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Image Search Results


(A) Body weight change of healthy control mice, DEN-induced HCC mice, and DEN-induced HCC mice treated with either doxorubicin (DOX) or idarubicin (IDA). (B) Relative spleen ratio. (C) Number of macroscopic tumors (D) Quantified relative tumor area from tissue sections. (E) Quantified Ki-67 positive cells from tissue sections (F) Representative images of tissue sections stained with hematoxylin and eosin (H&E) and immunohistochemical staining for Ki-67. Each data point represents one mouse. N = 5-10 mice per group. All data is expressed as mean ± SEM. Scale bars represent 100 µm.

Journal: bioRxiv

Article Title: A comparative study of the chemotoxic effects of idarubicin and doxorubicin in a chemically-induced in vivo mouse model and in vitro models for hepatocellular carcinoma

doi: 10.1101/2025.03.14.643356

Figure Lengend Snippet: (A) Body weight change of healthy control mice, DEN-induced HCC mice, and DEN-induced HCC mice treated with either doxorubicin (DOX) or idarubicin (IDA). (B) Relative spleen ratio. (C) Number of macroscopic tumors (D) Quantified relative tumor area from tissue sections. (E) Quantified Ki-67 positive cells from tissue sections (F) Representative images of tissue sections stained with hematoxylin and eosin (H&E) and immunohistochemical staining for Ki-67. Each data point represents one mouse. N = 5-10 mice per group. All data is expressed as mean ± SEM. Scale bars represent 100 µm.

Article Snippet: Chemicals used during experiments were diethylnitrosamine (DEN; 1002877809, Sigma-Aldrich, Darmstadt, Germany, diluted in saline), doxorubicin (Doxorubicin Accord 2 mg/mL; Vnr 189790; diluted in saline), idarubicin (Zavedos®; Pfizer; Vnr 08 08 20; diluted in saline or DMSO).

Techniques: Control, Staining, Immunohistochemical staining

Cell viability curves of HCC cell lines (Huh7 and HepG2) treated with anthracyclines Doxorubicin and Idarubicin for 24 hours (A-F). Cell viability curves of Huh7 (A), HepG2 (B) and LX-2 (C) cells treated with DOX and IDA on monolayer. (D) Cell viability curves of Huh7 and HepG2 spheroids treated with DOX and IDA. (E) Cell viability curves of Huh7-LX-2 and HepG2-LX-2 spheroids treated with DOX and IDA. Each data point represents the averaged values of six technical replicates from one independent experiment. N = 2 independent experiment. Data is expressed as mean ± SEM.

Journal: bioRxiv

Article Title: A comparative study of the chemotoxic effects of idarubicin and doxorubicin in a chemically-induced in vivo mouse model and in vitro models for hepatocellular carcinoma

doi: 10.1101/2025.03.14.643356

Figure Lengend Snippet: Cell viability curves of HCC cell lines (Huh7 and HepG2) treated with anthracyclines Doxorubicin and Idarubicin for 24 hours (A-F). Cell viability curves of Huh7 (A), HepG2 (B) and LX-2 (C) cells treated with DOX and IDA on monolayer. (D) Cell viability curves of Huh7 and HepG2 spheroids treated with DOX and IDA. (E) Cell viability curves of Huh7-LX-2 and HepG2-LX-2 spheroids treated with DOX and IDA. Each data point represents the averaged values of six technical replicates from one independent experiment. N = 2 independent experiment. Data is expressed as mean ± SEM.

Article Snippet: Chemicals used during experiments were diethylnitrosamine (DEN; 1002877809, Sigma-Aldrich, Darmstadt, Germany, diluted in saline), doxorubicin (Doxorubicin Accord 2 mg/mL; Vnr 189790; diluted in saline), idarubicin (Zavedos®; Pfizer; Vnr 08 08 20; diluted in saline or DMSO).

Techniques:

Journal: bioRxiv

Article Title: A comparative study of the chemotoxic effects of idarubicin and doxorubicin in a chemically-induced in vivo mouse model and in vitro models for hepatocellular carcinoma

doi: 10.1101/2025.03.14.643356

Figure Lengend Snippet:

Article Snippet: Chemicals used during experiments were diethylnitrosamine (DEN; 1002877809, Sigma-Aldrich, Darmstadt, Germany, diluted in saline), doxorubicin (Doxorubicin Accord 2 mg/mL; Vnr 189790; diluted in saline), idarubicin (Zavedos®; Pfizer; Vnr 08 08 20; diluted in saline or DMSO).

Techniques: