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z138  (ATCC)
96
ATCC z138
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Z138, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/pmc13147429-30-2-10?v=ATCC
Average 96 stars, based on 1 article reviews
z138 - by Bioz Stars, 2026-08
96/100 stars
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z-fy-cho  (MedChemExpress)
94
MedChemExpress z-fy-cho
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Z Fy Cho, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/custom%40hy-128140%4042527662?v=MedChemExpress
Average 94 stars, based on 1 article reviews
z-fy-cho - by Bioz Stars, 2026-08
94/100 stars
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z-plbpa-2  (Echelon Biosciences)
93
Echelon Biosciences z-plbpa-2
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Z Plbpa 2, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/custom%40z-plbpa-2%4042484373?v=Echelon+Biosciences
Average 93 stars, based on 1 article reviews
z-plbpa-2 - by Bioz Stars, 2026-08
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2(z)-hexadecenoic acid  (Larodan)
90
Larodan 2(z)-hexadecenoic acid
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
2(z) Hexadecenoic Acid, supplied by Larodan, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/custom%4010-1609%4042421310?v=Larodan
Average 90 stars, based on 1 article reviews
2(z)-hexadecenoic acid - by Bioz Stars, 2026-08
90/100 stars
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z-arg-arg-amc  (Millipore)
90
Millipore z-arg-arg-amc
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Z Arg Arg Amc, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/10__22175_slash_mmb__17760-115-39-42?v=Millipore
Average 90 stars, based on 1 article reviews
z-arg-arg-amc - by Bioz Stars, 2026-08
90/100 stars
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composite z score  (CogState Ltd)
90
CogState Ltd composite z score
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Composite Z Score, supplied by CogState Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/nct04939597-26-7-7?v=CogState+Ltd
Average 90 stars, based on 1 article reviews
composite z score - by Bioz Stars, 2026-08
90/100 stars
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piezo z stage  (Physik Instrumente)
86
Physik Instrumente piezo z stage
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Piezo Z Stage, supplied by Physik Instrumente, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/pmc13254718-169-31-34?v=Physik+Instrumente
Average 86 stars, based on 1 article reviews
piezo z stage - by Bioz Stars, 2026-08
86/100 stars
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purified anti-ptdins(3)p igg  (Echelon Biosciences)
94
Echelon Biosciences purified anti-ptdins(3)p igg
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Purified Anti Ptdins(3)p Igg, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/custom%40z-p003%4042444607?v=Echelon+Biosciences
Average 94 stars, based on 1 article reviews
purified anti-ptdins(3)p igg - by Bioz Stars, 2026-08
94/100 stars
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z-devd-fmk  (MedChemExpress)
96
MedChemExpress z-devd-fmk
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Z Devd Fmk, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/custom%40hy-12466%4042468796?v=MedChemExpress
Average 96 stars, based on 1 article reviews
z-devd-fmk - by Bioz Stars, 2026-08
96/100 stars
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nano z zetasizer  (Malvern Panalytical)
86
Malvern Panalytical nano z zetasizer
APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in <t>Z138</t> and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.
Nano Z Zetasizer, supplied by Malvern Panalytical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/z/pmc12972744-523-14-16?v=Malvern+Panalytical
Average 86 stars, based on 1 article reviews
nano z zetasizer - by Bioz Stars, 2026-08
86/100 stars
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Image Search Results


APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in Z138 and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.

Journal: Translational Oncology

Article Title: Eprenetapopt in combination with Palbociclib exerts synthetic lethality in mantle cell lymphoma

doi: 10.1016/j.tranon.2026.102794

Figure Lengend Snippet: APR-246 and PD0332991 show synergistic effects on MCL cell lines in vitro . (A) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in MCL cell lines was assessed by CCK-8 assay (N = 3). (B) CI values for APR-246 and PD0332991 were calculated in MCL cell lines (N = 3). (C) p53 expression were detected in Z138 and Jeko-1 cells with stably expressing modified p53 alleles (p53-WT, p53-R273H) and in Mino cell with knockdown p53 by Western blot, following with the statistical chart (N = 3). (D) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (E) CI values for APR-246 and PD0332991 were calculated in Z138 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (F) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) were assessed by CCK-8 assay (N = 3). (G) CI values for APR-246 and PD0332991 were calculated in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H) (N = 3). (H) Inhibition of cell proliferation by the combination of APR-246 and PD0332991 in Mino cells with knockdown p53 were assessed by CCK-8 assay (N = 3). (I) CI values for APR-246 and PD0332991 were calculated in Mino cells with knockdown p53 (N = 3). (J) GSEA showed more significantly enrichment of the DNA repair pathways in mut/delp53 cell lines than wtp53 cell lines (from public repositories DepMap) (P.adjust < 0.05). (I) Normalized enrichment score of the DNA repair pathways. N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA followed by Dunnett’s multiple comparisons test and the student’s t-test. CI values were analyzed by CompuSyn. CI <0.9 Synergism, 0.9≤CI≤1.1 Additive, CI ≥1.1 Antagonism.** P < 0.01; *** P < 0.001; **** P < 0.0001.

Article Snippet: Mino, Jeko-1, Z138, and Granta-519 cell lines were obtained from ATCC (Manassas, USA).

Techniques: In Vitro, Inhibition, CCK-8 Assay, Expressing, Stable Transfection, Modification, Knockdown, Western Blot, Variant Assay

APR-246 and PD0332991 show synergistic cytotoxic effects on mut/delp53 MCL cell lines in vitro . (A) ROS levels measured by H 2 DCFDA-based flow cytometry in MCL cell lines, following with the statistical chart (N = 3). (B) ROS levels measured by H 2 DCFDA-based flow cytometry in Z138 cells with modified p53 alleles (p53-WT, p53-R273H), following with the statistical chart (N = 3). (C) ROS levels measured by H 2 DCFDA-based flow cytometry in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H), following with the statistical chart (N = 3). (D)ROS levels measured by H 2 DCFDA-based flow cytometry in Mino cells with knockdown p53, following with the statistical chart (N = 3). (E) DNA strand damage in mutp53 and delp53 MCL cell lines treated with the combination of APR-246 and PD0332991 was assessed by comet assay, following with the statistical chart (N = 3). (F) Apoptosis induced by the combination of APR-246 and PD0332991 in mutp53 and delp53 MCL cell lines was detected by flow cytometry, following with the statistical chart (N = 3). (G) Expression of apoptosis- and DNA damage-related proteins in mutp53 and delp53 MCL cell lines were analyzed by Western blot, following with the statistical chart (N = 3). N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA or Two-way ANOVA followed by Tukey’s or Sidak’s multiple comparisons test and the student’s t-test. ** P < 0.01; *** P < 0.001; **** P < 0.0001. NAC:N-acetylcysteine, the ROS scavenger.

Journal: Translational Oncology

Article Title: Eprenetapopt in combination with Palbociclib exerts synthetic lethality in mantle cell lymphoma

doi: 10.1016/j.tranon.2026.102794

Figure Lengend Snippet: APR-246 and PD0332991 show synergistic cytotoxic effects on mut/delp53 MCL cell lines in vitro . (A) ROS levels measured by H 2 DCFDA-based flow cytometry in MCL cell lines, following with the statistical chart (N = 3). (B) ROS levels measured by H 2 DCFDA-based flow cytometry in Z138 cells with modified p53 alleles (p53-WT, p53-R273H), following with the statistical chart (N = 3). (C) ROS levels measured by H 2 DCFDA-based flow cytometry in Jeko-1 cells with modified p53 alleles (p53-WT, p53-R273H), following with the statistical chart (N = 3). (D)ROS levels measured by H 2 DCFDA-based flow cytometry in Mino cells with knockdown p53, following with the statistical chart (N = 3). (E) DNA strand damage in mutp53 and delp53 MCL cell lines treated with the combination of APR-246 and PD0332991 was assessed by comet assay, following with the statistical chart (N = 3). (F) Apoptosis induced by the combination of APR-246 and PD0332991 in mutp53 and delp53 MCL cell lines was detected by flow cytometry, following with the statistical chart (N = 3). (G) Expression of apoptosis- and DNA damage-related proteins in mutp53 and delp53 MCL cell lines were analyzed by Western blot, following with the statistical chart (N = 3). N = 3 independent experiments for each cell line and cell variant. Data are presented as mean ± S.D. Statistical analyses were performed using Ordinary one ANOVA or Two-way ANOVA followed by Tukey’s or Sidak’s multiple comparisons test and the student’s t-test. ** P < 0.01; *** P < 0.001; **** P < 0.0001. NAC:N-acetylcysteine, the ROS scavenger.

Article Snippet: Mino, Jeko-1, Z138, and Granta-519 cell lines were obtained from ATCC (Manassas, USA).

Techniques: In Vitro, Flow Cytometry, Modification, Knockdown, Single Cell Gel Electrophoresis, Expressing, Western Blot, Variant Assay