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    • oseltamivir carboxylate  (Toronto Research Chemicals)
    92
    Toronto Research Chemicals oseltamivir carboxylate
    (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI <t>oseltamivir</t> shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).
    Oseltamivir Carboxylate, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/oseltamivir carboxylate/product/Toronto Research Chemicals
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    oseltamivir carboxylate - by Bioz Stars, 2023-03
    92/100 stars
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    phospho akt  (Cell Signaling Technology Inc)
    94
    Cell Signaling Technology Inc phospho akt
    (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI <t>oseltamivir</t> shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).
    Phospho Akt, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospho akt/product/Cell Signaling Technology Inc
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    phospho akt - by Bioz Stars, 2023-03
    94/100 stars
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    wm276  (ATCC)
    91
    ATCC wm276
    (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI <t>oseltamivir</t> shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).
    Wm276, supplied by ATCC, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/wm276/product/ATCC
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    wm276 - by Bioz Stars, 2023-03
    91/100 stars
    		  Buy from Supplier
    oseltamivir carboxylic acid  (Toronto Research Chemicals)
    85
    Toronto Research Chemicals oseltamivir carboxylic acid
    (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI <t>oseltamivir</t> shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).
    Oseltamivir Carboxylic Acid, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/oseltamivir carboxylic acid/product/Toronto Research Chemicals
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    oseltamivir carboxylic acid - by Bioz Stars, 2023-03
    85/100 stars
    		  Buy from Supplier
    4071 staffordshire  (Jenway Inc)
    86
    Jenway Inc 4071 staffordshire
    (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI <t>oseltamivir</t> shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).
    4071 Staffordshire, supplied by Jenway Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4071 staffordshire/product/Jenway Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    4071 staffordshire - by Bioz Stars, 2023-03
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI oseltamivir shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).

    Journal: Cell

    Article Title: Low fidelity assembly of influenza A virus promotes escape from host cells

    doi: 10.1016/j.cell.2018.10.056

    Figure Lengend Snippet: (A) Comparing the heterogeneity of populations of virus exposed to NAIs that are able to detach from infected cells (red dotted circle) to those that cannot (blue dotted circle). (B) Treatment with physiological doses of the NAI oseltamivir shifts the phenotype of released viruses towards lower HA and higher NA abundance (top row). Viruses that remain bound under these conditions have predominantly high-HA phenotypes (“+exo. NA”, bottom row). Percentages give the number of particles within the gated region defined by dashed lines. Data from individual replicates are plotted in Figure S7A and tabulated in Supplemental Data 2. (C) Comparison of HA-NA ratio in viruses released under different challenge (“NAI”) or permissive (“exo. NA”) conditions. Viruses that release from NAI-treated cells have significantly lower HA/NA ratios than those that release in the absence of inhibitor or in the presence of both inhibitor and exogenous NA. Bars represent mean +/− S.D. for population medians, with the number of replicates (n) given below each condition (p-values determined using a two-sample T-test). (D) Composition of filamentous viruses (L > 1µm) released under challenge and/or permissive conditions. While the density of HA on filamentous particles (total HA intensity divided by particle length) does not change, filamentous viruses shed from cells challenged with NAI show a slight but significant increase in NA density. Bars represent mean +/− S.D. for population medians measured in four independent experiments with between 499 and 2067 filamentous viruses each (p-values determined using a two-sample T-test). (E) Measuring the propensity of viruses to detach from sialic acid coated coverslips as a function of their shape and composition. (F) Viruses that detach within a 1 hr observation period have significantly lower HA/NA ratios and significantly shorter lengths, as shown in (G). Quantification is based on three independent experiments with N > 366 released viruses and N > 991 attached viruses recorded in each. Data from individual experiments are plotted in Figure S7B. P-values calculated using a two-sample K-S test (F) and a two-sample T-test (G).

    Article Snippet: After incubating cells with virus for one hour at 37°C, we wash to remove excess virus, replacing media with virus growth media supplemented with or without a specified concentration of oseltamivir carboxylate (Toronto Research Chemicals O700980), but without TPCK-treated trypsin.

    Techniques: Infection

    KEY RESOURCES TABLE

    Journal: Cell

    Article Title: Low fidelity assembly of influenza A virus promotes escape from host cells

    doi: 10.1016/j.cell.2018.10.056

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: After incubating cells with virus for one hour at 37°C, we wash to remove excess virus, replacing media with virus growth media supplemented with or without a specified concentration of oseltamivir carboxylate (Toronto Research Chemicals O700980), but without TPCK-treated trypsin.

    Techniques: Recombinant, Cell Culture, Software