ATCC
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Bio-Techne corporation
gap27 peptide ![]() Gap27 Peptide, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/gap27 peptide/product/Bio-Techne corporation Average 93 stars, based on 1 article reviews
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ATCC
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ATCC
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Addgene inc
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Image Search Results
![cx43 lh10 zebrafish exhibit pronounced cardiac defects. (A) Representative images of the heart region of WT and cx43 lh10 3 dpf embryos. cx43 lh10 embryos exhibit malformed, underdeveloped, and elongated hearts, bradycardia, and pericardial edema. (B) Quantification of WT and cx43 lh10 embryos at 2, 3, and 6 dpf indicates a significantly slower heart rate at all time points ( n = 100 for WT and cx43 lh10 embryos at 2, 3, and 6 dpf each, p ≤ 0.05). (C) Percentage of embryos exhibiting profound pericardial edema at 3 dpf ( n = 496 for WT and 468 for cx43 lh10 embryos, p ≤ 0.05). (D) Heart rates of uninjected 2 dpf cx43 lh10 embryos (UN, red), 2 dpf cx43 lh10 embryos injected with scrambled Gap27 peptide (SCRAM, blue), and 2 dpf cx43 lh10 embryos injected with Gap27 peptide inhibitor (green). Note that the heart rate of embryos injected with Gap27 was restored close to WT levels (compare A with D) ( n = 100 [uninfected], 21 [scrambled], 16 [Gap27 injected], p ≤ 0.05; error: SEM). (Also see Supplemental Movies 1 and 2.)](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_4743/pmc08684743/pmc08684743__mbc-32-ar13-g004.jpg)
Journal: Molecular Biology of the Cell
Article Title: Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish
doi: 10.1091/mbc.E20-12-0797
Figure Lengend Snippet: cx43 lh10 zebrafish exhibit pronounced cardiac defects. (A) Representative images of the heart region of WT and cx43 lh10 3 dpf embryos. cx43 lh10 embryos exhibit malformed, underdeveloped, and elongated hearts, bradycardia, and pericardial edema. (B) Quantification of WT and cx43 lh10 embryos at 2, 3, and 6 dpf indicates a significantly slower heart rate at all time points ( n = 100 for WT and cx43 lh10 embryos at 2, 3, and 6 dpf each, p ≤ 0.05). (C) Percentage of embryos exhibiting profound pericardial edema at 3 dpf ( n = 496 for WT and 468 for cx43 lh10 embryos, p ≤ 0.05). (D) Heart rates of uninjected 2 dpf cx43 lh10 embryos (UN, red), 2 dpf cx43 lh10 embryos injected with scrambled Gap27 peptide (SCRAM, blue), and 2 dpf cx43 lh10 embryos injected with Gap27 peptide inhibitor (green). Note that the heart rate of embryos injected with Gap27 was restored close to WT levels (compare A with D) ( n = 100 [uninfected], 21 [scrambled], 16 [Gap27 injected], p ≤ 0.05; error: SEM). (Also see Supplemental Movies 1 and 2.)
Article Snippet: The well-established GJ-specific mimetic peptide inhibitor, Gap27 ( ; Evans et al. , 2012 ) (Cat. No. 1476,
Techniques: Injection