tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: <t>TTA-A2</t> 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tta a2 - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel"

    Article Title: Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

    Journal: Cancer Drug Resistance

    doi: 10.20517/cdr.2021.54

    (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.
    Figure Legend Snippet: (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.

    Techniques Used: Negative Control

    After eight days of the clonogenic assay, colonies were counted (A), and the percent of colonies formed was plotted on a graph (B). Each treatment group reduced the Colony Formation Efficiency of the cells significantly, with the minimum number of colonies in the combination treatment group at 12.7%, compared to the negative control, which had 24.8% of colonies. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.
    Figure Legend Snippet: After eight days of the clonogenic assay, colonies were counted (A), and the percent of colonies formed was plotted on a graph (B). Each treatment group reduced the Colony Formation Efficiency of the cells significantly, with the minimum number of colonies in the combination treatment group at 12.7%, compared to the negative control, which had 24.8% of colonies. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Techniques Used: Clonogenic Assay, Negative Control

    TTA-A2, in combination with PTX, induced increased apoptosis in both monolayer (A, C) and spheroid cultures (B, D) of A549 cells. Cells stained with annexin showed green fluorescence and cells stained with PT showed red fluorescence. In spheroids, several cells showed co-staining with annexin and PI. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. Scale: 100 μm (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.
    Figure Legend Snippet: TTA-A2, in combination with PTX, induced increased apoptosis in both monolayer (A, C) and spheroid cultures (B, D) of A549 cells. Cells stained with annexin showed green fluorescence and cells stained with PT showed red fluorescence. In spheroids, several cells showed co-staining with annexin and PI. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. Scale: 100 μm (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Techniques Used: Staining, Fluorescence, Negative Control

    Compared to the negative control, treatment with TTA-A2 significantly reduced Ca v 3.1 and Ca v 3.2 mRNA expression in all treatment groups. Furthermore, Pgp expression varied non-significantly among the groups (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). Pgp: P-glycoprotein.
    Figure Legend Snippet: Compared to the negative control, treatment with TTA-A2 significantly reduced Ca v 3.1 and Ca v 3.2 mRNA expression in all treatment groups. Furthermore, Pgp expression varied non-significantly among the groups (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). Pgp: P-glycoprotein.

    Techniques Used: Negative Control, Expressing

    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    Effect of systemic administration of THGP on the bladder pain associated with cyclophosphamide (CPA)-induced cystitis. Mice received i.p. administration of CPA at 400 mg/kg, and thereafter, i.p. administration of THGP at 30 and 100 mg/kg or <t>TTA-A2,</t> a T-channel inhibitor, at 1 mg/kg, 3 h after CPA treatment. After the assessment of bladder pain/referred hyperalgesia and of micturition frequency (6 h after i.p. CPA), the bladder was excised from the sacrificed mice to perform bladder weight measurement and Western blotting. (A) Upregulation of cystathionine-γ-lyase (CSE), an H 2 S-forming enzyme, in the mouse bladder 6 h after CPA treatment. The top pictures show the typical photographs of Western blotting, and bottom graphs indicate the quantified data by densitometry. (B) Effects of THGP and TTA-A2 on the bladder pain-like nociceptive behavior observed for 30 min starting 3.5 after i.p. CPA. (C) Effects of THGP and TTA-A2 on the referred hyperalgesia evaluated by von Frey tests 4 h after i.p. CPA. (D) Lack of effects of THGP and TTA-A2 on the increased bladder weight 6 h after i.p. CPA. (E) Lack of effects of THGP and TTA-A2 on the increased micturition frequency for 2 h starting 4 h after i.p. CPA. Typical photographs of visualized voiding spots and the number of voiding spots are shown. Data show the mean with S.E.M. for 5–7 mice. V, vehicle. **P < 0.01, ***P < 0.001 vs. V + V; †P < 0.05, ††P < 0.01 vs. V + CPA.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
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    tta a2 - by Bioz Stars, 2023-02
    86/100 stars

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    1) Product Images from "A hydrolysate of poly- trans -[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Ca v 3.2-dependent pain by sequestering exogenous and endogenous sulfide"

    Article Title: A hydrolysate of poly- trans -[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Ca v 3.2-dependent pain by sequestering exogenous and endogenous sulfide

    Journal: Redox Biology

    doi: 10.1016/j.redox.2022.102579

    Effect of systemic administration of THGP on the bladder pain associated with cyclophosphamide (CPA)-induced cystitis. Mice received i.p. administration of CPA at 400 mg/kg, and thereafter, i.p. administration of THGP at 30 and 100 mg/kg or TTA-A2, a T-channel inhibitor, at 1 mg/kg, 3 h after CPA treatment. After the assessment of bladder pain/referred hyperalgesia and of micturition frequency (6 h after i.p. CPA), the bladder was excised from the sacrificed mice to perform bladder weight measurement and Western blotting. (A) Upregulation of cystathionine-γ-lyase (CSE), an H 2 S-forming enzyme, in the mouse bladder 6 h after CPA treatment. The top pictures show the typical photographs of Western blotting, and bottom graphs indicate the quantified data by densitometry. (B) Effects of THGP and TTA-A2 on the bladder pain-like nociceptive behavior observed for 30 min starting 3.5 after i.p. CPA. (C) Effects of THGP and TTA-A2 on the referred hyperalgesia evaluated by von Frey tests 4 h after i.p. CPA. (D) Lack of effects of THGP and TTA-A2 on the increased bladder weight 6 h after i.p. CPA. (E) Lack of effects of THGP and TTA-A2 on the increased micturition frequency for 2 h starting 4 h after i.p. CPA. Typical photographs of visualized voiding spots and the number of voiding spots are shown. Data show the mean with S.E.M. for 5–7 mice. V, vehicle. **P < 0.01, ***P < 0.001 vs. V + V; †P < 0.05, ††P < 0.01 vs. V + CPA.
    Figure Legend Snippet: Effect of systemic administration of THGP on the bladder pain associated with cyclophosphamide (CPA)-induced cystitis. Mice received i.p. administration of CPA at 400 mg/kg, and thereafter, i.p. administration of THGP at 30 and 100 mg/kg or TTA-A2, a T-channel inhibitor, at 1 mg/kg, 3 h after CPA treatment. After the assessment of bladder pain/referred hyperalgesia and of micturition frequency (6 h after i.p. CPA), the bladder was excised from the sacrificed mice to perform bladder weight measurement and Western blotting. (A) Upregulation of cystathionine-γ-lyase (CSE), an H 2 S-forming enzyme, in the mouse bladder 6 h after CPA treatment. The top pictures show the typical photographs of Western blotting, and bottom graphs indicate the quantified data by densitometry. (B) Effects of THGP and TTA-A2 on the bladder pain-like nociceptive behavior observed for 30 min starting 3.5 after i.p. CPA. (C) Effects of THGP and TTA-A2 on the referred hyperalgesia evaluated by von Frey tests 4 h after i.p. CPA. (D) Lack of effects of THGP and TTA-A2 on the increased bladder weight 6 h after i.p. CPA. (E) Lack of effects of THGP and TTA-A2 on the increased micturition frequency for 2 h starting 4 h after i.p. CPA. Typical photographs of visualized voiding spots and the number of voiding spots are shown. Data show the mean with S.E.M. for 5–7 mice. V, vehicle. **P < 0.01, ***P < 0.001 vs. V + V; †P < 0.05, ††P < 0.01 vs. V + CPA.

    Techniques Used: Western Blot

    Effect of systemic administration of THGP on the pancreatic pain associated with cerulein-induced pancreatitis in mice. Mice received repeated i.p. injection of cerulein at 50 μg/kg at 1-h intervals, 6 times in total. THGP at 100 mg/kg or TTA-A2 at 1 mg/kg was administered i.p. 5 min after the final (6th) cerulein injection, and the referred hyperalgesia was repeatedly evaluated 5.5, 6 and 6.5 h after the onset of repeated cerulein injections (i.e. 0.5, 1 and 1.5 h after the final cerulein injection). Seven hours after the onset of repeated cerulein injections, the blood was withdrawn from the anesthetized mice for the assessment of plasma amylase activity, and the pancreatic tissue was excised from the sacrificed mice afterwards, to perform pancreatic weight measurement and Western blotting. (A) Upregulation of cystathionine-γ-lyase (CSE), an H 2 S-forming enzyme, in the mouse pancreas 7 h after the onset of repeated cerulein injections. The top pictures show the typical photographs of Western blotting, and bottom graphs indicate the quantified data by densitometry. (B) Effects of THGP and TTA-A2 on the referred hyperalgesia evaluated repeatedly by von Frey test 5.5–6.5 h after the onset of repeated cerulein injections. (C, D) Lack of effect of THGP and TTA-A2 on the increased pancreatic weight (C) and plasma amylase activity (D) in cerulein-treated mice. V, vehicle. Data show the mean with S.E.M. from 9 mice. **P < 0.01, ***P < 0.001 vs. V + V; †P < 0.05, ††P < 0.01 vs. V + cerulein.
    Figure Legend Snippet: Effect of systemic administration of THGP on the pancreatic pain associated with cerulein-induced pancreatitis in mice. Mice received repeated i.p. injection of cerulein at 50 μg/kg at 1-h intervals, 6 times in total. THGP at 100 mg/kg or TTA-A2 at 1 mg/kg was administered i.p. 5 min after the final (6th) cerulein injection, and the referred hyperalgesia was repeatedly evaluated 5.5, 6 and 6.5 h after the onset of repeated cerulein injections (i.e. 0.5, 1 and 1.5 h after the final cerulein injection). Seven hours after the onset of repeated cerulein injections, the blood was withdrawn from the anesthetized mice for the assessment of plasma amylase activity, and the pancreatic tissue was excised from the sacrificed mice afterwards, to perform pancreatic weight measurement and Western blotting. (A) Upregulation of cystathionine-γ-lyase (CSE), an H 2 S-forming enzyme, in the mouse pancreas 7 h after the onset of repeated cerulein injections. The top pictures show the typical photographs of Western blotting, and bottom graphs indicate the quantified data by densitometry. (B) Effects of THGP and TTA-A2 on the referred hyperalgesia evaluated repeatedly by von Frey test 5.5–6.5 h after the onset of repeated cerulein injections. (C, D) Lack of effect of THGP and TTA-A2 on the increased pancreatic weight (C) and plasma amylase activity (D) in cerulein-treated mice. V, vehicle. Data show the mean with S.E.M. from 9 mice. **P < 0.01, ***P < 0.001 vs. V + V; †P < 0.05, ††P < 0.01 vs. V + cerulein.

    Techniques Used: Injection, Activity Assay, Western Blot

    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: <t>TTA-A2</t> 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tta a2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tta a2 - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel"

    Article Title: Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

    Journal: Cancer Drug Resistance

    doi: 10.20517/cdr.2021.54

    (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.
    Figure Legend Snippet: (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.

    Techniques Used: Negative Control

    After eight days of the clonogenic assay, colonies were counted (A), and the percent of colonies formed was plotted on a graph (B). Each treatment group reduced the Colony Formation Efficiency of the cells significantly, with the minimum number of colonies in the combination treatment group at 12.7%, compared to the negative control, which had 24.8% of colonies. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.
    Figure Legend Snippet: After eight days of the clonogenic assay, colonies were counted (A), and the percent of colonies formed was plotted on a graph (B). Each treatment group reduced the Colony Formation Efficiency of the cells significantly, with the minimum number of colonies in the combination treatment group at 12.7%, compared to the negative control, which had 24.8% of colonies. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Techniques Used: Clonogenic Assay, Negative Control

    TTA-A2, in combination with PTX, induced increased apoptosis in both monolayer (A, C) and spheroid cultures (B, D) of A549 cells. Cells stained with annexin showed green fluorescence and cells stained with PT showed red fluorescence. In spheroids, several cells showed co-staining with annexin and PI. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. Scale: 100 μm (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.
    Figure Legend Snippet: TTA-A2, in combination with PTX, induced increased apoptosis in both monolayer (A, C) and spheroid cultures (B, D) of A549 cells. Cells stained with annexin showed green fluorescence and cells stained with PT showed red fluorescence. In spheroids, several cells showed co-staining with annexin and PI. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. Scale: 100 μm (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Techniques Used: Staining, Fluorescence, Negative Control

    Compared to the negative control, treatment with TTA-A2 significantly reduced Ca v 3.1 and Ca v 3.2 mRNA expression in all treatment groups. Furthermore, Pgp expression varied non-significantly among the groups (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). Pgp: P-glycoprotein.
    Figure Legend Snippet: Compared to the negative control, treatment with TTA-A2 significantly reduced Ca v 3.1 and Ca v 3.2 mRNA expression in all treatment groups. Furthermore, Pgp expression varied non-significantly among the groups (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). Pgp: P-glycoprotein.

    Techniques Used: Negative Control, Expressing

    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 1 article reviews
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    tta a2 - by Bioz Stars, 2023-02
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    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tta a2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tta a2 - by Bioz Stars, 2023-02
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    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    A and B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color coded and plotted under control A and in the presence of <t>TTA-A2</t> (10 μM) ( B ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ -firing sites was reduced by TTA-A2 G ( n = 7). H and I Active firing sites were individually color coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) ( I ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ -firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = p<0.01,**** = p<0.0001. All data graphed as mean ± SEM.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tta a2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tta a2 - by Bioz Stars, 2023-02
    94/100 stars

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    1) Product Images from "Ca 2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon"

    Article Title: Ca 2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Journal: eLife

    doi: 10.7554/eLife.64099

    A and B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color coded and plotted under control A and in the presence of TTA-A2 (10 μM) ( B ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ -firing sites was reduced by TTA-A2 G ( n = 7). H and I Active firing sites were individually color coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) ( I ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ -firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = p<0.01,**** = p<0.0001. All data graphed as mean ± SEM.
    Figure Legend Snippet: A and B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color coded and plotted under control A and in the presence of TTA-A2 (10 μM) ( B ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ -firing sites was reduced by TTA-A2 G ( n = 7). H and I Active firing sites were individually color coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) ( I ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ -firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = p<0.01,**** = p<0.0001. All data graphed as mean ± SEM.

    Techniques Used: Activity Assay


    Figure Legend Snippet:

    Techniques Used: Sequencing, Software

    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    A and B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color coded and plotted under control A and in the presence of <t>TTA-A2</t> (10 μM) ( B ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ -firing sites was reduced by TTA-A2 G ( n = 7). H and I Active firing sites were individually color coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) ( I ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ -firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = p<0.01,**** = p<0.0001. All data graphed as mean ± SEM.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Ca 2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon"

    Article Title: Ca 2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Journal: eLife

    doi: 10.7554/eLife.64099

    A and B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color coded and plotted under control A and in the presence of TTA-A2 (10 μM) ( B ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ -firing sites was reduced by TTA-A2 G ( n = 7). H and I Active firing sites were individually color coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) ( I ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ -firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = p<0.01,**** = p<0.0001. All data graphed as mean ± SEM.
    Figure Legend Snippet: A and B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color coded and plotted under control A and in the presence of TTA-A2 (10 μM) ( B ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ -firing sites was reduced by TTA-A2 G ( n = 7). H and I Active firing sites were individually color coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) ( I ) conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ -firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = p<0.01,**** = p<0.0001. All data graphed as mean ± SEM.

    Techniques Used: Activity Assay


    Figure Legend Snippet:

    Techniques Used: Sequencing, Software

    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    A&B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color-coded and plotted under control A and in the presence of <t>TTA-A2</t> (10 μM) B conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ firing sites was reduced by TTA-A2 G ( n = 7). H&I Active firing sites were individually color-coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) I conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = P <0.01,**** = P <0.0001. All data graphed as mean ± SEM.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tta a2/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
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    1) Product Images from "Ca 2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the colon"

    Article Title: Ca 2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the colon

    Journal: bioRxiv

    doi: 10.1101/2020.10.26.355404

    A&B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color-coded and plotted under control A and in the presence of TTA-A2 (10 μM) B conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ firing sites was reduced by TTA-A2 G ( n = 7). H&I Active firing sites were individually color-coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) I conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = P <0.01,**** = P <0.0001. All data graphed as mean ± SEM.
    Figure Legend Snippet: A&B Occurrence maps showing ICC-SM network active firing sites. Sites were individually color-coded and plotted under control A and in the presence of TTA-A2 (10 μM) B conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of TTA-A2 showing PTCL area (blue) and PTCL count (green) under control conditions C and in the presence of TTA-A2 D . Summary graphs of average percentage change of PTCL area E , PTCL count F and the number of Ca 2+ firing sites was reduced by TTA-A2 G ( n = 7). H&I Active firing sites were individually color-coded and plotted as an occurrence maps in the ICC-SM network under control H and Z-944 (1 μM) I conditions. Plots of Ca 2+ transient particle activity of ICC-SM in control conditions and in the presence of Z-944 showing PTCL area (blue) and PTCL count (green) under control conditions J and in the presence of Z-944 K . Summary graphs of average percentage change of PTCL area L , PTCL count M and the number of Ca 2+ firing sites was reduced by Z-944 N ( n = 5). Significance determined using unpaired t-test, ** = P <0.01,**** = P <0.0001. All data graphed as mean ± SEM.

    Techniques Used: Activity Assay

    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    tta a2  (Alomone Labs)


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    Alomone Labs tta a2
    Effect of T-type Ca 2+ channel blockers and genetic deletion of Ca v 3.2 on CPA-induced bladder pain-like nociceptive behavior ( A , D , G , J ), referred hyperalgesia ( B , E , H , K ) and bladder swelling ( C , F , I , L ) in mice. ( A – F ) In ddY mice, 6-prenylnaringenin (6-PNG), a hop-derived T-type Ca 2+ channel blocker, or KTt-45, a derivative of 6-PNG, at 10 and 30 mg/kg was administered i.p. 3 h 15 min after i.p. CPA at 400 mg/kg. ( G – I ) In C57BL/6 mice, <t>TTA-A2</t> at 1 mg/kg was administered i.p. 3 h after the CPA treatment. ( J – L ) CPA at 400 mg/kg was administered i.p. to wild-type (WT) and Ca v 3.2-knockout mice (KO) of a C57BL/6J background. Nociceptive behaviors were counted for 30 min starting 3.5 h after CPA treatment, followed immediately by evaluation of referred hyperalgesia/allodynia and then measurement of wet tissue weight of the excised bladder. V, vehicle. Data show the mean with S.E.M. for 6–8 (A–C), 5 (D–F), 5–6 (G–I) or 6 (J–L) mice. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. V + V or V in WT. † p < 0.05, †† p < 0.01 vs. V + CPA or CPA in WT.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H 2 S/Ca v 3.2 Signaling in Mice"

    Article Title: Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H 2 S/Ca v 3.2 Signaling in Mice

    Journal: Cells

    doi: 10.3390/cells9081748

    Effect of T-type Ca 2+ channel blockers and genetic deletion of Ca v 3.2 on CPA-induced bladder pain-like nociceptive behavior ( A , D , G , J ), referred hyperalgesia ( B , E , H , K ) and bladder swelling ( C , F , I , L ) in mice. ( A – F ) In ddY mice, 6-prenylnaringenin (6-PNG), a hop-derived T-type Ca 2+ channel blocker, or KTt-45, a derivative of 6-PNG, at 10 and 30 mg/kg was administered i.p. 3 h 15 min after i.p. CPA at 400 mg/kg. ( G – I ) In C57BL/6 mice, TTA-A2 at 1 mg/kg was administered i.p. 3 h after the CPA treatment. ( J – L ) CPA at 400 mg/kg was administered i.p. to wild-type (WT) and Ca v 3.2-knockout mice (KO) of a C57BL/6J background. Nociceptive behaviors were counted for 30 min starting 3.5 h after CPA treatment, followed immediately by evaluation of referred hyperalgesia/allodynia and then measurement of wet tissue weight of the excised bladder. V, vehicle. Data show the mean with S.E.M. for 6–8 (A–C), 5 (D–F), 5–6 (G–I) or 6 (J–L) mice. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. V + V or V in WT. † p < 0.05, †† p < 0.01 vs. V + CPA or CPA in WT.
    Figure Legend Snippet: Effect of T-type Ca 2+ channel blockers and genetic deletion of Ca v 3.2 on CPA-induced bladder pain-like nociceptive behavior ( A , D , G , J ), referred hyperalgesia ( B , E , H , K ) and bladder swelling ( C , F , I , L ) in mice. ( A – F ) In ddY mice, 6-prenylnaringenin (6-PNG), a hop-derived T-type Ca 2+ channel blocker, or KTt-45, a derivative of 6-PNG, at 10 and 30 mg/kg was administered i.p. 3 h 15 min after i.p. CPA at 400 mg/kg. ( G – I ) In C57BL/6 mice, TTA-A2 at 1 mg/kg was administered i.p. 3 h after the CPA treatment. ( J – L ) CPA at 400 mg/kg was administered i.p. to wild-type (WT) and Ca v 3.2-knockout mice (KO) of a C57BL/6J background. Nociceptive behaviors were counted for 30 min starting 3.5 h after CPA treatment, followed immediately by evaluation of referred hyperalgesia/allodynia and then measurement of wet tissue weight of the excised bladder. V, vehicle. Data show the mean with S.E.M. for 6–8 (A–C), 5 (D–F), 5–6 (G–I) or 6 (J–L) mice. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. V + V or V in WT. † p < 0.05, †† p < 0.01 vs. V + CPA or CPA in WT.

    Techniques Used: Derivative Assay, Knock-Out

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    Alomone Labs tta a2
    (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: <t>TTA-A2</t> 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.
    Tta A2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.

    Journal: Cancer Drug Resistance

    Article Title: Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

    doi: 10.20517/cdr.2021.54

    Figure Lengend Snippet: (A) In the monolayer culture, a change in cell morphology was observed in the treatment groups (Groups II-V). Treated cells showed decreased cell density and changed morphology from epithelial form to an elongated or circular shape (solid black cells). (B) In the spheroid culture, all the spheroids had a comparable size of ~300 μm, indicating no treatment effect on reducing the spheroid size, regardless of treatment. Scale bar: 200 μm. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. PTX: Paclitaxel.

    Article Snippet: PTX and TTA-A2 (Alomone Labs, Jerusalem, Israel) were used as the anticancer drug and the TTCC blocker, respectively.

    Techniques: Negative Control

    After eight days of the clonogenic assay, colonies were counted (A), and the percent of colonies formed was plotted on a graph (B). Each treatment group reduced the Colony Formation Efficiency of the cells significantly, with the minimum number of colonies in the combination treatment group at 12.7%, compared to the negative control, which had 24.8% of colonies. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Journal: Cancer Drug Resistance

    Article Title: Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

    doi: 10.20517/cdr.2021.54

    Figure Lengend Snippet: After eight days of the clonogenic assay, colonies were counted (A), and the percent of colonies formed was plotted on a graph (B). Each treatment group reduced the Colony Formation Efficiency of the cells significantly, with the minimum number of colonies in the combination treatment group at 12.7%, compared to the negative control, which had 24.8% of colonies. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Article Snippet: PTX and TTA-A2 (Alomone Labs, Jerusalem, Israel) were used as the anticancer drug and the TTCC blocker, respectively.

    Techniques: Clonogenic Assay, Negative Control

    TTA-A2, in combination with PTX, induced increased apoptosis in both monolayer (A, C) and spheroid cultures (B, D) of A549 cells. Cells stained with annexin showed green fluorescence and cells stained with PT showed red fluorescence. In spheroids, several cells showed co-staining with annexin and PI. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. Scale: 100 μm (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Journal: Cancer Drug Resistance

    Article Title: Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

    doi: 10.20517/cdr.2021.54

    Figure Lengend Snippet: TTA-A2, in combination with PTX, induced increased apoptosis in both monolayer (A, C) and spheroid cultures (B, D) of A549 cells. Cells stained with annexin showed green fluorescence and cells stained with PT showed red fluorescence. In spheroids, several cells showed co-staining with annexin and PI. I: negative control; II: PTX 10 nM; III: TTA-A2 50 nM; IV: TTA-A2 100 nM; V: PTX 10 nM + TTA-A2 100 nM. Scale: 100 μm (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). PTX: Paclitaxel.

    Article Snippet: PTX and TTA-A2 (Alomone Labs, Jerusalem, Israel) were used as the anticancer drug and the TTCC blocker, respectively.

    Techniques: Staining, Fluorescence, Negative Control

    Compared to the negative control, treatment with TTA-A2 significantly reduced Ca v 3.1 and Ca v 3.2 mRNA expression in all treatment groups. Furthermore, Pgp expression varied non-significantly among the groups (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). Pgp: P-glycoprotein.

    Journal: Cancer Drug Resistance

    Article Title: Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

    doi: 10.20517/cdr.2021.54

    Figure Lengend Snippet: Compared to the negative control, treatment with TTA-A2 significantly reduced Ca v 3.1 and Ca v 3.2 mRNA expression in all treatment groups. Furthermore, Pgp expression varied non-significantly among the groups (non-significant P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001). Pgp: P-glycoprotein.

    Article Snippet: PTX and TTA-A2 (Alomone Labs, Jerusalem, Israel) were used as the anticancer drug and the TTCC blocker, respectively.

    Techniques: Negative Control, Expressing