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A patient-derived next-generation organoid cancer model generated by the Human Cancer Models Initiative (HCMI). HCM-BROD-0477-C16 (ATCC No. PDM-489) was isolated from a metastatic cancer of the stomach; metastatic site: abdominal cavity. This tumor-derived model can
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Journal: Radiation Research
Article Title: Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device
doi: 10.1667/rr14656.1
Figure Lengend Snippet: FIG. 2. Urinary metabolic markers at days 1 and 7 postirradiation, based on comparison between equidoses and radiation type. L-phenylalanine, phenylpyruvic acid and N-decanoylglycine exhibited statistical significance when comparing 1 Gy neutrons vs. 1 Gy X rays at day 1. Phenylpyruvic acid, xanthurenic acid, decanoylcarnitine and sebacic acid were significantly different between the equidose groups at day 7. All data are presented as mean 6 SEM. *P , 0.05, **P , 0.01, ***P , 0.001 (Welch’s t test).
Article Snippet: Sphinganine-1phosphate was purchased from Avantit Polar Lipids, Inc. (Alabaster, AL), N-decanoyglycine from Hit2Lead (San Diego, CA) and
Techniques: Comparison
Journal: Radiation Research
Article Title: Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device
doi: 10.1667/rr14656.1
Figure Lengend Snippet: FIG. 4. ROC curves based on definitively identified metabolites and lipidomics results. AUC values of .0.9 indicate a high specificity and sensitivity of the combination of metabolites for selective identification based on different radiation quality. The six metabolites identified in urine (L-phenylalanine, N-decanoylglycine, phenylpyruvic acid, sebacic acid, xanthurenic acid and decanoylcarnitine) provide a separation of 1 Gy neutron from 1 Gy X rays with high specificity and sensitivity at both days 1 and 7 postirradiation, as demonstrated by the high arch of the curve. The serum signature, on the other hand (metabolomics and lipidomics markers), exhibited high specificity and sensitivity only on day 1, with generally low AUC levels at day 7.
Article Snippet: Sphinganine-1phosphate was purchased from Avantit Polar Lipids, Inc. (Alabaster, AL), N-decanoyglycine from Hit2Lead (San Diego, CA) and
Techniques: