tufted cells and HC CA1 and CA3 pyramidal neurons responding to a panel of five odors. iaa , Isoamyl acetate; cin , 1,4-cineole; lim , (+)-limonene; ms , methyl salicylate; xyl , xylene. All odors were delivered manually. Numbers at top of each bin represent the total number of neurons tested. The ratio of responding neurons to total number of tested neurons was converted to percentage to facilitate comparison between sets with different number of neurons tested.

    Article Snippet: The following odors were used for the experiments: isoamyl acetate (Ranbaxy Fine Chemicals, New Delhi, India), 1,4-cineole, (+)-limonene (both from Sigma, St. Louis, MO), methyl salicylate (Polykem, Salem, India), and xylene (Qualigens, Mumbai, India).

    Techniques: Mass Spectrometry

    Relative activity (percent of control) of AS at different concentrations of cis- and trans-2-hydroxy-1,4-cineole. See “Materials and Methods” for assay conditions. AS activity varied between 1,400 and 1,600 nmol mg −1 h −1 in the control treatments.

    Journal: Plant Physiology

    Article Title: Inhibition of Plant Asparagine Synthetase by Monoterpene Cineoles 1

    doi:

    Figure Lengend Snippet: Relative activity (percent of control) of AS at different concentrations of cis- and trans-2-hydroxy-1,4-cineole. See “Materials and Methods” for assay conditions. AS activity varied between 1,400 and 1,600 nmol mg −1 h −1 in the control treatments.

    Article Snippet: The cis- and trans-2-hydroxy-1,4-cineole compounds were gifts from DuPont Agricultural Products.

    Techniques: Activity Assay