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MedChemExpress piezo1 activator yoda1
A Representative western blot images of <t>Piezo1</t> in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with Dooku1 (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
Piezo1 Activator Yoda1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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TargetMol yoda1
A Representative western blot images of <t>Piezo1</t> in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with Dooku1 (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
Yoda1, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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MedChemExpress yoda1 antagonist dooku1
A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with <t>Dooku1</t> (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
Yoda1 Antagonist Dooku1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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MedChemExpress yoda1
A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with <t>Dooku1</t> (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
Yoda1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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MedChemExpress yoda1 medchemexpress hy
A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with <t>Dooku1</t> (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
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Tocris yoda1
A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with <t>Dooku1</t> (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
Yoda1, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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MedChemExpress hy y0320 yoda1 mce
A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM <t>Yoda1.</t> E Calcium responses in BMSCs pre-treated with <t>Dooku1</t> (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.
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A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM Yoda1. E Calcium responses in BMSCs pre-treated with Dooku1 (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.

Journal: Nature Communications

Article Title: Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling

doi: 10.1038/s41467-026-78462-4

Figure Lengend Snippet: A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM Yoda1. E Calcium responses in BMSCs pre-treated with Dooku1 (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.

Article Snippet: Piezo1 activator Yoda1 (Cat No. HY-18723, MCE, China) and Yoda1 antagonist Dooku1 (Cat No. HY-126010, MCE, China) were used to pharmacologically modulate the activity of Piezo1.

Techniques: Western Blot, Staining, Cell Culture, Comparison

A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM Yoda1. E Calcium responses in BMSCs pre-treated with Dooku1 (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.

Journal: Nature Communications

Article Title: Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling

doi: 10.1038/s41467-026-78462-4

Figure Lengend Snippet: A Representative western blot images of Piezo1 in BMSCs. B Quantification of Piezo1 protein levels; n = 3 biological replications, data were presented as mean values ± SD; error bars = SD. C Schematic illustrating Piezo1-mediated mechanotransduction. Created in BioRender. Chen, Y. (2026) https://BioRender.com/nwwp37d . D Real-time intracellular calcium dynamics in BMSCs treated with 0, 5, 10, or 20 μM Yoda1. E Calcium responses in BMSCs pre-treated with Dooku1 (0-20 μM) followed by 10 μM Yoda1. F Alizarin Red S and G ALP staining of BMSCs treated with Yoda1 and/or Dooku1. H Calcium dynamics in BMSCs cultured on Ti, UMTS, or MMTS with/without EMF. I Calcium responses in Dooku1-pre-treated BMSCs under the same conditions. J Fluorescent staining of primary cilia (green, anti-acetylated tubulin, indicated with white arrows), and nuclei (blue, DAPI). K Alizarin red staining and L ALP staining. M Schematic illustrating the importance of primary cilia in BMSCs in perceiving mechanical stimulation. a.u. denotes arbitrary units. Created in BioRender. Chen, Y. (2026) https://BioRender.com/tb5ct1c . Data were compared by one-way ANOVA followed by Tukey’s multiple comparison test. Source data are provided as a file.

Article Snippet: Piezo1 activator Yoda1 (Cat No. HY-18723, MCE, China) and Yoda1 antagonist Dooku1 (Cat No. HY-126010, MCE, China) were used to pharmacologically modulate the activity of Piezo1.

Techniques: Western Blot, Staining, Cell Culture, Comparison