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    Sino Biological sars cov 2 rbd protein
    A] Cell viability after incubation of Vero cells with imatinib for either 1 or 8 hours. and B] <t>SARS-CoV-2</t> neutralization profile post 1- and 8-hours exposure to imatinib. Inhibition of VSV pseudoparticles for SARS-CoV, SARS-CoV-2, MERS-CoV and VSV(control) after incubation with imatinib in C] Vero cells and D] Vero-TMPRSS2 cells. The red arrow indicates the concentration where no toxicity was observed microscopically anymore (15 nM). E] The association and dissociation curves obtained by BLI reflecting the binding of imatinib (0.78 to 6.25 µM) to immobilized SARS-CoV-2 RBD protein. Data fitted using the 1:1 binding model are shown in black.
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    A] Cell viability after incubation of Vero cells with imatinib for either 1 or 8 hours. and B] SARS-CoV-2 neutralization profile post 1- and 8-hours exposure to imatinib. Inhibition of VSV pseudoparticles for SARS-CoV, SARS-CoV-2, MERS-CoV and VSV(control) after incubation with imatinib in C] Vero cells and D] Vero-TMPRSS2 cells. The red arrow indicates the concentration where no toxicity was observed microscopically anymore (15 nM). E] The association and dissociation curves obtained by BLI reflecting the binding of imatinib (0.78 to 6.25 µM) to immobilized SARS-CoV-2 RBD protein. Data fitted using the 1:1 binding model are shown in black.

    Journal: bioRxiv

    Article Title: Bcr-Abl tyrosine kinase inhibitor imatinib as a potential drug for COVID-19

    doi: 10.1101/2020.06.18.158196

    Figure Lengend Snippet: A] Cell viability after incubation of Vero cells with imatinib for either 1 or 8 hours. and B] SARS-CoV-2 neutralization profile post 1- and 8-hours exposure to imatinib. Inhibition of VSV pseudoparticles for SARS-CoV, SARS-CoV-2, MERS-CoV and VSV(control) after incubation with imatinib in C] Vero cells and D] Vero-TMPRSS2 cells. The red arrow indicates the concentration where no toxicity was observed microscopically anymore (15 nM). E] The association and dissociation curves obtained by BLI reflecting the binding of imatinib (0.78 to 6.25 µM) to immobilized SARS-CoV-2 RBD protein. Data fitted using the 1:1 binding model are shown in black.

    Article Snippet: BLIThe binding kinetics of imatinib on SARS-CoV-2 RBD protein were studied using a BLItz® system (FortéBio).

    Techniques: Incubation, Neutralization, Inhibition, Concentration Assay, Binding Assay

    A] Docked poses of the selected compounds at the receptor-binding domain of SARS-CoV-2 spike protein (inset: conformation of imatinib from molecular dynamics simulations showing important interactions with the receptor at the active site). B] MM-GBSA binding free energies for the selected compounds with negative control DMSO. Error bars indicate standard deviations for sampling from a whole simulation. Tyrosine kinase inhibitors ponatinib and imatinib displayed a high affinity to the RBD of the spike protein.

    Journal: bioRxiv

    Article Title: Bcr-Abl tyrosine kinase inhibitor imatinib as a potential drug for COVID-19

    doi: 10.1101/2020.06.18.158196

    Figure Lengend Snippet: A] Docked poses of the selected compounds at the receptor-binding domain of SARS-CoV-2 spike protein (inset: conformation of imatinib from molecular dynamics simulations showing important interactions with the receptor at the active site). B] MM-GBSA binding free energies for the selected compounds with negative control DMSO. Error bars indicate standard deviations for sampling from a whole simulation. Tyrosine kinase inhibitors ponatinib and imatinib displayed a high affinity to the RBD of the spike protein.

    Article Snippet: BLIThe binding kinetics of imatinib on SARS-CoV-2 RBD protein were studied using a BLItz® system (FortéBio).

    Techniques: Binding Assay, Negative Control, Sampling