vascular label fitc concanavalin a (Vector Laboratories)
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Name:
Unconjugated Concanavalin A Con A
Description:
Concanavalin A Con A recognizes α linked mannose present as part of a core oligosaccharide in many serum and membrane glycoproteins At neutral and alkaline pH Con A exists as a tetramer of four identical subunits below pH 5 6 Con A dissociates into active dimers of 52 kDa Acetylation succinylation or other derivatizations can also produce stable forms with dimeric structures See succinylated Con A Nicks in the sequence are often present in the purest preparations due to hydrolytic damage within the seeds Con A requires calcium or manganese ions at each of its four saccharide binding sites Although these divalent metal ions are bound tightly to the polypeptide structure buffers which can bind calcium such as phosphate generally should be avoided in diluting Con A since a gradual loss in activity may occur Inhibiting Eluting Sugar mixture of 200 mM α methylmannoside 200 mM α methylglucoside
Catalog Number:
L-1000
Price:
None
Category:
Proteins
Size:
500 mg
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Structured Review
Vector Laboratories
vascular label fitc concanavalin a
Concanavalin A Con A recognizes α linked mannose present as part of a core oligosaccharide in many serum and membrane glycoproteins At neutral and alkaline pH Con A exists as a tetramer of four identical subunits below pH 5 6 Con A dissociates into active dimers of 52 kDa Acetylation succinylation or other derivatizations can also produce stable forms with dimeric structures See succinylated Con A Nicks in the sequence are often present in the purest preparations due to hydrolytic damage within the seeds Con A requires calcium or manganese ions at each of its four saccharide binding sites Although these divalent metal ions are bound tightly to the polypeptide structure buffers which can bind calcium such as phosphate generally should be avoided in diluting Con A since a gradual loss in activity may occur Inhibiting Eluting Sugar mixture of 200 mM α methylmannoside 200 mM α methylglucoside
https://www.bioz.com/result/vascular label fitc concanavalin a/product/Vector Laboratories
Average 95 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Concanavalin A Con A recognizes α linked mannose present as part of a core oligosaccharide in many serum and membrane glycoproteins At neutral and alkaline pH Con A exists as a tetramer of four identical subunits below pH 5 6 Con A dissociates into active dimers of 52 kDa Acetylation succinylation or other derivatizations can also produce stable forms with dimeric structures See succinylated Con A Nicks in the sequence are often present in the purest preparations due to hydrolytic damage within the seeds Con A requires calcium or manganese ions at each of its four saccharide binding sites Although these divalent metal ions are bound tightly to the polypeptide structure buffers which can bind calcium such as phosphate generally should be avoided in diluting Con A since a gradual loss in activity may occur Inhibiting Eluting Sugar mixture of 200 mM α methylmannoside 200 mM α methylglucoside
https://www.bioz.com/result/vascular label fitc concanavalin a/product/Vector Laboratories
Average 95 stars, based on 1 article reviews
Price from $9.99 to $1999.99
vascular label fitc concanavalin a - by Bioz Stars,
2021-04
95/100 stars
Images
1) Product Images from "Pharmacologic Uncoupling of Angiogenesis and Inflammation during Initiation of Pathological Corneal Neovascularization *"
Article Title: Pharmacologic Uncoupling of Angiogenesis and Inflammation during Initiation of Pathological Corneal Neovascularization *
Journal: The Journal of Biological Chemistry
doi: 10.1074/jbc.M111.294967
Figure Legend Snippet: Epithelial debridement induces rapid and consistent corneal angiogenesis and inflammation by 3 days. A , representative FITC-concanavalin A-injected corneal flat mounts at various times over 20 days following epithelial debridement. B , quantification of total vascular area per cornea normalized to control (undebrided) limbal vessel areas ( n = 10 corneas/group). Error bars indicate S.E. NV Area , neovascular area. C , H E-stained corneal sections showing the progression of re-epithelialization over a matter of days. The images are all oriented with the limbus to the left ( L ) and the central cornea to the right ( C ). Note the repair epithelium at the wound edge ( arrowhead ) accompanied by underlying inflammatory infiltrates. By day 7, the cornea completely resurfaced with a stratified epithelium ( E ) but includes the presence of new shallow stromal vessels ( S ) ( arrows ). The presence of inflammatory cells was reduced by this time (20×).
Techniques Used: Injection, Staining
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