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  • 80
    LC Laboratories 17 aag
    Photothermally activated release of the heat-shock protein 90 inhibitor drug, <t>17-AAG</t> from 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices (A) Diffusional release (leaching) of 17-AAG from the 17-AAG–C 12 ELP–GNR matrix was monitored for 24 h to a supernatant of phosphate-buffered saline (volume 500 μl). Approximately 10 μg of the drug was released in the first hour, following which minimal drug release was observed for the rest of the duration as seen in the cumulative data plotted above. The matrix was then subjected to laser irradiation for releasing the drug. During laser pulse-triggered release, the first laser irradiation lasted for 5 min (850 nm, 25 W/cm 2 ), the second to sixth laser irradiations (850 nm, 25 W/cm 2 ) were for 10 min, with 20-min interval without laser in between each irradiation. Data shown are mean ± standard deviation from four independent experiments (n = 4). (B) The temperature profile during 10-min laser exposure was monitored with a K-type thermocouple. The temperature reached 43–44°C (heat-shock conditions) following 5 min of laser irradiation, and remained invariant thereafter. Laser irradiation resulted in an additional 45–50 mg of 17-AAG released from the 17-AAG–C 12 ELP–GNR matrices, indicating the potential for combined hyperthermia and heat-shock inhibition. (C) Role of laser irradiation on enhancing 17-AAG release from C 12 ELP–GNR matrices. Matrices were first investigated for diffusional leaching of the drug, followed by incubation in a water bath at 42°C, and were finally irradiated with an near-infrared laser. Increased amounts of drug were released following laser treatment, presumably due to higher localized temperatures in the path of the laser. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod; HSP: Heat-shock protein.
    17 Aag, supplied by LC Laboratories, used in various techniques. Bioz Stars score: 80/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/17 aag/product/LC Laboratories
    Average 80 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    17 aag - by Bioz Stars, 2022-10
    80/100 stars
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    93
    Millipore 17 aag
    Photothermally activated release of the heat-shock protein 90 inhibitor drug, <t>17-AAG</t> from 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices (A) Diffusional release (leaching) of 17-AAG from the 17-AAG–C 12 ELP–GNR matrix was monitored for 24 h to a supernatant of phosphate-buffered saline (volume 500 μl). Approximately 10 μg of the drug was released in the first hour, following which minimal drug release was observed for the rest of the duration as seen in the cumulative data plotted above. The matrix was then subjected to laser irradiation for releasing the drug. During laser pulse-triggered release, the first laser irradiation lasted for 5 min (850 nm, 25 W/cm 2 ), the second to sixth laser irradiations (850 nm, 25 W/cm 2 ) were for 10 min, with 20-min interval without laser in between each irradiation. Data shown are mean ± standard deviation from four independent experiments (n = 4). (B) The temperature profile during 10-min laser exposure was monitored with a K-type thermocouple. The temperature reached 43–44°C (heat-shock conditions) following 5 min of laser irradiation, and remained invariant thereafter. Laser irradiation resulted in an additional 45–50 mg of 17-AAG released from the 17-AAG–C 12 ELP–GNR matrices, indicating the potential for combined hyperthermia and heat-shock inhibition. (C) Role of laser irradiation on enhancing 17-AAG release from C 12 ELP–GNR matrices. Matrices were first investigated for diffusional leaching of the drug, followed by incubation in a water bath at 42°C, and were finally irradiated with an near-infrared laser. Increased amounts of drug were released following laser treatment, presumably due to higher localized temperatures in the path of the laser. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod; HSP: Heat-shock protein.
    17 Aag, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/17 aag/product/Millipore
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    17 aag - by Bioz Stars, 2022-10
    93/100 stars
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    99
    InvivoGen 17 allylamino 17 demethoxygeldanamycin
    Photothermally activated release of the heat-shock protein 90 inhibitor drug, <t>17-AAG</t> from 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices (A) Diffusional release (leaching) of 17-AAG from the 17-AAG–C 12 ELP–GNR matrix was monitored for 24 h to a supernatant of phosphate-buffered saline (volume 500 μl). Approximately 10 μg of the drug was released in the first hour, following which minimal drug release was observed for the rest of the duration as seen in the cumulative data plotted above. The matrix was then subjected to laser irradiation for releasing the drug. During laser pulse-triggered release, the first laser irradiation lasted for 5 min (850 nm, 25 W/cm 2 ), the second to sixth laser irradiations (850 nm, 25 W/cm 2 ) were for 10 min, with 20-min interval without laser in between each irradiation. Data shown are mean ± standard deviation from four independent experiments (n = 4). (B) The temperature profile during 10-min laser exposure was monitored with a K-type thermocouple. The temperature reached 43–44°C (heat-shock conditions) following 5 min of laser irradiation, and remained invariant thereafter. Laser irradiation resulted in an additional 45–50 mg of 17-AAG released from the 17-AAG–C 12 ELP–GNR matrices, indicating the potential for combined hyperthermia and heat-shock inhibition. (C) Role of laser irradiation on enhancing 17-AAG release from C 12 ELP–GNR matrices. Matrices were first investigated for diffusional leaching of the drug, followed by incubation in a water bath at 42°C, and were finally irradiated with an near-infrared laser. Increased amounts of drug were released following laser treatment, presumably due to higher localized temperatures in the path of the laser. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod; HSP: Heat-shock protein.
    17 Allylamino 17 Demethoxygeldanamycin, supplied by InvivoGen, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/17 allylamino 17 demethoxygeldanamycin/product/InvivoGen
    Average 99 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    17 allylamino 17 demethoxygeldanamycin - by Bioz Stars, 2022-10
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    93
    Selleck Chemicals 17 aag
    Photothermally activated release of the heat-shock protein 90 inhibitor drug, <t>17-AAG</t> from 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices (A) Diffusional release (leaching) of 17-AAG from the 17-AAG–C 12 ELP–GNR matrix was monitored for 24 h to a supernatant of phosphate-buffered saline (volume 500 μl). Approximately 10 μg of the drug was released in the first hour, following which minimal drug release was observed for the rest of the duration as seen in the cumulative data plotted above. The matrix was then subjected to laser irradiation for releasing the drug. During laser pulse-triggered release, the first laser irradiation lasted for 5 min (850 nm, 25 W/cm 2 ), the second to sixth laser irradiations (850 nm, 25 W/cm 2 ) were for 10 min, with 20-min interval without laser in between each irradiation. Data shown are mean ± standard deviation from four independent experiments (n = 4). (B) The temperature profile during 10-min laser exposure was monitored with a K-type thermocouple. The temperature reached 43–44°C (heat-shock conditions) following 5 min of laser irradiation, and remained invariant thereafter. Laser irradiation resulted in an additional 45–50 mg of 17-AAG released from the 17-AAG–C 12 ELP–GNR matrices, indicating the potential for combined hyperthermia and heat-shock inhibition. (C) Role of laser irradiation on enhancing 17-AAG release from C 12 ELP–GNR matrices. Matrices were first investigated for diffusional leaching of the drug, followed by incubation in a water bath at 42°C, and were finally irradiated with an near-infrared laser. Increased amounts of drug were released following laser treatment, presumably due to higher localized temperatures in the path of the laser. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod; HSP: Heat-shock protein.
    17 Aag, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/17 aag/product/Selleck Chemicals
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    17 aag - by Bioz Stars, 2022-10
    93/100 stars
      Buy from Supplier

    Image Search Results


    Photothermally activated release of the heat-shock protein 90 inhibitor drug, 17-AAG from 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices (A) Diffusional release (leaching) of 17-AAG from the 17-AAG–C 12 ELP–GNR matrix was monitored for 24 h to a supernatant of phosphate-buffered saline (volume 500 μl). Approximately 10 μg of the drug was released in the first hour, following which minimal drug release was observed for the rest of the duration as seen in the cumulative data plotted above. The matrix was then subjected to laser irradiation for releasing the drug. During laser pulse-triggered release, the first laser irradiation lasted for 5 min (850 nm, 25 W/cm 2 ), the second to sixth laser irradiations (850 nm, 25 W/cm 2 ) were for 10 min, with 20-min interval without laser in between each irradiation. Data shown are mean ± standard deviation from four independent experiments (n = 4). (B) The temperature profile during 10-min laser exposure was monitored with a K-type thermocouple. The temperature reached 43–44°C (heat-shock conditions) following 5 min of laser irradiation, and remained invariant thereafter. Laser irradiation resulted in an additional 45–50 mg of 17-AAG released from the 17-AAG–C 12 ELP–GNR matrices, indicating the potential for combined hyperthermia and heat-shock inhibition. (C) Role of laser irradiation on enhancing 17-AAG release from C 12 ELP–GNR matrices. Matrices were first investigated for diffusional leaching of the drug, followed by incubation in a water bath at 42°C, and were finally irradiated with an near-infrared laser. Increased amounts of drug were released following laser treatment, presumably due to higher localized temperatures in the path of the laser. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod; HSP: Heat-shock protein.

    Journal: Nanomedicine (London, England)

    Article Title: Synergistic administration of photothermal therapy and chemotherapy to cancer cells using polypeptide-based degradable plasmonic matrices

    doi: 10.2217/nnm.10.133

    Figure Lengend Snippet: Photothermally activated release of the heat-shock protein 90 inhibitor drug, 17-AAG from 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices (A) Diffusional release (leaching) of 17-AAG from the 17-AAG–C 12 ELP–GNR matrix was monitored for 24 h to a supernatant of phosphate-buffered saline (volume 500 μl). Approximately 10 μg of the drug was released in the first hour, following which minimal drug release was observed for the rest of the duration as seen in the cumulative data plotted above. The matrix was then subjected to laser irradiation for releasing the drug. During laser pulse-triggered release, the first laser irradiation lasted for 5 min (850 nm, 25 W/cm 2 ), the second to sixth laser irradiations (850 nm, 25 W/cm 2 ) were for 10 min, with 20-min interval without laser in between each irradiation. Data shown are mean ± standard deviation from four independent experiments (n = 4). (B) The temperature profile during 10-min laser exposure was monitored with a K-type thermocouple. The temperature reached 43–44°C (heat-shock conditions) following 5 min of laser irradiation, and remained invariant thereafter. Laser irradiation resulted in an additional 45–50 mg of 17-AAG released from the 17-AAG–C 12 ELP–GNR matrices, indicating the potential for combined hyperthermia and heat-shock inhibition. (C) Role of laser irradiation on enhancing 17-AAG release from C 12 ELP–GNR matrices. Matrices were first investigated for diffusional leaching of the drug, followed by incubation in a water bath at 42°C, and were finally irradiated with an near-infrared laser. Increased amounts of drug were released following laser treatment, presumably due to higher localized temperatures in the path of the laser. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod; HSP: Heat-shock protein.

    Article Snippet: The diffusional release of 17-AAG from the matrix was monitored for 24 h. The laser beam was tuned to 2 mm in diameter for all near-infrared irradiation-triggered drug-release studies.

    Techniques: Irradiation, Standard Deviation, Inhibition, Incubation

    Spectrum of 17-AAG-loaded C 12 elastin-like polypeptide–gold nanorod matrices C 12 ELP–GNR matrices loaded with the heat-shock protein (HSP) 90 inhibitor drug, 17-AAG for ablation of cancer cells using a combination treatment of hyperthermia and HSP inhibition. (A) Absorbance spectrum 17-AAG shows a peak at approximately 330 nm, which is reflected in the 17-AAG–C 12 ELP–GNR matrices. (B) The inset in (B) shows a digital snapshot of the 17-AAG–C 12 ELP–GNR matrix loaded with 0.55 mg of the HSP90 inhibitor drug. Drug loading can also be seen from the change in color of the matrix. CTAB: Cetyltrimethylammonium bromide ELP: Elastin-like polypeptide; GNR: Gold nanorod.

    Journal: Nanomedicine (London, England)

    Article Title: Synergistic administration of photothermal therapy and chemotherapy to cancer cells using polypeptide-based degradable plasmonic matrices

    doi: 10.2217/nnm.10.133

    Figure Lengend Snippet: Spectrum of 17-AAG-loaded C 12 elastin-like polypeptide–gold nanorod matrices C 12 ELP–GNR matrices loaded with the heat-shock protein (HSP) 90 inhibitor drug, 17-AAG for ablation of cancer cells using a combination treatment of hyperthermia and HSP inhibition. (A) Absorbance spectrum 17-AAG shows a peak at approximately 330 nm, which is reflected in the 17-AAG–C 12 ELP–GNR matrices. (B) The inset in (B) shows a digital snapshot of the 17-AAG–C 12 ELP–GNR matrix loaded with 0.55 mg of the HSP90 inhibitor drug. Drug loading can also be seen from the change in color of the matrix. CTAB: Cetyltrimethylammonium bromide ELP: Elastin-like polypeptide; GNR: Gold nanorod.

    Article Snippet: The diffusional release of 17-AAG from the matrix was monitored for 24 h. The laser beam was tuned to 2 mm in diameter for all near-infrared irradiation-triggered drug-release studies.

    Techniques: Inhibition

    C 12 elastin-like polypeptide–gold nanorod matrices cell ablation set up with fluorescence (A B) and phase (C D) images PC3-PSMA human prostate cancer cells were cultured on C 12 ELP–GNR matrices (without 17-AAG drug) for 24 h, and irradiated with an 850-nm laser (25 W/cm 2 ) for 7 min. Viability of cells directly under the 1-mm laser irradiation spot (top; circled area) and outside the laser spot (bottom) was determined using the Live/Dead ® assay in which living cells stained green while dead cells stained red. Cells directly under the laser were killed by the hyperthermic treatment while those outside the laser irradiation spot were alive. Approximate locations of the images on the matrix are shown. Representative images are from two independent experiments (n = 2). Scale bar: 500 μm. ELP: Elastin-like polypeptide; GNR: Gold nanorod.

    Journal: Nanomedicine (London, England)

    Article Title: Synergistic administration of photothermal therapy and chemotherapy to cancer cells using polypeptide-based degradable plasmonic matrices

    doi: 10.2217/nnm.10.133

    Figure Lengend Snippet: C 12 elastin-like polypeptide–gold nanorod matrices cell ablation set up with fluorescence (A B) and phase (C D) images PC3-PSMA human prostate cancer cells were cultured on C 12 ELP–GNR matrices (without 17-AAG drug) for 24 h, and irradiated with an 850-nm laser (25 W/cm 2 ) for 7 min. Viability of cells directly under the 1-mm laser irradiation spot (top; circled area) and outside the laser spot (bottom) was determined using the Live/Dead ® assay in which living cells stained green while dead cells stained red. Cells directly under the laser were killed by the hyperthermic treatment while those outside the laser irradiation spot were alive. Approximate locations of the images on the matrix are shown. Representative images are from two independent experiments (n = 2). Scale bar: 500 μm. ELP: Elastin-like polypeptide; GNR: Gold nanorod.

    Article Snippet: The diffusional release of 17-AAG from the matrix was monitored for 24 h. The laser beam was tuned to 2 mm in diameter for all near-infrared irradiation-triggered drug-release studies.

    Techniques: Fluorescence, Cell Culture, Irradiation, Live Dead Assay, Staining

    17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices cell culture set up with fluorescence (A B) and phase (C D) images PC3-PSMA human prostate cancer cells were cultured on 17-AAG–C 12 ELP–GNR matrices for 48 h (no laser treatment) and viability of cells was determined using the Live/Dead ® assay. Diffusional release of 17-AAG from the matrix did not alter the viability of the cells. Approximate locations of the images on the matrix are shown. Representative images from three independent experiments (n = 3). Scale bar: 500 μm. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod.

    Journal: Nanomedicine (London, England)

    Article Title: Synergistic administration of photothermal therapy and chemotherapy to cancer cells using polypeptide-based degradable plasmonic matrices

    doi: 10.2217/nnm.10.133

    Figure Lengend Snippet: 17-AAG–C 12 elastin-like polypeptide–gold nanorod matrices cell culture set up with fluorescence (A B) and phase (C D) images PC3-PSMA human prostate cancer cells were cultured on 17-AAG–C 12 ELP–GNR matrices for 48 h (no laser treatment) and viability of cells was determined using the Live/Dead ® assay. Diffusional release of 17-AAG from the matrix did not alter the viability of the cells. Approximate locations of the images on the matrix are shown. Representative images from three independent experiments (n = 3). Scale bar: 500 μm. 17-AAG: 17-(allylamino)-17-demethoxygeldanamycin; ELP: Elastin-like polypeptide; GNR: Gold nanorod.

    Article Snippet: The diffusional release of 17-AAG from the matrix was monitored for 24 h. The laser beam was tuned to 2 mm in diameter for all near-infrared irradiation-triggered drug-release studies.

    Techniques: Cell Culture, Fluorescence, Live Dead Assay