unimpaired probdnf  (Alomone Labs)


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    Alomone Labs unimpaired probdnf
    Memory impairment in aged mice positively correlates with increases in hippocampal <t>proBDNF</t> levels. (A) Average (±SEM) reference memory (RM) and working memory (WM) errors over four 4-session blocks of a WRAM task in 24-month old aged mice and 4-month old young mice. RM and WM errors positively correlate with proBDNF levels. (B) Increase in proBDNF, but not brain-derived neurotrophic factor (BDNF), in 24-month old aged mice relative to young 4-month old mice. (C) Relative to young 4-month old mice, aged 24-month old mice show increased p75 Neurotrophin Receptor (p75NTR) and decreased p-trk140 and trk140. (D) Relative to young 4-month old mice, aged 24-month old mice show decreased Tissue Plasminogen Activator (tPA), but not carboxypeptidase E (CPE). * p
    Unimpaired Probdnf, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/unimpaired probdnf/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    unimpaired probdnf - by Bioz Stars, 2022-10
    95/100 stars

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    1) Product Images from "Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice"

    Article Title: Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

    Journal: Frontiers in Aging Neuroscience

    doi: 10.3389/fnagi.2017.00284

    Memory impairment in aged mice positively correlates with increases in hippocampal proBDNF levels. (A) Average (±SEM) reference memory (RM) and working memory (WM) errors over four 4-session blocks of a WRAM task in 24-month old aged mice and 4-month old young mice. RM and WM errors positively correlate with proBDNF levels. (B) Increase in proBDNF, but not brain-derived neurotrophic factor (BDNF), in 24-month old aged mice relative to young 4-month old mice. (C) Relative to young 4-month old mice, aged 24-month old mice show increased p75 Neurotrophin Receptor (p75NTR) and decreased p-trk140 and trk140. (D) Relative to young 4-month old mice, aged 24-month old mice show decreased Tissue Plasminogen Activator (tPA), but not carboxypeptidase E (CPE). * p
    Figure Legend Snippet: Memory impairment in aged mice positively correlates with increases in hippocampal proBDNF levels. (A) Average (±SEM) reference memory (RM) and working memory (WM) errors over four 4-session blocks of a WRAM task in 24-month old aged mice and 4-month old young mice. RM and WM errors positively correlate with proBDNF levels. (B) Increase in proBDNF, but not brain-derived neurotrophic factor (BDNF), in 24-month old aged mice relative to young 4-month old mice. (C) Relative to young 4-month old mice, aged 24-month old mice show increased p75 Neurotrophin Receptor (p75NTR) and decreased p-trk140 and trk140. (D) Relative to young 4-month old mice, aged 24-month old mice show decreased Tissue Plasminogen Activator (tPA), but not carboxypeptidase E (CPE). * p

    Techniques Used: Mouse Assay, Derivative Assay

    Theoretical model of the role of proBDNF in learning in memory in aged individuals. In young individuals, maturation of proBDNF to BDNF is controlled by plasmin and tPA, and is essential for learning and memory. Aged individuals show decreased levels of tPA and plasmin, and increased levels of uncleaved proBDNF, associated with increased spine remodeling and memory deficits. Blockade of p75NTR (e.g., by TAT-Pep5, as in the current study) leads to spine growth, and rescues learning and memory.
    Figure Legend Snippet: Theoretical model of the role of proBDNF in learning in memory in aged individuals. In young individuals, maturation of proBDNF to BDNF is controlled by plasmin and tPA, and is essential for learning and memory. Aged individuals show decreased levels of tPA and plasmin, and increased levels of uncleaved proBDNF, associated with increased spine remodeling and memory deficits. Blockade of p75NTR (e.g., by TAT-Pep5, as in the current study) leads to spine growth, and rescues learning and memory.

    Techniques Used:

    Timeline of Experiments 1 and 2. In Experiment 2, mice were split into three groups based on their performance (unimpaired/impaired) and henceforth infused with different drugs (saline, proBDNF, TAT-Pep5). d, day of study; WRAM, behavioral training/testing in the water radial arm maze task; SAL, saline.
    Figure Legend Snippet: Timeline of Experiments 1 and 2. In Experiment 2, mice were split into three groups based on their performance (unimpaired/impaired) and henceforth infused with different drugs (saline, proBDNF, TAT-Pep5). d, day of study; WRAM, behavioral training/testing in the water radial arm maze task; SAL, saline.

    Techniques Used: Mouse Assay

    Intra-hippocampal infusion of proBDNF impairs memory in well-performing (unimpaired) mice, while TAT-Pep5 infusion improves memory in poorly-performing (impaired) mice. (A) Average (±SEM) RM and WM errors in memory impaired 18-month old mice receiving intra-hippocampal saline infusions (impaired + SAL, n = 8, open triangles) and well-performing 18-month old aged mice receiving uncleavable proBDNF intra-hippocampal infusions (unimpaired + proBDNF, n = 16, open circles) over four daily sessions of a WRAM task. (B) Average (± SEM) RM and WM errors in memory impaired 18-month old mice infused with saline (impaired + SAL, n = 8, open triangles) and memory impaired 18-month old mice receiving intra-hippocampal infusions of TAT-Pep5 (impaired + TAT-Pep5, n = 9, closed circles) over four daily sessions of a WRAM task. (C) Representative images indicating the locations of drug infusions at two levels of the hippocampus. ns not significant; * p
    Figure Legend Snippet: Intra-hippocampal infusion of proBDNF impairs memory in well-performing (unimpaired) mice, while TAT-Pep5 infusion improves memory in poorly-performing (impaired) mice. (A) Average (±SEM) RM and WM errors in memory impaired 18-month old mice receiving intra-hippocampal saline infusions (impaired + SAL, n = 8, open triangles) and well-performing 18-month old aged mice receiving uncleavable proBDNF intra-hippocampal infusions (unimpaired + proBDNF, n = 16, open circles) over four daily sessions of a WRAM task. (B) Average (± SEM) RM and WM errors in memory impaired 18-month old mice infused with saline (impaired + SAL, n = 8, open triangles) and memory impaired 18-month old mice receiving intra-hippocampal infusions of TAT-Pep5 (impaired + TAT-Pep5, n = 9, closed circles) over four daily sessions of a WRAM task. (C) Representative images indicating the locations of drug infusions at two levels of the hippocampus. ns not significant; * p

    Techniques Used: Mouse Assay

    Intra-hippocampal infusion of proBDNF increases p-cofilin levels in memory-unimpaired mice to levels seen in memory-impaired mice. (A) p-Cofilin to total cofilin ratio in memory-unimpaired mice, memory-impaired mice, and memory-unimpaired mice infused with proBDNF. (B) Representative p-cofilin and cofilin blots. ** p
    Figure Legend Snippet: Intra-hippocampal infusion of proBDNF increases p-cofilin levels in memory-unimpaired mice to levels seen in memory-impaired mice. (A) p-Cofilin to total cofilin ratio in memory-unimpaired mice, memory-impaired mice, and memory-unimpaired mice infused with proBDNF. (B) Representative p-cofilin and cofilin blots. ** p

    Techniques Used: Mouse Assay

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    Alomone Labs unimpaired probdnf
    Memory impairment in aged mice positively correlates with increases in hippocampal <t>proBDNF</t> levels. (A) Average (±SEM) reference memory (RM) and working memory (WM) errors over four 4-session blocks of a WRAM task in 24-month old aged mice and 4-month old young mice. RM and WM errors positively correlate with proBDNF levels. (B) Increase in proBDNF, but not brain-derived neurotrophic factor (BDNF), in 24-month old aged mice relative to young 4-month old mice. (C) Relative to young 4-month old mice, aged 24-month old mice show increased p75 Neurotrophin Receptor (p75NTR) and decreased p-trk140 and trk140. (D) Relative to young 4-month old mice, aged 24-month old mice show decreased Tissue Plasminogen Activator (tPA), but not carboxypeptidase E (CPE). * p
    Unimpaired Probdnf, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/unimpaired probdnf/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    unimpaired probdnf - by Bioz Stars, 2022-10
    95/100 stars
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    Memory impairment in aged mice positively correlates with increases in hippocampal proBDNF levels. (A) Average (±SEM) reference memory (RM) and working memory (WM) errors over four 4-session blocks of a WRAM task in 24-month old aged mice and 4-month old young mice. RM and WM errors positively correlate with proBDNF levels. (B) Increase in proBDNF, but not brain-derived neurotrophic factor (BDNF), in 24-month old aged mice relative to young 4-month old mice. (C) Relative to young 4-month old mice, aged 24-month old mice show increased p75 Neurotrophin Receptor (p75NTR) and decreased p-trk140 and trk140. (D) Relative to young 4-month old mice, aged 24-month old mice show decreased Tissue Plasminogen Activator (tPA), but not carboxypeptidase E (CPE). * p

    Journal: Frontiers in Aging Neuroscience

    Article Title: Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

    doi: 10.3389/fnagi.2017.00284

    Figure Lengend Snippet: Memory impairment in aged mice positively correlates with increases in hippocampal proBDNF levels. (A) Average (±SEM) reference memory (RM) and working memory (WM) errors over four 4-session blocks of a WRAM task in 24-month old aged mice and 4-month old young mice. RM and WM errors positively correlate with proBDNF levels. (B) Increase in proBDNF, but not brain-derived neurotrophic factor (BDNF), in 24-month old aged mice relative to young 4-month old mice. (C) Relative to young 4-month old mice, aged 24-month old mice show increased p75 Neurotrophin Receptor (p75NTR) and decreased p-trk140 and trk140. (D) Relative to young 4-month old mice, aged 24-month old mice show decreased Tissue Plasminogen Activator (tPA), but not carboxypeptidase E (CPE). * p

    Article Snippet: On d20–22 unimpaired mice in group “unimpaired + proBDNF” were injected with “uncleavable ” mouse proBDNF (proBDNF mut-mouse, Alomone, Jerusalem, Israel) 40 pg/0.4 μL/side.

    Techniques: Mouse Assay, Derivative Assay

    Theoretical model of the role of proBDNF in learning in memory in aged individuals. In young individuals, maturation of proBDNF to BDNF is controlled by plasmin and tPA, and is essential for learning and memory. Aged individuals show decreased levels of tPA and plasmin, and increased levels of uncleaved proBDNF, associated with increased spine remodeling and memory deficits. Blockade of p75NTR (e.g., by TAT-Pep5, as in the current study) leads to spine growth, and rescues learning and memory.

    Journal: Frontiers in Aging Neuroscience

    Article Title: Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

    doi: 10.3389/fnagi.2017.00284

    Figure Lengend Snippet: Theoretical model of the role of proBDNF in learning in memory in aged individuals. In young individuals, maturation of proBDNF to BDNF is controlled by plasmin and tPA, and is essential for learning and memory. Aged individuals show decreased levels of tPA and plasmin, and increased levels of uncleaved proBDNF, associated with increased spine remodeling and memory deficits. Blockade of p75NTR (e.g., by TAT-Pep5, as in the current study) leads to spine growth, and rescues learning and memory.

    Article Snippet: On d20–22 unimpaired mice in group “unimpaired + proBDNF” were injected with “uncleavable ” mouse proBDNF (proBDNF mut-mouse, Alomone, Jerusalem, Israel) 40 pg/0.4 μL/side.

    Techniques:

    Timeline of Experiments 1 and 2. In Experiment 2, mice were split into three groups based on their performance (unimpaired/impaired) and henceforth infused with different drugs (saline, proBDNF, TAT-Pep5). d, day of study; WRAM, behavioral training/testing in the water radial arm maze task; SAL, saline.

    Journal: Frontiers in Aging Neuroscience

    Article Title: Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

    doi: 10.3389/fnagi.2017.00284

    Figure Lengend Snippet: Timeline of Experiments 1 and 2. In Experiment 2, mice were split into three groups based on their performance (unimpaired/impaired) and henceforth infused with different drugs (saline, proBDNF, TAT-Pep5). d, day of study; WRAM, behavioral training/testing in the water radial arm maze task; SAL, saline.

    Article Snippet: On d20–22 unimpaired mice in group “unimpaired + proBDNF” were injected with “uncleavable ” mouse proBDNF (proBDNF mut-mouse, Alomone, Jerusalem, Israel) 40 pg/0.4 μL/side.

    Techniques: Mouse Assay

    Intra-hippocampal infusion of proBDNF impairs memory in well-performing (unimpaired) mice, while TAT-Pep5 infusion improves memory in poorly-performing (impaired) mice. (A) Average (±SEM) RM and WM errors in memory impaired 18-month old mice receiving intra-hippocampal saline infusions (impaired + SAL, n = 8, open triangles) and well-performing 18-month old aged mice receiving uncleavable proBDNF intra-hippocampal infusions (unimpaired + proBDNF, n = 16, open circles) over four daily sessions of a WRAM task. (B) Average (± SEM) RM and WM errors in memory impaired 18-month old mice infused with saline (impaired + SAL, n = 8, open triangles) and memory impaired 18-month old mice receiving intra-hippocampal infusions of TAT-Pep5 (impaired + TAT-Pep5, n = 9, closed circles) over four daily sessions of a WRAM task. (C) Representative images indicating the locations of drug infusions at two levels of the hippocampus. ns not significant; * p

    Journal: Frontiers in Aging Neuroscience

    Article Title: Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

    doi: 10.3389/fnagi.2017.00284

    Figure Lengend Snippet: Intra-hippocampal infusion of proBDNF impairs memory in well-performing (unimpaired) mice, while TAT-Pep5 infusion improves memory in poorly-performing (impaired) mice. (A) Average (±SEM) RM and WM errors in memory impaired 18-month old mice receiving intra-hippocampal saline infusions (impaired + SAL, n = 8, open triangles) and well-performing 18-month old aged mice receiving uncleavable proBDNF intra-hippocampal infusions (unimpaired + proBDNF, n = 16, open circles) over four daily sessions of a WRAM task. (B) Average (± SEM) RM and WM errors in memory impaired 18-month old mice infused with saline (impaired + SAL, n = 8, open triangles) and memory impaired 18-month old mice receiving intra-hippocampal infusions of TAT-Pep5 (impaired + TAT-Pep5, n = 9, closed circles) over four daily sessions of a WRAM task. (C) Representative images indicating the locations of drug infusions at two levels of the hippocampus. ns not significant; * p

    Article Snippet: On d20–22 unimpaired mice in group “unimpaired + proBDNF” were injected with “uncleavable ” mouse proBDNF (proBDNF mut-mouse, Alomone, Jerusalem, Israel) 40 pg/0.4 μL/side.

    Techniques: Mouse Assay

    Intra-hippocampal infusion of proBDNF increases p-cofilin levels in memory-unimpaired mice to levels seen in memory-impaired mice. (A) p-Cofilin to total cofilin ratio in memory-unimpaired mice, memory-impaired mice, and memory-unimpaired mice infused with proBDNF. (B) Representative p-cofilin and cofilin blots. ** p

    Journal: Frontiers in Aging Neuroscience

    Article Title: Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

    doi: 10.3389/fnagi.2017.00284

    Figure Lengend Snippet: Intra-hippocampal infusion of proBDNF increases p-cofilin levels in memory-unimpaired mice to levels seen in memory-impaired mice. (A) p-Cofilin to total cofilin ratio in memory-unimpaired mice, memory-impaired mice, and memory-unimpaired mice infused with proBDNF. (B) Representative p-cofilin and cofilin blots. ** p

    Article Snippet: On d20–22 unimpaired mice in group “unimpaired + proBDNF” were injected with “uncleavable ” mouse proBDNF (proBDNF mut-mouse, Alomone, Jerusalem, Israel) 40 pg/0.4 μL/side.

    Techniques: Mouse Assay