Journal: Frontiers in Pharmacology
Article Title: Nephroprotective Effects of Benzyl Isothiocyanate and Resveratrol Against Cisplatin-Induced Oxidative Stress and Inflammation
Figure Lengend Snippet: COX-II immunohistochemical examination (Bar = 50 μm) of renal tissue samples from (A) saline-treated mice showing minimal COX-II expression, (B) cisplatin-intoxicated mice revealing many Cox-II-positive epithelial cells (arrows), (C) cisplatin-intoxicated mice treated with RES and (D) cisplatin-intoxicated mice treated with BITC showing moderate reductions in COX-II-positive cells (arrow), and (E) cisplatin-intoxicated mice treated with a combination of RES and BITC showing minimal COX-II expression. (F) Quantitative Cox-II expression in the cytoplasm of renal epithelial cells ( ∗ significantly different from the normal control group at p
Article Snippet: Chemicals Cisplatin (1 mg/ml vial) in a clinical formulation and BITC were obtained from Sigma (St. Louis, MO, United States), while RES was bought from NOW Foods (IL, United States).
Techniques: Immunohistochemistry, Mouse Assay, Expressing