Journal: Biochemical pharmacology

Article Title: Tropisetron enhances recognition memory in rats chronically treated with risperidone or quetiapine

doi: 10.1016/j.bcp.2017.11.017

Figure Lengend Snippet: Effects of risperidone 2.5 mg/kg/day (TOP) and quetiapine 25.0 mg/kg/day (Bottom) treatment in drinking water for 30 days on amphetamine (1.5 mg/kg s.c.)-induced locomotor activity in an open field arena. Amphetamine (AMP) was administered after a 60 min habituation period and the subjects were recorded for an additional 60 min period. For the risperidone evaluation, statistical analysis of ambulatory counts revealed the following, main effect of group, F(1,12) = 1.13, p=0.31, time period, F(23,276) = 55.74, p<0.001, group x time period interaction, F(23,276) = 1.95, p=0.007. In the quetiapine evaluation, statistical analysis revealed the following, main effect of group, F(1,13) = 2.93, p=0.11, time period, F(23,299) = 42.86, p<0.001, group x time period interaction, F(23,299) = 2.36, p<0.001. Data are expressed as the mean ± S.E.M. for each treatment group. * represents a significant difference (p<0.05 post hoc comparison) between the exploratory activity of antipsychotic-treated versus vehicle-treated (control) animals at the same respective time point. n = 7 per group.

Article Snippet: Quetiapine fumarate was purchased from Cerilliant (Round Rock, TX) and TCI America (Portland, OR), norquetiapine HCl, was purchased from Cerilliant (Round Rock, TX), midazolam was purchased from Hoffmann-La Roche (Nutley, NJ), and tropisetron was purchased from OChem Inc. (Des Plaines, IL).

Techniques: Activity Assay

Journal: Biochemical pharmacology

Article Title: Tropisetron enhances recognition memory in rats chronically treated with risperidone or quetiapine

doi: 10.1016/j.bcp.2017.11.017

Figure Lengend Snippet: Effects of quetiapine 25.0 mg/kg/day in drinking water for 30 days plus vehicle or tropisetron on the performance of a spontaneous novel object recognition task in rats. In these experiments, tropisetron (or vehicle) was administered by subcutaneous injection 30 min before the training (A/A) trial at the end of the antipsychotic treatment period. The mean (± S.E.M.) exploration times of the familiar and novel objects after 48 hr delays (A/B retention sessions) are illustrated in the main figures. The insets illustrate the mean (± S.E.M.) discrimination (d2) ratios. d2 ratio = (novel − familiar)/(novel + familiar). For exploration times, the following statistical results were obtained, main effect of group, F(3,28)=1.12, p=0.36, object type F(1,28)= 184.54, p<0.001), group x by object type interaction (F(3,28)= 60.02, p<0.001. For the D2 ratios, the following statistical results were obtained, F(3,28)=49.84, p<0.001. Post hoc results were as follows: +++p<0.001 novel vs familiar object; *** p<0.001 vs VEH-VEH. n=8 for each group. Abbreviations, VEH (vehicle), QUET (quetiapine), TROP (tropisetron).

Article Snippet: Quetiapine fumarate was purchased from Cerilliant (Round Rock, TX) and TCI America (Portland, OR), norquetiapine HCl, was purchased from Cerilliant (Round Rock, TX), midazolam was purchased from Hoffmann-La Roche (Nutley, NJ), and tropisetron was purchased from OChem Inc. (Des Plaines, IL).

Techniques: Injection

Journal: Biochemical pharmacology

Article Title: Tropisetron enhances recognition memory in rats chronically treated with risperidone or quetiapine

doi: 10.1016/j.bcp.2017.11.017

Figure Lengend Snippet: Effects of quetiapine 25.0 mg/kg/day in drinking water for 90 days plus vehicle or tropisetron on the performance of a spontaneous novel object recognition task in rats. In these experiments, tropisetron (or vehicle) was administered by subcutaneous injection 30 min before the training (A/A) trial at the end of the antipsychotic treatment period. The mean (± S.E.M.) exploration times of the familiar and novel objects after 48 hr delays (A/B retention sessions) are illustrated in the main figures. The insets illustrate the mean (± S.E.M.) discrimination (d2) ratios. d2 ratio = (novel − familiar)/(novel + familiar). For exploration times, the following statistical results were obtained main effect of group F(3,25)=0.47, p=0.71, object type F(1,25)= 76.51, p<0.001, group by object type interaction, F(3,25)= 6.38, p=0.002. For the D2 ratios, the following statistical results were obtained, F(3,25)=12.10, p<0.001. Post hoc results were as follows: +p<0.05, +++p<0.001 novel vs familiar object; *** p<0.001 vs VEH-VEH. n=7–8 for each group. Abbreviations, VEH (vehicle), QUET (quetiapine), TROP (tropisetron).

Article Snippet: Quetiapine fumarate was purchased from Cerilliant (Round Rock, TX) and TCI America (Portland, OR), norquetiapine HCl, was purchased from Cerilliant (Round Rock, TX), midazolam was purchased from Hoffmann-La Roche (Nutley, NJ), and tropisetron was purchased from OChem Inc. (Des Plaines, IL).

Techniques: Injection