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Image Search Results

Journal: Oncotarget
Article Title: Combined HAT/EZH2 modulation leads to cancer-selective cell death
doi: 10.18632/oncotarget.25428
Figure Lengend Snippet: ( A) MC2884 inhibits EZH2 activity in vitro . ( B) MC2884 inhibits HAT activity in total cell extracts. ( C) MC2884 inhibits the indicated HATs in vitro . ( D) Western blot analyses for H3K27me3, H3K27ac, EZH2 and H3K9/14ac indicate that MC2884 is able to modulate their expression in NB4 APL cells. * indicates that the MC2884 has been added a second time after 10 h. Histone H1 and tubulin represent loading controls. ( E) Simultaneous but not single inhibition of EZH2 and p300 displays anticancer effect in NB4 APL cells, as shown by FACS analysis (top). Western blot analyses for H3K9/14ac, H3K27me3 and EZH2 showing the efficacy of the indicated treatments (bottom). MC2884 was used at indicated time and concentrations. Graph showed the mean of three independent experiments with error bars indicating standard deviation.
Article Snippet: The following plasmids were used: 1245
Techniques: Activity Assay, In Vitro, Western Blot, Expressing, Inhibition, Standard Deviation

Journal: Oncotarget
Article Title: Combined HAT/EZH2 modulation leads to cancer-selective cell death
doi: 10.18632/oncotarget.25428
Figure Lengend Snippet:
Article Snippet: The following plasmids were used: 1245
Techniques: