Journal: Analytical and Bioanalytical Chemistry
Article Title: Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry
Figure Lengend Snippet: ACh has the highest intrinsic sensitivity among the six assessed neurotransmitters in MALDI-MS. Shown are the intrinsic sensitivity evaluation results of the six neurotransmitters using MALDI-MS with the use of α-cyano-4-hydroxycinnamic acid. The plotted signal intensity values are the difference values between the sample-containing and blank m / z signal intensities ( Y -axis, arbitrary units), whereas the X -axis is the analyte concentration on a log 10 scale. The R 2 values of each collinear approximation are also shown. The values of the x -intercept shown in Table 1 represent the detection sensitivity of MALDI-IMS for the six neurotransmitters
Article Snippet: Norepinephrine was purchased from Wako Pure Chemical Industries Ltd. (Osaka, Japan). α-Cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) were obtained from Bruker Daltonics (Leipzig, Germany).
Techniques: Mass Spectrometry, Concentration Assay