x500b qtof mass spectrometer  (SCIEX)

 
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    SCIEX x500b qtof mass spectrometer
    HR MS and MS/MS spectra of MPI8 and MPI8•H 2 O using an extracted sample from MPI8 spiked plasma at retention time of 4.5 min after column elution on an <t>X500B</t> <t>QTOF</t> <t>mass</t> <t>spectrometer;</t> ( A1 , A2 ) and ( B1 , B2 ) in positive mode, ( C1 , C2 ) and ( D1 , D2 ) in negative mode; the proposed fragmentation of product ions are shown on MS/MS spectra: ( A1 ) protonated MPI8 [MPI8 + H] + MS ( m / z 601.3594), ( A2 ) protonated MPI8 [MPI8 + H] + MS/MS; ( B1 ) [MPI8•H 2 O + Na] + MS ( m / z 641.3502) ( B2 ) [MPI8•H 2 O + Na] + MS/MS; ( C1 ) deprotonated MPI8 [MPI8 −H] − MS ( m / z 599.3433), ( C2 ) deprotonated MPI8 [MPI8 − H] − MS/MS; ( D1 ) [MPI8•H 2 O + Cl] − MS ( m / z 653.3325), ( D2 ) [MPI8•H 2 O + Cl] − MS/MS.
    X500b Qtof Mass Spectrometer, supplied by SCIEX, used in various techniques. Bioz Stars score: 86/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/x500b qtof mass spectrometer/product/SCIEX
    Average 86 stars, based on 9 article reviews
    Price from $9.99 to $1999.99
    x500b qtof mass spectrometer - by Bioz Stars, 2022-08
    86/100 stars

    Images

    1) Product Images from "Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies"

    Article Title: Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies

    Journal: Pharmaceuticals

    doi: 10.3390/ph15060676

    HR MS and MS/MS spectra of MPI8 and MPI8•H 2 O using an extracted sample from MPI8 spiked plasma at retention time of 4.5 min after column elution on an X500B QTOF mass spectrometer; ( A1 , A2 ) and ( B1 , B2 ) in positive mode, ( C1 , C2 ) and ( D1 , D2 ) in negative mode; the proposed fragmentation of product ions are shown on MS/MS spectra: ( A1 ) protonated MPI8 [MPI8 + H] + MS ( m / z 601.3594), ( A2 ) protonated MPI8 [MPI8 + H] + MS/MS; ( B1 ) [MPI8•H 2 O + Na] + MS ( m / z 641.3502) ( B2 ) [MPI8•H 2 O + Na] + MS/MS; ( C1 ) deprotonated MPI8 [MPI8 −H] − MS ( m / z 599.3433), ( C2 ) deprotonated MPI8 [MPI8 − H] − MS/MS; ( D1 ) [MPI8•H 2 O + Cl] − MS ( m / z 653.3325), ( D2 ) [MPI8•H 2 O + Cl] − MS/MS.
    Figure Legend Snippet: HR MS and MS/MS spectra of MPI8 and MPI8•H 2 O using an extracted sample from MPI8 spiked plasma at retention time of 4.5 min after column elution on an X500B QTOF mass spectrometer; ( A1 , A2 ) and ( B1 , B2 ) in positive mode, ( C1 , C2 ) and ( D1 , D2 ) in negative mode; the proposed fragmentation of product ions are shown on MS/MS spectra: ( A1 ) protonated MPI8 [MPI8 + H] + MS ( m / z 601.3594), ( A2 ) protonated MPI8 [MPI8 + H] + MS/MS; ( B1 ) [MPI8•H 2 O + Na] + MS ( m / z 641.3502) ( B2 ) [MPI8•H 2 O + Na] + MS/MS; ( C1 ) deprotonated MPI8 [MPI8 −H] − MS ( m / z 599.3433), ( C2 ) deprotonated MPI8 [MPI8 − H] − MS/MS; ( D1 ) [MPI8•H 2 O + Cl] − MS ( m / z 653.3325), ( D2 ) [MPI8•H 2 O + Cl] − MS/MS.

    Techniques Used: Tandem Mass Spectroscopy, Mass Spectrometry

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    • x500b qtof mass spectrometer  (SCIEX)
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    SCIEX x500b qtof mass spectrometer
    HR MS and MS/MS spectra of MPI8 and MPI8•H 2 O using an extracted sample from MPI8 spiked plasma at retention time of 4.5 min after column elution on an <t>X500B</t> <t>QTOF</t> <t>mass</t> <t>spectrometer;</t> ( A1 , A2 ) and ( B1 , B2 ) in positive mode, ( C1 , C2 ) and ( D1 , D2 ) in negative mode; the proposed fragmentation of product ions are shown on MS/MS spectra: ( A1 ) protonated MPI8 [MPI8 + H] + MS ( m / z 601.3594), ( A2 ) protonated MPI8 [MPI8 + H] + MS/MS; ( B1 ) [MPI8•H 2 O + Na] + MS ( m / z 641.3502) ( B2 ) [MPI8•H 2 O + Na] + MS/MS; ( C1 ) deprotonated MPI8 [MPI8 −H] − MS ( m / z 599.3433), ( C2 ) deprotonated MPI8 [MPI8 − H] − MS/MS; ( D1 ) [MPI8•H 2 O + Cl] − MS ( m / z 653.3325), ( D2 ) [MPI8•H 2 O + Cl] − MS/MS.
    X500b Qtof Mass Spectrometer, supplied by SCIEX, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/x500b qtof mass spectrometer/product/SCIEX
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    x500b qtof mass spectrometer - by Bioz Stars, 2022-08
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    HR MS and MS/MS spectra of MPI8 and MPI8•H 2 O using an extracted sample from MPI8 spiked plasma at retention time of 4.5 min after column elution on an X500B QTOF mass spectrometer; ( A1 , A2 ) and ( B1 , B2 ) in positive mode, ( C1 , C2 ) and ( D1 , D2 ) in negative mode; the proposed fragmentation of product ions are shown on MS/MS spectra: ( A1 ) protonated MPI8 [MPI8 + H] + MS ( m / z 601.3594), ( A2 ) protonated MPI8 [MPI8 + H] + MS/MS; ( B1 ) [MPI8•H 2 O + Na] + MS ( m / z 641.3502) ( B2 ) [MPI8•H 2 O + Na] + MS/MS; ( C1 ) deprotonated MPI8 [MPI8 −H] − MS ( m / z 599.3433), ( C2 ) deprotonated MPI8 [MPI8 − H] − MS/MS; ( D1 ) [MPI8•H 2 O + Cl] − MS ( m / z 653.3325), ( D2 ) [MPI8•H 2 O + Cl] − MS/MS.

    Journal: Pharmaceuticals

    Article Title: Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies

    doi: 10.3390/ph15060676

    Figure Lengend Snippet: HR MS and MS/MS spectra of MPI8 and MPI8•H 2 O using an extracted sample from MPI8 spiked plasma at retention time of 4.5 min after column elution on an X500B QTOF mass spectrometer; ( A1 , A2 ) and ( B1 , B2 ) in positive mode, ( C1 , C2 ) and ( D1 , D2 ) in negative mode; the proposed fragmentation of product ions are shown on MS/MS spectra: ( A1 ) protonated MPI8 [MPI8 + H] + MS ( m / z 601.3594), ( A2 ) protonated MPI8 [MPI8 + H] + MS/MS; ( B1 ) [MPI8•H 2 O + Na] + MS ( m / z 641.3502) ( B2 ) [MPI8•H 2 O + Na] + MS/MS; ( C1 ) deprotonated MPI8 [MPI8 −H] − MS ( m / z 599.3433), ( C2 ) deprotonated MPI8 [MPI8 − H] − MS/MS; ( D1 ) [MPI8•H 2 O + Cl] − MS ( m / z 653.3325), ( D2 ) [MPI8•H 2 O + Cl] − MS/MS.

    Article Snippet: The identification for MPI8•H2 O was performed on an X500B QTOF mass spectrometer (SCIEX, Framingham, MA, USA) using a Synergi Fusion-RP column (4 µm, 150 × 2 mm, 80 Å, Phenomenex, Torrance, CA, USA).

    Techniques: Tandem Mass Spectroscopy, Mass Spectrometry