Journal: Antimicrobial Agents and Chemotherapy
Article Title: Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections
Figure Lengend Snippet: Hollow-fiber infection model. The challenge strain (SPT719) used in this experiment is an ESBL-producing E. coli strain (tebipenem MIC, 0.03 mg/liter). Each panel represents the data from an individual fiber. The data represent the total bacterial population (open red triangles), a resistant subpopulation (open blue circles), and the pharmacokinetic profile of tebipenem (open black squares). The outputs from the mathematical model are shown using the same colors. The Bayesian posterior estimates for each fiber are shown. The fAUC0-24/MIC · 1/tau index values associated with the q24h, q12h, q8h, and q6h schedules are 17.3, 34.58, 51.87, and 69.15, respectively. Logarithmic killing was observed with at fAUC0-24/MIC · 1/tau values of 34.58 to 51.87, and suppression of resistance was observed at a value of 69.15. Panel A shows the control. In panels B to E, the same total amount of SPR859 has been administered in different schedules.
Article Snippet: The genotypes of the challenge strains are shown in . table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Species Strain identifier Genotype Modal (range) tebipenem MIC (mg/liter) E. coli NCTC 13462 CTX-M2 0.016 (0.016) E. coli ATCC 35218 TEM-1 ESBL 0.016 (0.008–0.016) E. coli ATCC 25922 Wild type 0.016 (0.008–0.016) E. coli SPT 719 (JMI 742654) SHV-12, TEM-1 0.03 (0.03–0.25) E. coli SPT 720 (JMI 850505) mcr-1 , CMY-2, OXA-1, TEM1 0.5 (0.25–0.5) E. coli SPT 731 (JMI 845741) CTX-M-15, OXA-1/30, TEM-1 ST131 a O25b clade 0.03 (0.015–0.03) K. pneumoniae NCTC 13465 ESBL and CTX-M25 0.03 (0.015–0.03) K. pneumoniae ATCC 27736 Wild type 0.03 (0.03–0.06) K. pneumoniae SPT 725 (JMI 776273) SHV-12 0.125 (0.06–0.25) K. pneumoniae SPT 722 (JMI 934954) CTX-M-15, OXA-1, OXA-9, SHV-28, TEM-1, OmpK35 disrupted, OmpK36 altered 0.25 (0.12–0.5) K. pneumoniae SPT 723 (JMI 632346) CTX-M-15, OXA-1, SHV-12 0.125 (0.12) Open in a separate window a ST131, sequence type 131.