1200 infinity series high performance liquid chromatography hplc system Search Results


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  • 99
    Agilent technologies 1200 infinity series hplc
    1200 Infinity Series Hplc, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 99/100, based on 524 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies hplc system
    Hplc System, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 95/100, based on 11481 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Agilent technologies 1200 infinity series high performance liquid chromatography hplc system
    1200 Infinity Series High Performance Liquid Chromatography Hplc System, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 88/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies infinity agilent 1100 1200 series hplc device
    Infinity Agilent 1100 1200 Series Hplc Device, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    Agilent technologies 1200 infinity series quaternary pump
    1200 Infinity Series Quaternary Pump, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 86/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Agilent technologies 1200 infinity series system
    1200 Infinity Series System, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies agilent hplc system
    Agilent Hplc System, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 99/100, based on 1518 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies hplc diode array detector
    Hplc Diode Array Detector, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 85/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies high performance liquid chromatography hplc instrument
    High Performance Liquid Chromatography Hplc Instrument, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 89/100, based on 86 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies high performance liquid chromatography
    High Performance Liquid Chromatography, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 99/100, based on 3343 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Agilent technologies reverse phase hplc
    Metabolite identification assay. MBX-2168 was exposed to mouse liver microsomes (MLMS), and metabolites were identified by LC-MS/MS analysis. (a) <t>HPLC</t> traces, including UV absorbance at 254 nm and extracted ion chromatographs representing all major metabolites. (b) Structures of notable peaks and relevant MS fragments. HPLC peak 1, <t>synguanol</t> metabolite; HPLC peak 2, metabolic product of oxidation of the butyl chain, identified by the presence of a synguanol MS fragment (peak at m / z 308.3 is from an isotope with higher molecular weight); HPLC peak 3, metabolic product of hydration at the cyclopropylidine substituent, identified by the presence of a MS fragment ( m / z 208.2); HPLC peak 4, metabolic product of oxidation at the core or cyclopropylidine substituent, identified by the presence of an oxidized synguanol MS fragment; HPLC peak 5, parent, MBX-2168 accompanied by significant levels of a synguanol MS fragment.
    Reverse Phase Hplc, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 94/100, based on 2244 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Metabolite identification assay. MBX-2168 was exposed to mouse liver microsomes (MLMS), and metabolites were identified by LC-MS/MS analysis. (a) HPLC traces, including UV absorbance at 254 nm and extracted ion chromatographs representing all major metabolites. (b) Structures of notable peaks and relevant MS fragments. HPLC peak 1, synguanol metabolite; HPLC peak 2, metabolic product of oxidation of the butyl chain, identified by the presence of a synguanol MS fragment (peak at m / z 308.3 is from an isotope with higher molecular weight); HPLC peak 3, metabolic product of hydration at the cyclopropylidine substituent, identified by the presence of a MS fragment ( m / z 208.2); HPLC peak 4, metabolic product of oxidation at the core or cyclopropylidine substituent, identified by the presence of an oxidized synguanol MS fragment; HPLC peak 5, parent, MBX-2168 accompanied by significant levels of a synguanol MS fragment.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1

    doi: 10.1128/AAC.01301-19

    Figure Lengend Snippet: Metabolite identification assay. MBX-2168 was exposed to mouse liver microsomes (MLMS), and metabolites were identified by LC-MS/MS analysis. (a) HPLC traces, including UV absorbance at 254 nm and extracted ion chromatographs representing all major metabolites. (b) Structures of notable peaks and relevant MS fragments. HPLC peak 1, synguanol metabolite; HPLC peak 2, metabolic product of oxidation of the butyl chain, identified by the presence of a synguanol MS fragment (peak at m / z 308.3 is from an isotope with higher molecular weight); HPLC peak 3, metabolic product of hydration at the cyclopropylidine substituent, identified by the presence of a MS fragment ( m / z 208.2); HPLC peak 4, metabolic product of oxidation at the core or cyclopropylidine substituent, identified by the presence of an oxidized synguanol MS fragment; HPLC peak 5, parent, MBX-2168 accompanied by significant levels of a synguanol MS fragment.

    Article Snippet: The MCPNAs (synguanol and MBX-2168), their phosphorylated derivatives (synguanol-MP and MBX-2168-MP), and adenosine/inosine were separated and quantified using reverse-phase HPLC (Agilent Technologies 1200 Infinity Series system, controlled by OpenLAB v1.3.4 software).

    Techniques: Liquid Chromatography with Mass Spectroscopy, High Performance Liquid Chromatography, Molecular Weight

    Enzymatic conversion of MBX-2168-MP to synguanol-MP by ADAL-1. The time-dependent formation of synguanol-MP (a) or IMP (b) was determined by incubating 100 μM MBX-2168-MP (a) or N 6 -methyl-AMP (NAMP) (b), respectively, with purified ADAL-1 and separating and quantifying the products via HPLC. The values represent the mean ± standard deviation from at least three experiments.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1

    doi: 10.1128/AAC.01301-19

    Figure Lengend Snippet: Enzymatic conversion of MBX-2168-MP to synguanol-MP by ADAL-1. The time-dependent formation of synguanol-MP (a) or IMP (b) was determined by incubating 100 μM MBX-2168-MP (a) or N 6 -methyl-AMP (NAMP) (b), respectively, with purified ADAL-1 and separating and quantifying the products via HPLC. The values represent the mean ± standard deviation from at least three experiments.

    Article Snippet: The MCPNAs (synguanol and MBX-2168), their phosphorylated derivatives (synguanol-MP and MBX-2168-MP), and adenosine/inosine were separated and quantified using reverse-phase HPLC (Agilent Technologies 1200 Infinity Series system, controlled by OpenLAB v1.3.4 software).

    Techniques: Purification, High Performance Liquid Chromatography, Standard Deviation