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Image Search Results
Journal: Molecular Brain
Article Title: Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
doi: 10.1186/s13041-022-00984-x
Figure Lengend Snippet: Effects of CHRM subtype-selective agonists and antagonists on CHRM density and locomotor activity in DD mice. ( a – c ) Binding assays with [ 3 H]pirenzepine, [ 3 H]AFDX-384, and [ 3 H]4-DAMP were conducted. WT mice: n = 5, DD mice: n = 5. ** p < 0.01 (Student’s t -test). The data are expressed as the mean + SEM with data point overlap. ( d - h ) Change in locomotor activity in WT mice ( n = 11–12) and DD mice ( n = 9–12) following xanomeline, arecaidine propargyl ester tosylate, VU0255035, AQRA-741, and saline treatment. * p < 0.05, ** p < 0.01 (two-way repeated-measures ANOVA). The data are expressed as the mean ± SEM
Article Snippet: Xanomeline (CHRM1/CHRM4 agonist; 10 mg/kg; Tocris Bioscience, Bristol, UK),
Techniques: Activity Assay, Binding Assay, Saline