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  • 95
    Sino Biological recombinant ha
    Recombinant Ha, supplied by Sino Biological, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant ha/product/Sino Biological
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    recombinant ha - by Bioz Stars, 2021-06
    95/100 stars
      Buy from Supplier

    86
    Millipore 293t 17 hek 293t 17
    293t 17 Hek 293t 17, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/293t 17 hek 293t 17/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    293t 17 hek 293t 17 - by Bioz Stars, 2021-06
    86/100 stars
      Buy from Supplier

    94
    MedChemExpress tofacitinib treatment tofacitinib
    <t>Tofacitinib</t> and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p
    Tofacitinib Treatment Tofacitinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tofacitinib treatment tofacitinib/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tofacitinib treatment tofacitinib - by Bioz Stars, 2021-06
    94/100 stars
      Buy from Supplier

    86
    MedChemExpress tofacitinib mce
    <t>Tofacitinib</t> and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p
    Tofacitinib Mce, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tofacitinib mce/product/MedChemExpress
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tofacitinib mce - by Bioz Stars, 2021-06
    86/100 stars
      Buy from Supplier

    Image Search Results


    Tofacitinib and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p

    Journal: Scientific Reports

    Article Title: JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

    doi: 10.1038/s41598-021-86493-8

    Figure Lengend Snippet: Tofacitinib and Rapamycin partially rescues the lipodystrophic phenotype and improve the survival of Clec16a ΔUBC KO mice. ( A ) Representative dorsal and ventral dissection image depicting gross morphology and distribution of fat in Tofacitinib treated KO mice. ( B ) Body weight measured three times/week of tamoxifen control ± Tofacitnib and Clec16a KO ± Tofacitnib mice fed with standard chow. Data are presented as Mean ± SE, n = 15 mice/group. Two-way ANOVA. Tukey's multiple Comparison test, *p

    Article Snippet: Tofacitinib treatment Tofacitinib was purchased from Med Chem Express (Cat. HY-40354/CS-0050).

    Techniques: Mouse Assay, Dissection

    Tofacitnib mediated partial rescue of Clec16a ΔUBC KO phenotype. Model depicting loss of Clec16a leads to a vicious cycle of autophagic impairment and ER stress. ER stress activates lipolytic cascade. Excessive HSL-driven lipolysis stimulates inflammation in adipose tissue of KO mice. Tofacitinib exerts its multifaceted effect on HSL-mediated lipolysis, AMPK, mTOR, JAK-STATs, and autophagy/lipophagy and ER stress signaling, improves survival, and rescues the inflammatory lipodystrophic phenotype exhibited by Clec16a ΔUBC KO mice.

    Journal: Scientific Reports

    Article Title: JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

    doi: 10.1038/s41598-021-86493-8

    Figure Lengend Snippet: Tofacitnib mediated partial rescue of Clec16a ΔUBC KO phenotype. Model depicting loss of Clec16a leads to a vicious cycle of autophagic impairment and ER stress. ER stress activates lipolytic cascade. Excessive HSL-driven lipolysis stimulates inflammation in adipose tissue of KO mice. Tofacitinib exerts its multifaceted effect on HSL-mediated lipolysis, AMPK, mTOR, JAK-STATs, and autophagy/lipophagy and ER stress signaling, improves survival, and rescues the inflammatory lipodystrophic phenotype exhibited by Clec16a ΔUBC KO mice.

    Article Snippet: Tofacitinib treatment Tofacitinib was purchased from Med Chem Express (Cat. HY-40354/CS-0050).

    Techniques: Mouse Assay