trpv4 blocking peptide  (Alomone Labs)


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    Alomone Labs trpv4 blocking peptide
    <t>TRPV4</t> activation led to enhanced expression of TNF receptor 1 (TNFR1). A Immunoblotting analysis showing that pre-injection of GSK101 enhanced the expression of TNFR1 in the retina, compared with the control group. B Bar chart summarizing mean expression levels of TNFR1 under different conditions. n = 5, p
    Trpv4 Blocking Peptide, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trpv4 blocking peptide/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trpv4 blocking peptide - by Bioz Stars, 2022-08
    94/100 stars

    Images

    1) Product Images from "TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway"

    Article Title: TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

    Journal: Journal of Neuroinflammation

    doi: 10.1186/s12974-021-02315-8

    TRPV4 activation led to enhanced expression of TNF receptor 1 (TNFR1). A Immunoblotting analysis showing that pre-injection of GSK101 enhanced the expression of TNFR1 in the retina, compared with the control group. B Bar chart summarizing mean expression levels of TNFR1 under different conditions. n = 5, p
    Figure Legend Snippet: TRPV4 activation led to enhanced expression of TNF receptor 1 (TNFR1). A Immunoblotting analysis showing that pre-injection of GSK101 enhanced the expression of TNFR1 in the retina, compared with the control group. B Bar chart summarizing mean expression levels of TNFR1 under different conditions. n = 5, p

    Techniques Used: Activation Assay, Expressing, Injection

    TRPV4 activation led to increased phosphorylation of JAK2 and STAT3, thereby inducing NF-κB p65 translocation from the cytoplasm into the nucleus. A , C Immunoblotting analysis showing that GSK101 treatment increased the phosphorylation of STAT3 and JAK2, compared with the control group, but had no effect on the protein levels of JAK2 and STAT3 ( C ). B , D Bar charts summarizing mean expression levels of phosphorylated STAT3/STAT ( B ) and phosphorylated JAK2/JAK2 ( D ) under different conditions. n = 3 for all groups, * p
    Figure Legend Snippet: TRPV4 activation led to increased phosphorylation of JAK2 and STAT3, thereby inducing NF-κB p65 translocation from the cytoplasm into the nucleus. A , C Immunoblotting analysis showing that GSK101 treatment increased the phosphorylation of STAT3 and JAK2, compared with the control group, but had no effect on the protein levels of JAK2 and STAT3 ( C ). B , D Bar charts summarizing mean expression levels of phosphorylated STAT3/STAT ( B ) and phosphorylated JAK2/JAK2 ( D ) under different conditions. n = 3 for all groups, * p

    Techniques Used: Activation Assay, Translocation Assay, Expressing

    Müller cells express functional TRPV4. A Immunofluorescence images show that cells with red autofluorescence are Müller cells. A1 Immunofluorescence images show cells with red autofluorescence in rat retinal vertical slices acquired from TdTomato transgenic mouse retina (Tomato). A2 Immunofluorescence images show glutamine synthetase (GS) protein staining (green) in the slices depicted in A1 . A3 Immunofluorescence images show DAPI (blue) staining in the slices depicted in A1 . A4 shows merged images. Scale bar: 50 µm. B Representative trace recorded from a Müller cell identified by spontaneous red fluorescence, showing that perfusion with GSK101 (10 μM) caused significant depolarization of Müller membrane potential. C Bar chart showing GSK101-induced depolarization of Müller cell membrane potential. n = 4. * p
    Figure Legend Snippet: Müller cells express functional TRPV4. A Immunofluorescence images show that cells with red autofluorescence are Müller cells. A1 Immunofluorescence images show cells with red autofluorescence in rat retinal vertical slices acquired from TdTomato transgenic mouse retina (Tomato). A2 Immunofluorescence images show glutamine synthetase (GS) protein staining (green) in the slices depicted in A1 . A3 Immunofluorescence images show DAPI (blue) staining in the slices depicted in A1 . A4 shows merged images. Scale bar: 50 µm. B Representative trace recorded from a Müller cell identified by spontaneous red fluorescence, showing that perfusion with GSK101 (10 μM) caused significant depolarization of Müller membrane potential. C Bar chart showing GSK101-induced depolarization of Müller cell membrane potential. n = 4. * p

    Techniques Used: Functional Assay, Immunofluorescence, Transgenic Assay, Staining, Fluorescence

    TRPV4 activation enhances TNF-α production in retinal tissues. A Cumulative changes in TNF-α mRNA levels in saline-injected retinas (control) and retinas with GSK101 injection at 1 week. n = 5, * p
    Figure Legend Snippet: TRPV4 activation enhances TNF-α production in retinal tissues. A Cumulative changes in TNF-α mRNA levels in saline-injected retinas (control) and retinas with GSK101 injection at 1 week. n = 5, * p

    Techniques Used: Activation Assay, Injection

    TRPV4 activation enhances the expression of GFAP. A Immunofluorescence images show GFAP protein expression profiles in rat retinal vertical slices acquired from sham-operated retinas (saline-injected; control) ( A1 ), 1 µM GSK101-injected retinas ( A2 ), and 10 µM GSK101-injected retinas ( A3 ). Retinas that received no GFAP antibody served as negative controls ( A4 ). Double immunofluorescence staining showing GFAP expression when the GFAP antibody was pre-adsorbed with its blocking peptide (BP) ( A5 ). Scale bar: 20 µm. B Representative immunoblots showing changes in GFAP protein levels in control and 10 µM GSK101-injected retinas. C Bar chart summarizing mean expression levels of GFAP under different conditions. n = 6. * p
    Figure Legend Snippet: TRPV4 activation enhances the expression of GFAP. A Immunofluorescence images show GFAP protein expression profiles in rat retinal vertical slices acquired from sham-operated retinas (saline-injected; control) ( A1 ), 1 µM GSK101-injected retinas ( A2 ), and 10 µM GSK101-injected retinas ( A3 ). Retinas that received no GFAP antibody served as negative controls ( A4 ). Double immunofluorescence staining showing GFAP expression when the GFAP antibody was pre-adsorbed with its blocking peptide (BP) ( A5 ). Scale bar: 20 µm. B Representative immunoblots showing changes in GFAP protein levels in control and 10 µM GSK101-injected retinas. C Bar chart summarizing mean expression levels of GFAP under different conditions. n = 6. * p

    Techniques Used: Activation Assay, Expressing, Immunofluorescence, Injection, Double Immunofluorescence Staining, Blocking Assay, Western Blot

    TNF-α inhibition reduces TRPV4-mediated retinal cell apoptosis. A1 – A2 DAPI staining in GSK101-injected ( A1 ) and R7050 with GSK101-injected (R7050 + GSK101) ( A2 ) whole flat-mounted retinas at 7 days after injections in the regions at angle 0°. A3 – A4 Counterstained images with TUNEL staining detection of cell apoptosis (green). A5 – A6 Merged images of corresponding TUNEL and DAPI images. Scale bar, 50 µm (for all images). B Bar chart summarizing mean numbers of TUNEL-positive cells in each retina under different conditions. R7050 (1 µM, 2 μl) was pre-injected 1 day before the GSK101 injection. n = 5. ** p
    Figure Legend Snippet: TNF-α inhibition reduces TRPV4-mediated retinal cell apoptosis. A1 – A2 DAPI staining in GSK101-injected ( A1 ) and R7050 with GSK101-injected (R7050 + GSK101) ( A2 ) whole flat-mounted retinas at 7 days after injections in the regions at angle 0°. A3 – A4 Counterstained images with TUNEL staining detection of cell apoptosis (green). A5 – A6 Merged images of corresponding TUNEL and DAPI images. Scale bar, 50 µm (for all images). B Bar chart summarizing mean numbers of TUNEL-positive cells in each retina under different conditions. R7050 (1 µM, 2 μl) was pre-injected 1 day before the GSK101 injection. n = 5. ** p

    Techniques Used: Inhibition, Staining, Injection, TUNEL Assay

    TRPV4 activation enhances TNF-α production in cultured Müller cells. A Morphology of cultured Müller cells. Scale bar: 50 µm. B GSK101 treatment enhanced GFAP protein levels in cultured Müller cells. n = 4. ** p
    Figure Legend Snippet: TRPV4 activation enhances TNF-α production in cultured Müller cells. A Morphology of cultured Müller cells. Scale bar: 50 µm. B GSK101 treatment enhanced GFAP protein levels in cultured Müller cells. n = 4. ** p

    Techniques Used: Activation Assay, Cell Culture

    Changes in TRPV4 protein levels in retinas of rats with COH. A Representative immunoblots showing changes in TRPV4 protein levels in control and COH retinal extracts at different postoperative times (G1w, G2w, and G3w). B Bar chart summarizing mean expression levels of TRPV4 at different postoperative times. Data are presented as means ± standard errors of the mean. n = 7, 4, 6, and 5, respectively. ** p
    Figure Legend Snippet: Changes in TRPV4 protein levels in retinas of rats with COH. A Representative immunoblots showing changes in TRPV4 protein levels in control and COH retinal extracts at different postoperative times (G1w, G2w, and G3w). B Bar chart summarizing mean expression levels of TRPV4 at different postoperative times. Data are presented as means ± standard errors of the mean. n = 7, 4, 6, and 5, respectively. ** p

    Techniques Used: Western Blot, Expressing

    Schematic diagram showing the signaling pathway involved in TRPV4 activation-mediated TNF-α production in Müller cells and RGC apoptosis in COH retinas. NF-κB nuclear factor-kappa B, TNF-α tumor necrosis factor-α, TNFR1 TNF receptor 1
    Figure Legend Snippet: Schematic diagram showing the signaling pathway involved in TRPV4 activation-mediated TNF-α production in Müller cells and RGC apoptosis in COH retinas. NF-κB nuclear factor-kappa B, TNF-α tumor necrosis factor-α, TNFR1 TNF receptor 1

    Techniques Used: Activation Assay

    Effects of GSK101 on retinal ganglion cell (RGC) apoptosis and survival. A TRPV4 activation leads to enhanced RGC apoptosis. A1 – A3 4′,6-diamidino-2-phenylindole (DAPI) staining in saline-injected (control) ( A1 ), GSK101-injected (GSK101) ( A2 ), and HC-067 with GSK101 (HC) ( A3 ) retinas at 1 week after injection in the regions at angle 0°. Images were acquired from whole flat-mounted retinal preparations. A4 – A6 , Counterstained images with TUNEL staining detection of RGC apoptosis (green). A7 – A9 , Merged images of corresponding TUNEL and DAPI images. Scale bar: 50 µm. B Bar chart summarizing mean numbers of TUNEL-positive cells in each retina under different conditions. n = 5 for all groups. C Pre-application of HC-067 reduces RGC apoptosis in COH retinas. C1 – C3 DAPI staining in sham-operated (control) ( C1 ), COH ( C2 ), and HC-067 with COH (HC + COH) ( C3 ) retinas at G2w. C4 – C6 Counterstained images with TUNEL staining detection of RGC apoptosis (green). C7 – C9 Merged images of corresponding TUNEL and DAPI images. Scale bar, 50 μm. D Bar chart summarizing mean numbers of TUNEL-positive cells in each retina under different conditions. n = 6 for all groups. * p
    Figure Legend Snippet: Effects of GSK101 on retinal ganglion cell (RGC) apoptosis and survival. A TRPV4 activation leads to enhanced RGC apoptosis. A1 – A3 4′,6-diamidino-2-phenylindole (DAPI) staining in saline-injected (control) ( A1 ), GSK101-injected (GSK101) ( A2 ), and HC-067 with GSK101 (HC) ( A3 ) retinas at 1 week after injection in the regions at angle 0°. Images were acquired from whole flat-mounted retinal preparations. A4 – A6 , Counterstained images with TUNEL staining detection of RGC apoptosis (green). A7 – A9 , Merged images of corresponding TUNEL and DAPI images. Scale bar: 50 µm. B Bar chart summarizing mean numbers of TUNEL-positive cells in each retina under different conditions. n = 5 for all groups. C Pre-application of HC-067 reduces RGC apoptosis in COH retinas. C1 – C3 DAPI staining in sham-operated (control) ( C1 ), COH ( C2 ), and HC-067 with COH (HC + COH) ( C3 ) retinas at G2w. C4 – C6 Counterstained images with TUNEL staining detection of RGC apoptosis (green). C7 – C9 Merged images of corresponding TUNEL and DAPI images. Scale bar, 50 μm. D Bar chart summarizing mean numbers of TUNEL-positive cells in each retina under different conditions. n = 6 for all groups. * p

    Techniques Used: Activation Assay, Staining, Injection, TUNEL Assay

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    Alomone Labs trpv4
    FD20 content in serum. In Ctrl and DU groups, after treatment with <t>TRPV4</t> agonist GSK1016790 A or inhibitor HC067047, the content of FD20 in serum was detected. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P
    Trpv4, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trpv4/product/Alomone Labs
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    trpv4 - by Bioz Stars, 2022-08
    95/100 stars
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    FD20 content in serum. In Ctrl and DU groups, after treatment with TRPV4 agonist GSK1016790 A or inhibitor HC067047, the content of FD20 in serum was detected. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P

    Journal: BioMed Research International

    Article Title: Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers

    doi: 10.1155/2022/2777882

    Figure Lengend Snippet: FD20 content in serum. In Ctrl and DU groups, after treatment with TRPV4 agonist GSK1016790 A or inhibitor HC067047, the content of FD20 in serum was detected. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P

    Article Snippet: The major findings of this study are as follows: (1) the expression of TRPV4 was significantly increased in children with duodenal ulcer and had good diagnostic value in children with duodenal ulcer. (2) TRPV4 expression increased and calcium influx also increased in duodenal ulcer mice. (3) TRPV4 can promote intestinal epithelial permeability in mice with duodenal ulcer. (4) Intestinal permeability mediated by TRPV4 can affect the entry of cytokines into the blood and exacerbate the progression of ulcers.

    Techniques:

    The content of inflammatory factor TNF- α in tissues and serum. (a) In the Ctrl and DU groups, serum TNF- α content changes after treatment with TRPV4 agonists GSK1016790 A or inhibitor HC067047. (b) In the Ctrl and DU groups, duodenal tissue TNF- α content changes after treatment with TRPV4 agonists GSK1016790 A or inhibitor HC067047. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P

    Journal: BioMed Research International

    Article Title: Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers

    doi: 10.1155/2022/2777882

    Figure Lengend Snippet: The content of inflammatory factor TNF- α in tissues and serum. (a) In the Ctrl and DU groups, serum TNF- α content changes after treatment with TRPV4 agonists GSK1016790 A or inhibitor HC067047. (b) In the Ctrl and DU groups, duodenal tissue TNF- α content changes after treatment with TRPV4 agonists GSK1016790 A or inhibitor HC067047. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P

    Article Snippet: The major findings of this study are as follows: (1) the expression of TRPV4 was significantly increased in children with duodenal ulcer and had good diagnostic value in children with duodenal ulcer. (2) TRPV4 expression increased and calcium influx also increased in duodenal ulcer mice. (3) TRPV4 can promote intestinal epithelial permeability in mice with duodenal ulcer. (4) Intestinal permeability mediated by TRPV4 can affect the entry of cytokines into the blood and exacerbate the progression of ulcers.

    Techniques:

    TRPV4 is highly expressed in children with duodenal ulcer and has good diagnostic value. (a) and (b) Immunohistochemistry representative images (a) and summary (b) data showing the expression of TRPV4 in children with duodenal ulcer; Ctrl: nonduodenal ulcer; DU: duodenal ulcer. (c) ROC curve analyses of TRPV4. n = 11, ∗ P

    Journal: BioMed Research International

    Article Title: Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers

    doi: 10.1155/2022/2777882

    Figure Lengend Snippet: TRPV4 is highly expressed in children with duodenal ulcer and has good diagnostic value. (a) and (b) Immunohistochemistry representative images (a) and summary (b) data showing the expression of TRPV4 in children with duodenal ulcer; Ctrl: nonduodenal ulcer; DU: duodenal ulcer. (c) ROC curve analyses of TRPV4. n = 11, ∗ P

    Article Snippet: The major findings of this study are as follows: (1) the expression of TRPV4 was significantly increased in children with duodenal ulcer and had good diagnostic value in children with duodenal ulcer. (2) TRPV4 expression increased and calcium influx also increased in duodenal ulcer mice. (3) TRPV4 can promote intestinal epithelial permeability in mice with duodenal ulcer. (4) Intestinal permeability mediated by TRPV4 can affect the entry of cytokines into the blood and exacerbate the progression of ulcers.

    Techniques: Diagnostic Assay, Immunohistochemistry, Expressing

    Increased TRPV4 expression and enhanced calcium influx in duodenal ulcer mice. (a) Representative images showing hematoxylin-eosin staining of duodenum tissue. (b) and (c) Representative images (b) and summary (c) data showing the expression of TRPV4 in duodenal ulcer mice. (d) and (e) Representative traces (d) and summarized data (e) showing the changes in the intracellular Ca 2+ concentration of duodenal tissue between DU and Ctrl group. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P

    Journal: BioMed Research International

    Article Title: Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers

    doi: 10.1155/2022/2777882

    Figure Lengend Snippet: Increased TRPV4 expression and enhanced calcium influx in duodenal ulcer mice. (a) Representative images showing hematoxylin-eosin staining of duodenum tissue. (b) and (c) Representative images (b) and summary (c) data showing the expression of TRPV4 in duodenal ulcer mice. (d) and (e) Representative traces (d) and summarized data (e) showing the changes in the intracellular Ca 2+ concentration of duodenal tissue between DU and Ctrl group. Ctrl: nonduodenal ulcer; DU: duodenal ulcer. n = 3, ∗ P

    Article Snippet: The major findings of this study are as follows: (1) the expression of TRPV4 was significantly increased in children with duodenal ulcer and had good diagnostic value in children with duodenal ulcer. (2) TRPV4 expression increased and calcium influx also increased in duodenal ulcer mice. (3) TRPV4 can promote intestinal epithelial permeability in mice with duodenal ulcer. (4) Intestinal permeability mediated by TRPV4 can affect the entry of cytokines into the blood and exacerbate the progression of ulcers.

    Techniques: Expressing, Mouse Assay, Staining, Concentration Assay

    Expression and regulation of TRPV4 in the kidney, DRG, and MA

    Journal: Hypertension

    Article Title: Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism

    doi: 10.1161/HYPERTENSIONAHA.109.147710

    Figure Lengend Snippet: Expression and regulation of TRPV4 in the kidney, DRG, and MA

    Article Snippet: These results indicate that blockade of 4α-PDD-induced hypotension by RuR is mainly mediated by antagonizing TRPV4 instead of TRPV1, a result consistent with previous reports.

    Techniques: Expressing

    Responses of MAP to bolus administration of 4α-PDD (2.5 mg/kg, iv) with or without TRPV4 blockade (RuR, 3 mg/kg, iv) in conscious DR or DS rats. A∼D, time course responses of MAP to bolus administration of 4α-PDD with or without

    Journal: Hypertension

    Article Title: Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism

    doi: 10.1161/HYPERTENSIONAHA.109.147710

    Figure Lengend Snippet: Responses of MAP to bolus administration of 4α-PDD (2.5 mg/kg, iv) with or without TRPV4 blockade (RuR, 3 mg/kg, iv) in conscious DR or DS rats. A∼D, time course responses of MAP to bolus administration of 4α-PDD with or without

    Article Snippet: These results indicate that blockade of 4α-PDD-induced hypotension by RuR is mainly mediated by antagonizing TRPV4 instead of TRPV1, a result consistent with previous reports.

    Techniques:

    Western blot analysis of protein expression of TRPV4 in DRG and MA of DR or DS rats. Values are mean ± SE (n=4∼5). *P

    Journal: Hypertension

    Article Title: Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism

    doi: 10.1161/HYPERTENSIONAHA.109.147710

    Figure Lengend Snippet: Western blot analysis of protein expression of TRPV4 in DRG and MA of DR or DS rats. Values are mean ± SE (n=4∼5). *P

    Article Snippet: These results indicate that blockade of 4α-PDD-induced hypotension by RuR is mainly mediated by antagonizing TRPV4 instead of TRPV1, a result consistent with previous reports.

    Techniques: Western Blot, Expressing

    Western blot analysis of protein expression of TRPV4 in the renal cortex and medulla of DR or DS rats. Values are mean ± SE (n=4∼5). *P

    Journal: Hypertension

    Article Title: Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism

    doi: 10.1161/HYPERTENSIONAHA.109.147710

    Figure Lengend Snippet: Western blot analysis of protein expression of TRPV4 in the renal cortex and medulla of DR or DS rats. Values are mean ± SE (n=4∼5). *P

    Article Snippet: These results indicate that blockade of 4α-PDD-induced hypotension by RuR is mainly mediated by antagonizing TRPV4 instead of TRPV1, a result consistent with previous reports.

    Techniques: Western Blot, Expressing

    Confocal microscopic images of Cy3-labeled TRPV4 staining of mesenteric arteries in DR or DS rats fed a LS or HS diet. Negative controls were performed by omission of primary antibodies using DR rats fed a HS diet. Scale bars, 20μm

    Journal: Hypertension

    Article Title: Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism

    doi: 10.1161/HYPERTENSIONAHA.109.147710

    Figure Lengend Snippet: Confocal microscopic images of Cy3-labeled TRPV4 staining of mesenteric arteries in DR or DS rats fed a LS or HS diet. Negative controls were performed by omission of primary antibodies using DR rats fed a HS diet. Scale bars, 20μm

    Article Snippet: These results indicate that blockade of 4α-PDD-induced hypotension by RuR is mainly mediated by antagonizing TRPV4 instead of TRPV1, a result consistent with previous reports.

    Techniques: Labeling, Staining

    Effects of TRPV1 activation in the presence or absence of TRPV4 blockade

    Journal: Hypertension

    Article Title: Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism

    doi: 10.1161/HYPERTENSIONAHA.109.147710

    Figure Lengend Snippet: Effects of TRPV1 activation in the presence or absence of TRPV4 blockade

    Article Snippet: These results indicate that blockade of 4α-PDD-induced hypotension by RuR is mainly mediated by antagonizing TRPV4 instead of TRPV1, a result consistent with previous reports.

    Techniques: Activation Assay