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    • isosorbide dinitrate  (Toronto Research Chemicals)
    85
    Toronto Research Chemicals isosorbide dinitrate
    Isosorbide Dinitrate, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/isosorbide dinitrate/product/Toronto Research Chemicals
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    isosorbide dinitrate - by Bioz Stars, 2023-03
    85/100 stars
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    cx43  (Cell Signaling Technology Inc)
    93
    Cell Signaling Technology Inc cx43
    Cx43, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cx43/product/Cell Signaling Technology Inc
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cx43 - by Bioz Stars, 2023-03
    93/100 stars
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    momlv gag pol  (ATCC)
    94
    ATCC momlv gag pol
    Momlv Gag Pol, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/momlv gag pol/product/ATCC
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    momlv gag pol - by Bioz Stars, 2023-03
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    ace2  (ProSci Incorporated)
    93
    ProSci Incorporated ace2
    Histologic and molecular correlates of COVID-19 in human brains. Panel A shows the microvessels in normal brain. In comparison, many of the capillaries in COVID-19 brain tissues show marked perivascular edema (panel B). Serial section analyses of the COVID-19 brain shows that the endothelial cells of the microvessels contained the spike glycoprotein (panel C), the <t>ACE2</t> receptor (panel D) and IL 6 (panel F), but not viral RNA (panel E). The fluorescent yellow signal marks co-localization of the spike protein with IL6 (panel G) and caspase 3 (panel H), respectively, in these endothelial cells. Each magnification is 800× with DAB (brown) signal (panels C, E, F) or Fast Red (red) (panel D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
    Ace2, supplied by ProSci Incorporated, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ace2/product/ProSci Incorporated
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ace2 - by Bioz Stars, 2023-03
    93/100 stars
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    fluorogenic substrate benzyloxycarbonyl l histidyl l glutamyl l lysine 4 methyl coumaryl 7 amide  (Biosynth Carbosynth)
    88
    Biosynth Carbosynth fluorogenic substrate benzyloxycarbonyl l histidyl l glutamyl l lysine 4 methyl coumaryl 7 amide
    Histologic and molecular correlates of COVID-19 in human brains. Panel A shows the microvessels in normal brain. In comparison, many of the capillaries in COVID-19 brain tissues show marked perivascular edema (panel B). Serial section analyses of the COVID-19 brain shows that the endothelial cells of the microvessels contained the spike glycoprotein (panel C), the <t>ACE2</t> receptor (panel D) and IL 6 (panel F), but not viral RNA (panel E). The fluorescent yellow signal marks co-localization of the spike protein with IL6 (panel G) and caspase 3 (panel H), respectively, in these endothelial cells. Each magnification is 800× with DAB (brown) signal (panels C, E, F) or Fast Red (red) (panel D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
    Fluorogenic Substrate Benzyloxycarbonyl L Histidyl L Glutamyl L Lysine 4 Methyl Coumaryl 7 Amide, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fluorogenic substrate benzyloxycarbonyl l histidyl l glutamyl l lysine 4 methyl coumaryl 7 amide/product/Biosynth Carbosynth
    Average 88 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    fluorogenic substrate benzyloxycarbonyl l histidyl l glutamyl l lysine 4 methyl coumaryl 7 amide - by Bioz Stars, 2023-03
    88/100 stars
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    Image Search Results


    Histologic and molecular correlates of COVID-19 in human brains. Panel A shows the microvessels in normal brain. In comparison, many of the capillaries in COVID-19 brain tissues show marked perivascular edema (panel B). Serial section analyses of the COVID-19 brain shows that the endothelial cells of the microvessels contained the spike glycoprotein (panel C), the ACE2 receptor (panel D) and IL 6 (panel F), but not viral RNA (panel E). The fluorescent yellow signal marks co-localization of the spike protein with IL6 (panel G) and caspase 3 (panel H), respectively, in these endothelial cells. Each magnification is 800× with DAB (brown) signal (panels C, E, F) or Fast Red (red) (panel D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

    Journal: Annals of Diagnostic Pathology

    Article Title: Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

    doi: 10.1016/j.anndiagpath.2020.151682

    Figure Lengend Snippet: Histologic and molecular correlates of COVID-19 in human brains. Panel A shows the microvessels in normal brain. In comparison, many of the capillaries in COVID-19 brain tissues show marked perivascular edema (panel B). Serial section analyses of the COVID-19 brain shows that the endothelial cells of the microvessels contained the spike glycoprotein (panel C), the ACE2 receptor (panel D) and IL 6 (panel F), but not viral RNA (panel E). The fluorescent yellow signal marks co-localization of the spike protein with IL6 (panel G) and caspase 3 (panel H), respectively, in these endothelial cells. Each magnification is 800× with DAB (brown) signal (panels C, E, F) or Fast Red (red) (panel D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The antibodies used follow; ABCAM, Cambridge MA (IL6, TNFα, NMDAR2, SHIP1, caspase 3, and C5b-9), Enzo Life Sciences (neuronal NOS, MFSD2a), ACE2 (PROSCI, Poway CA) (cat # 3215) and optimal pretreatment in each case was 30 min with the Leica EDTA antigen retrieval solution.

    Techniques:

    Quantification of cell line data after incubation with different subunits of the SARS-CoV2 spike protein.

    Journal: Annals of Diagnostic Pathology

    Article Title: Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

    doi: 10.1016/j.anndiagpath.2020.151682

    Figure Lengend Snippet: Quantification of cell line data after incubation with different subunits of the SARS-CoV2 spike protein.

    Article Snippet: The antibodies used follow; ABCAM, Cambridge MA (IL6, TNFα, NMDAR2, SHIP1, caspase 3, and C5b-9), Enzo Life Sciences (neuronal NOS, MFSD2a), ACE2 (PROSCI, Poway CA) (cat # 3215) and optimal pretreatment in each case was 30 min with the Leica EDTA antigen retrieval solution.

    Techniques: Incubation

    Cytologic and molecular correlates of the S1 subunit of the spike protein in cell lines. Panel A shows the cytology of untreated HUVEC cells; these endothelial cells strongly express ACE2 (panel B). Treatment with the S1 subunit of spike protein induced cell aggregation and degeneration (panel C). The S1 subunit was not endocytosed by the RAW cells (panel D) and was evident in the HUVEC cells where it co-localized with caspase 3 as seen in panels F-H. Panel F is the isolated spike data (fluorescent green), panel G the isolated caspase 3 data (fluorescent red) and panel H the merged image with fluorescent yellow marking the co-localization of the two protein. The MN cells likewise showed co-localization of the spike protein and caspase 3 (panel E). The magnifications are 600× (panels A-D) and 1000× (panels E -F) with DAB (brown) signal (panel D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

    Journal: Annals of Diagnostic Pathology

    Article Title: Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

    doi: 10.1016/j.anndiagpath.2020.151682

    Figure Lengend Snippet: Cytologic and molecular correlates of the S1 subunit of the spike protein in cell lines. Panel A shows the cytology of untreated HUVEC cells; these endothelial cells strongly express ACE2 (panel B). Treatment with the S1 subunit of spike protein induced cell aggregation and degeneration (panel C). The S1 subunit was not endocytosed by the RAW cells (panel D) and was evident in the HUVEC cells where it co-localized with caspase 3 as seen in panels F-H. Panel F is the isolated spike data (fluorescent green), panel G the isolated caspase 3 data (fluorescent red) and panel H the merged image with fluorescent yellow marking the co-localization of the two protein. The MN cells likewise showed co-localization of the spike protein and caspase 3 (panel E). The magnifications are 600× (panels A-D) and 1000× (panels E -F) with DAB (brown) signal (panel D). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The antibodies used follow; ABCAM, Cambridge MA (IL6, TNFα, NMDAR2, SHIP1, caspase 3, and C5b-9), Enzo Life Sciences (neuronal NOS, MFSD2a), ACE2 (PROSCI, Poway CA) (cat # 3215) and optimal pretreatment in each case was 30 min with the Leica EDTA antigen retrieval solution.

    Techniques: Isolation