5a1 Search Results


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  • 90
    Thermo Fisher abca1 probe
    SUS analysis of TG and <t>ABCA1</t> OPLS-DA models identifies potential directions for development of ligands with improved therapeutic profiles. SUS plot ( a ) and the corresponding p(corr) values mapped on the crystal structures of LXRα (2ACL.pdb) and LXRβ (1PQC.pdb) ( b ) according to shared color code. Dark green: p(corr) ABCA1 > 0.5, p(corr) TG
    Abca1 Probe, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 90 stars, based on 7 article reviews
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    abca1 probe - by Bioz Stars, 2020-02
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    79
    Cell Signaling Technology Inc 5a1
    SUS analysis of TG and <t>ABCA1</t> OPLS-DA models identifies potential directions for development of ligands with improved therapeutic profiles. SUS plot ( a ) and the corresponding p(corr) values mapped on the crystal structures of LXRα (2ACL.pdb) and LXRβ (1PQC.pdb) ( b ) according to shared color code. Dark green: p(corr) ABCA1 > 0.5, p(corr) TG
    5a1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 79/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/5a1/product/Cell Signaling Technology Inc
    Average 79 stars, based on 10 article reviews
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    5a1 - by Bioz Stars, 2020-02
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    90
    Novus Biologicals anti abca1 antibody
    Induction of macrophages genes by ATRA. (A) Mouse peritoneal macrophages in DMEM containing 10% LPDS were treated for 24 h with various concentrations of ATRA (0.1 to 5 μM) or vehicle (DMSO). (B) Human monocyte-derived macrophages were treated for 24 h with various concentrations of ATRA (0.5 to 5 μM) or vehicle (DMSO). The expression of <t>ABCA1,</t> ABCG1, SREBP-1c, apoE, and LXRα mRNA were measured by quantitative real-time PCR assays (TaqMan) and standardized against β-actin mRNA levels. ✽, P
    Anti Abca1 Antibody, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti abca1 antibody/product/Novus Biologicals
    Average 90 stars, based on 1 article reviews
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    anti abca1 antibody - by Bioz Stars, 2020-02
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    78
    The Jackson Laboratory receptor 5a1 nr5a cre mice
    Induction of macrophages genes by ATRA. (A) Mouse peritoneal macrophages in DMEM containing 10% LPDS were treated for 24 h with various concentrations of ATRA (0.1 to 5 μM) or vehicle (DMSO). (B) Human monocyte-derived macrophages were treated for 24 h with various concentrations of ATRA (0.5 to 5 μM) or vehicle (DMSO). The expression of <t>ABCA1,</t> ABCG1, SREBP-1c, apoE, and LXRα mRNA were measured by quantitative real-time PCR assays (TaqMan) and standardized against β-actin mRNA levels. ✽, P
    Receptor 5a1 Nr5a Cre Mice, supplied by The Jackson Laboratory, used in various techniques. Bioz Stars score: 78/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/receptor 5a1 nr5a cre mice/product/The Jackson Laboratory
    Average 78 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
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    79
    Bio X Cell αcsf1 5a1 antibodies
    Induction of macrophages genes by ATRA. (A) Mouse peritoneal macrophages in DMEM containing 10% LPDS were treated for 24 h with various concentrations of ATRA (0.1 to 5 μM) or vehicle (DMSO). (B) Human monocyte-derived macrophages were treated for 24 h with various concentrations of ATRA (0.5 to 5 μM) or vehicle (DMSO). The expression of <t>ABCA1,</t> ABCG1, SREBP-1c, apoE, and LXRα mRNA were measured by quantitative real-time PCR assays (TaqMan) and standardized against β-actin mRNA levels. ✽, P
    αcsf1 5a1 Antibodies, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 79/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/αcsf1 5a1 antibodies/product/Bio X Cell
    Average 79 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    αcsf1 5a1 antibodies - by Bioz Stars, 2020-02
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    83
    Abnova mouse anti aladin 5a1
    Induction of macrophages genes by ATRA. (A) Mouse peritoneal macrophages in DMEM containing 10% LPDS were treated for 24 h with various concentrations of ATRA (0.1 to 5 μM) or vehicle (DMSO). (B) Human monocyte-derived macrophages were treated for 24 h with various concentrations of ATRA (0.5 to 5 μM) or vehicle (DMSO). The expression of <t>ABCA1,</t> ABCG1, SREBP-1c, apoE, and LXRα mRNA were measured by quantitative real-time PCR assays (TaqMan) and standardized against β-actin mRNA levels. ✽, P
    Mouse Anti Aladin 5a1, supplied by Abnova, used in various techniques. Bioz Stars score: 83/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mouse anti aladin 5a1/product/Abnova
    Average 83 stars, based on 7 article reviews
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    mouse anti aladin 5a1 - by Bioz Stars, 2020-02
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    80
    Becton Dickinson mouse anti eif 5a1
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Mouse Anti Eif 5a1, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 80/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mouse anti eif 5a1/product/Becton Dickinson
    Average 80 stars, based on 6 article reviews
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    77
    Syntaxin syntaxin 5a1 260 inhibits exocytosis
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Syntaxin 5a1 260 Inhibits Exocytosis, supplied by Syntaxin, used in various techniques. Bioz Stars score: 77/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/syntaxin 5a1 260 inhibits exocytosis/product/Syntaxin
    Average 77 stars, based on 3 article reviews
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    78
    Bio X Cell anti csf1 5a1 monoclonal antibody
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Anti Csf1 5a1 Monoclonal Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 78/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti csf1 5a1 monoclonal antibody/product/Bio X Cell
    Average 78 stars, based on 3 article reviews
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    79
    Cell Signaling Technology Inc cleaved caspase 3 5a1
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Cleaved Caspase 3 5a1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 79/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 79 stars, based on 5 article reviews
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    79
    Cell Signaling Technology Inc cleaved caspase 3 asp175 rabbit monoclonal clone 5a1
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Cleaved Caspase 3 Asp175 Rabbit Monoclonal Clone 5a1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 79/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cleaved caspase 3 asp175 rabbit monoclonal clone 5a1/product/Cell Signaling Technology Inc
    Average 79 stars, based on 4 article reviews
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    90
    Cell Signaling Technology Inc caspase 3 asp175 5a1
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Caspase 3 Asp175 5a1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/caspase 3 asp175 5a1/product/Cell Signaling Technology Inc
    Average 90 stars, based on 10 article reviews
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    Cell Signaling Technology Inc cleaved caspase 3 asp175 5a1 rabbit monoclonal antibody
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Cleaved Caspase 3 Asp175 5a1 Rabbit Monoclonal Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cleaved caspase 3 asp175 5a1 rabbit monoclonal antibody/product/Cell Signaling Technology Inc
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    90
    Cell Signaling Technology Inc cleaved caspase 3 asp175 5a1 rabbit mab
    Dohh -mediated hypusination of <t>eIF-5A1</t> is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.
    Cleaved Caspase 3 Asp175 5a1 Rabbit Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cleaved caspase 3 asp175 5a1 rabbit mab/product/Cell Signaling Technology Inc
    Average 90 stars, based on 14 article reviews
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    N/A
    RUNX1 Monoclonal Antibody for Western Blot IF ICC
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    Image Search Results


    SUS analysis of TG and ABCA1 OPLS-DA models identifies potential directions for development of ligands with improved therapeutic profiles. SUS plot ( a ) and the corresponding p(corr) values mapped on the crystal structures of LXRα (2ACL.pdb) and LXRβ (1PQC.pdb) ( b ) according to shared color code. Dark green: p(corr) ABCA1 > 0.5, p(corr) TG

    Journal: Communications Biology

    Article Title: Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

    doi: 10.1038/s42003-019-0675-0

    Figure Lengend Snippet: SUS analysis of TG and ABCA1 OPLS-DA models identifies potential directions for development of ligands with improved therapeutic profiles. SUS plot ( a ) and the corresponding p(corr) values mapped on the crystal structures of LXRα (2ACL.pdb) and LXRβ (1PQC.pdb) ( b ) according to shared color code. Dark green: p(corr) ABCA1 > 0.5, p(corr) TG

    Article Snippet: In the other studies, 400 nM Abca1 forward and reverse primers, 200 nM Abca1 probe, 200 nM Rplp0 forward and reverse primers, and 100 nM Rplp0 probe were mixed with 15 ng of cDNA template and TaqMan™ Gene Expression Master Mix (Applied Biosystems, Foster City, USA).

    Techniques:

    Multivariate analysis reveals structural determinants of high intestine Abca1 induction. a PCA score scatter plot of the first two principal components. Green dots: LXR ligands inducing high intestine Abca1 levels, blue dots: low inducers of ABCA1, and gray dots: compounds with no assigned ABCA1 class. R 2 X(cum) = 83.4%, Q 2 (cum) = 62.9%, n = 17. b S plot of the ABCA1 OPLS-DA and the zoomed-in part of the plot representing limits used for the selection of differential peptides with the highest contribution to class separation (|p(corr)| > 0.7, p > 0.05). Orange dots: LXRα peptides, cyan dots: LXRβ peptides. c Statistically significant ( p -value

    Journal: Communications Biology

    Article Title: Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

    doi: 10.1038/s42003-019-0675-0

    Figure Lengend Snippet: Multivariate analysis reveals structural determinants of high intestine Abca1 induction. a PCA score scatter plot of the first two principal components. Green dots: LXR ligands inducing high intestine Abca1 levels, blue dots: low inducers of ABCA1, and gray dots: compounds with no assigned ABCA1 class. R 2 X(cum) = 83.4%, Q 2 (cum) = 62.9%, n = 17. b S plot of the ABCA1 OPLS-DA and the zoomed-in part of the plot representing limits used for the selection of differential peptides with the highest contribution to class separation (|p(corr)| > 0.7, p > 0.05). Orange dots: LXRα peptides, cyan dots: LXRβ peptides. c Statistically significant ( p -value

    Article Snippet: In the other studies, 400 nM Abca1 forward and reverse primers, 200 nM Abca1 probe, 200 nM Rplp0 forward and reverse primers, and 100 nM Rplp0 probe were mixed with 15 ng of cDNA template and TaqMan™ Gene Expression Master Mix (Applied Biosystems, Foster City, USA).

    Techniques: Selection

    Induction of macrophages genes by ATRA. (A) Mouse peritoneal macrophages in DMEM containing 10% LPDS were treated for 24 h with various concentrations of ATRA (0.1 to 5 μM) or vehicle (DMSO). (B) Human monocyte-derived macrophages were treated for 24 h with various concentrations of ATRA (0.5 to 5 μM) or vehicle (DMSO). The expression of ABCA1, ABCG1, SREBP-1c, apoE, and LXRα mRNA were measured by quantitative real-time PCR assays (TaqMan) and standardized against β-actin mRNA levels. ✽, P

    Journal: Molecular and Cellular Biology

    Article Title: Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

    doi: 10.1128/MCB.23.21.7756-7766.2003

    Figure Lengend Snippet: Induction of macrophages genes by ATRA. (A) Mouse peritoneal macrophages in DMEM containing 10% LPDS were treated for 24 h with various concentrations of ATRA (0.1 to 5 μM) or vehicle (DMSO). (B) Human monocyte-derived macrophages were treated for 24 h with various concentrations of ATRA (0.5 to 5 μM) or vehicle (DMSO). The expression of ABCA1, ABCG1, SREBP-1c, apoE, and LXRα mRNA were measured by quantitative real-time PCR assays (TaqMan) and standardized against β-actin mRNA levels. ✽, P

    Article Snippet: Membranes were probed with anti-ABCA1 antibody (Novus Biologicals, Littleton, Colo.) and anti-β-actin antibody (Sigma) according to the manufacturer's recommendations.

    Techniques: Derivative Assay, Expressing, Real-time Polymerase Chain Reaction

    Retinoids induce ABCA1 in macrophages. (A) Retinoids stimulate ABCA1-mediated cholesterol efflux from mouse peritoneal macrophages. The ability of macrophages to efflux cholesterol to apoA-I responds to ATRA treatment in a dose-dependent fashion. The results are expressed as mean ± the standard error of the mean (SEM; n = 4 ). ✽, P

    Journal: Molecular and Cellular Biology

    Article Title: Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

    doi: 10.1128/MCB.23.21.7756-7766.2003

    Figure Lengend Snippet: Retinoids induce ABCA1 in macrophages. (A) Retinoids stimulate ABCA1-mediated cholesterol efflux from mouse peritoneal macrophages. The ability of macrophages to efflux cholesterol to apoA-I responds to ATRA treatment in a dose-dependent fashion. The results are expressed as mean ± the standard error of the mean (SEM; n = 4 ). ✽, P

    Article Snippet: Membranes were probed with anti-ABCA1 antibody (Novus Biologicals, Littleton, Colo.) and anti-β-actin antibody (Sigma) according to the manufacturer's recommendations.

    Techniques:

    Dohh -mediated hypusination of eIF-5A1 is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.

    Journal: The Journal of Biological Chemistry

    Article Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System *

    doi: 10.1074/jbc.M115.664490

    Figure Lengend Snippet: Dohh -mediated hypusination of eIF-5A1 is essential in adult mice. A–D, analysis of adult Dohh +/+ , Dohh p/+ , and Dohh p/p -CAG-cre/Esr1 + -positive mice after 4-OHT administration resulting from a breeding according to the scheme in , B and C.

    Article Snippet: After washing, residual paraformaldehyde was quenched with 50 m m NH4 Cl in PBS for 10 min. For permeabilization, the cells were treated for 5 min with 0.1% (v/v) Triton X-100 in PBS, and then the samples were blocked with 0.5% (w/v) BSA in PBS for 30 min. Immunostaining was performed with mouse anti-eIF-5A1 (clone 26/eIF-5a; BD Biosciences) and Alexa Fluor 488-labeled goat anti-mouse antibody (Life Technologies, Inc.).

    Techniques: Mouse Assay

    Knockdown of the hypusine modification enzymes affect localization and post-translational modification of eIF-5A1. A, immunofluorescence for endogenous eIF-5A1 in a Dhs or Dohh -deficient cellular background, respectively. Upper panels depict eIF-5A1 fluorescence

    Journal: The Journal of Biological Chemistry

    Article Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System *

    doi: 10.1074/jbc.M115.664490

    Figure Lengend Snippet: Knockdown of the hypusine modification enzymes affect localization and post-translational modification of eIF-5A1. A, immunofluorescence for endogenous eIF-5A1 in a Dhs or Dohh -deficient cellular background, respectively. Upper panels depict eIF-5A1 fluorescence

    Article Snippet: After washing, residual paraformaldehyde was quenched with 50 m m NH4 Cl in PBS for 10 min. For permeabilization, the cells were treated for 5 min with 0.1% (v/v) Triton X-100 in PBS, and then the samples were blocked with 0.5% (w/v) BSA in PBS for 30 min. Immunostaining was performed with mouse anti-eIF-5A1 (clone 26/eIF-5a; BD Biosciences) and Alexa Fluor 488-labeled goat anti-mouse antibody (Life Technologies, Inc.).

    Techniques: Modification, Immunofluorescence, Fluorescence

    Loss of Dohh reveals histological anomalies. A, two-dimensional Western blot for eIF-5A1 in spleen tissue after 4-OHT treatment in vivo . Spleen was isolated from mice showing more than 20% weight loss. Colored arrows in the representative blots correspond

    Journal: The Journal of Biological Chemistry

    Article Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System *

    doi: 10.1074/jbc.M115.664490

    Figure Lengend Snippet: Loss of Dohh reveals histological anomalies. A, two-dimensional Western blot for eIF-5A1 in spleen tissue after 4-OHT treatment in vivo . Spleen was isolated from mice showing more than 20% weight loss. Colored arrows in the representative blots correspond

    Article Snippet: After washing, residual paraformaldehyde was quenched with 50 m m NH4 Cl in PBS for 10 min. For permeabilization, the cells were treated for 5 min with 0.1% (v/v) Triton X-100 in PBS, and then the samples were blocked with 0.5% (w/v) BSA in PBS for 30 min. Immunostaining was performed with mouse anti-eIF-5A1 (clone 26/eIF-5a; BD Biosciences) and Alexa Fluor 488-labeled goat anti-mouse antibody (Life Technologies, Inc.).

    Techniques: Western Blot, In Vivo, Isolation, Mouse Assay