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  • 93
    ATCC lmg 19886
    Lmg 19886, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lmg 19886/product/ATCC
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    lmg 19886 - by Bioz Stars, 2024-02
    93/100 stars
      Buy from Supplier

    93
    Proteintech anti phd2
    HIF2α-mediated GO terms involved in the development of <t>Phd2</t> -KO mediated spontaneous PH. (A) A representative waveform shows RVP (left) and statistical data (right) represents peak RVSP in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). Scale bars = 0.2 sec. (B) Statistical data of the RV/(LV + S) ratio shows RV hypertrophy defined by the Fulton index as a ratio [RV/(LV + S)] in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). (C) Typical H & E images of pulmonary arterioles from WT, Phd2 EC +/– and Phd2 EC – /– mice. Scale bars = 10 μm. (D) Statistical data shows PA wall thickness that generated by the ratio of wall area to total vessel area in PAs which were restricted less than 100 μm in diameter from WT, Phd2 EC +/– or Phd2 EC – /– mice ( n = 6). (E) Expression heatmap of the genes commonly deregulated in both hypoxia and Phd2 EC – /– deficient groups. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (F) Correlation in log 2 FC between hypoxia vs. normoxia mice ( X -axis) and Phd2 EC – /– vs. WT mice ( Y -axis) The correlation coefficient (r) and P -value were computed by Pearson correlation test. (G) Gene set score heatmap of the HIF2α-mediated GO biological process terms in WT and Phd2 EC – /– mice. In total, seven GO terms up-regulated in Phd2 EC – /– lungs were listed. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (H) Comparison of gene set score of the TGF-β signaling pathway between WT and Phd2 EC – /– mice. (I) Genotyping of WT and Phd2 EC +/– mice. PC1: positive control 1 ( Phd2 f /+ ), PC2: positive control 2 (Tie2-Cre +/– ), NC1: negative control 1 ( Phd2 +/+ ), NC2: negative control 2 (Tie2-Cre – /– ). (J) Relative expression of the PHD2 and HIF2α in mice lung tissues detected by western blotting with β-actin as control ( n = 3). Significance levels: * P < 0.05, ** P < 0.01 and *** P < 0.001 ( t -test).
    Anti Phd2, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti phd2/product/Proteintech
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    anti phd2 - by Bioz Stars, 2024-02
    93/100 stars
      Buy from Supplier

    93
    Proteintech 19886 1 ap
    HIF2α-mediated GO terms involved in the development of <t>Phd2</t> -KO mediated spontaneous PH. (A) A representative waveform shows RVP (left) and statistical data (right) represents peak RVSP in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). Scale bars = 0.2 sec. (B) Statistical data of the RV/(LV + S) ratio shows RV hypertrophy defined by the Fulton index as a ratio [RV/(LV + S)] in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). (C) Typical H & E images of pulmonary arterioles from WT, Phd2 EC +/– and Phd2 EC – /– mice. Scale bars = 10 μm. (D) Statistical data shows PA wall thickness that generated by the ratio of wall area to total vessel area in PAs which were restricted less than 100 μm in diameter from WT, Phd2 EC +/– or Phd2 EC – /– mice ( n = 6). (E) Expression heatmap of the genes commonly deregulated in both hypoxia and Phd2 EC – /– deficient groups. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (F) Correlation in log 2 FC between hypoxia vs. normoxia mice ( X -axis) and Phd2 EC – /– vs. WT mice ( Y -axis) The correlation coefficient (r) and P -value were computed by Pearson correlation test. (G) Gene set score heatmap of the HIF2α-mediated GO biological process terms in WT and Phd2 EC – /– mice. In total, seven GO terms up-regulated in Phd2 EC – /– lungs were listed. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (H) Comparison of gene set score of the TGF-β signaling pathway between WT and Phd2 EC – /– mice. (I) Genotyping of WT and Phd2 EC +/– mice. PC1: positive control 1 ( Phd2 f /+ ), PC2: positive control 2 (Tie2-Cre +/– ), NC1: negative control 1 ( Phd2 +/+ ), NC2: negative control 2 (Tie2-Cre – /– ). (J) Relative expression of the PHD2 and HIF2α in mice lung tissues detected by western blotting with β-actin as control ( n = 3). Significance levels: * P < 0.05, ** P < 0.01 and *** P < 0.001 ( t -test).
    19886 1 Ap, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/19886 1 ap/product/Proteintech
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    19886 1 ap - by Bioz Stars, 2024-02
    93/100 stars
      Buy from Supplier

    N/A
    Standard format Plasmid sent in bacteria as agar stab
      Buy from Supplier

    Image Search Results


    HIF2α-mediated GO terms involved in the development of Phd2 -KO mediated spontaneous PH. (A) A representative waveform shows RVP (left) and statistical data (right) represents peak RVSP in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). Scale bars = 0.2 sec. (B) Statistical data of the RV/(LV + S) ratio shows RV hypertrophy defined by the Fulton index as a ratio [RV/(LV + S)] in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). (C) Typical H & E images of pulmonary arterioles from WT, Phd2 EC +/– and Phd2 EC – /– mice. Scale bars = 10 μm. (D) Statistical data shows PA wall thickness that generated by the ratio of wall area to total vessel area in PAs which were restricted less than 100 μm in diameter from WT, Phd2 EC +/– or Phd2 EC – /– mice ( n = 6). (E) Expression heatmap of the genes commonly deregulated in both hypoxia and Phd2 EC – /– deficient groups. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (F) Correlation in log 2 FC between hypoxia vs. normoxia mice ( X -axis) and Phd2 EC – /– vs. WT mice ( Y -axis) The correlation coefficient (r) and P -value were computed by Pearson correlation test. (G) Gene set score heatmap of the HIF2α-mediated GO biological process terms in WT and Phd2 EC – /– mice. In total, seven GO terms up-regulated in Phd2 EC – /– lungs were listed. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (H) Comparison of gene set score of the TGF-β signaling pathway between WT and Phd2 EC – /– mice. (I) Genotyping of WT and Phd2 EC +/– mice. PC1: positive control 1 ( Phd2 f /+ ), PC2: positive control 2 (Tie2-Cre +/– ), NC1: negative control 1 ( Phd2 +/+ ), NC2: negative control 2 (Tie2-Cre – /– ). (J) Relative expression of the PHD2 and HIF2α in mice lung tissues detected by western blotting with β-actin as control ( n = 3). Significance levels: * P < 0.05, ** P < 0.01 and *** P < 0.001 ( t -test).

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Hypoxia-Inducible Factor 2-Alpha Mediated Gene Sets Differentiate Pulmonary Arterial Hypertension

    doi: 10.3389/fcell.2021.701247

    Figure Lengend Snippet: HIF2α-mediated GO terms involved in the development of Phd2 -KO mediated spontaneous PH. (A) A representative waveform shows RVP (left) and statistical data (right) represents peak RVSP in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). Scale bars = 0.2 sec. (B) Statistical data of the RV/(LV + S) ratio shows RV hypertrophy defined by the Fulton index as a ratio [RV/(LV + S)] in WT, Phd2 EC +/– and Phd2 EC – /– mice ( n = 6). (C) Typical H & E images of pulmonary arterioles from WT, Phd2 EC +/– and Phd2 EC – /– mice. Scale bars = 10 μm. (D) Statistical data shows PA wall thickness that generated by the ratio of wall area to total vessel area in PAs which were restricted less than 100 μm in diameter from WT, Phd2 EC +/– or Phd2 EC – /– mice ( n = 6). (E) Expression heatmap of the genes commonly deregulated in both hypoxia and Phd2 EC – /– deficient groups. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (F) Correlation in log 2 FC between hypoxia vs. normoxia mice ( X -axis) and Phd2 EC – /– vs. WT mice ( Y -axis) The correlation coefficient (r) and P -value were computed by Pearson correlation test. (G) Gene set score heatmap of the HIF2α-mediated GO biological process terms in WT and Phd2 EC – /– mice. In total, seven GO terms up-regulated in Phd2 EC – /– lungs were listed. Red and blue represent relative up-regulation and down-regulation of gene expression, respectively. (H) Comparison of gene set score of the TGF-β signaling pathway between WT and Phd2 EC – /– mice. (I) Genotyping of WT and Phd2 EC +/– mice. PC1: positive control 1 ( Phd2 f /+ ), PC2: positive control 2 (Tie2-Cre +/– ), NC1: negative control 1 ( Phd2 +/+ ), NC2: negative control 2 (Tie2-Cre – /– ). (J) Relative expression of the PHD2 and HIF2α in mice lung tissues detected by western blotting with β-actin as control ( n = 3). Significance levels: * P < 0.05, ** P < 0.01 and *** P < 0.001 ( t -test).

    Article Snippet: Antibodies that have been used are anti-HIF2α (Cat No. ab199, Abcam), anti-PHD2 (Cat No. 66589-1-Ig, Proteintech), and anti-β-actin (Cat No. 4970, Cell Signaling).

    Techniques: Generated, Expressing, Positive Control, Negative Control, Western Blot