Structured Review

GeneTex trim3
<t>TRIM3</t> suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Trim3, supplied by GeneTex, used in various techniques. Bioz Stars score: 90/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 6 article reviews
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trim3 - by Bioz Stars, 2020-09
90/100 stars

Images

1) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

2) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

3) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

4) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

5) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

6) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

7) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

8) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

9) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

10) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

11) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

12) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

13) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

14) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

15) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

16) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

17) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

18) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

19) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

20) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

21) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

22) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

23) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

24) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

25) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

26) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

27) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

28) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

29) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

30) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

31) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

32) Product Images from "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma"

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-13-3703

TRIM3 attenuates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 regulates Musashi/Numb signaling
Figure Legend Snippet: TRIM3 regulates Musashi/Numb signaling

Techniques Used:

TRIM3 expression is reduced in human GBMs
Figure Legend Snippet: TRIM3 expression is reduced in human GBMs

Techniques Used: Expressing

TRIM3 expression reduces cell proliferation and glioma growth
Figure Legend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

Techniques Used: Expressing

TRIM3 regulates the stem cell population in GBM neurosphere cultures
Figure Legend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

Techniques Used:

TRIM3 suppresses c-Myc expression
Figure Legend Snippet: TRIM3 suppresses c-Myc expression

Techniques Used: Expressing

TRIM3 , the human homolog of Drosophila brat is deleted in GBMs
Figure Legend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

Techniques Used:

33) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

34) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

35) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

36) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

37) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

38) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

39) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

40) Product Images from "Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport"

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-15-2299

TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus
Figure Legend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

Techniques Used: Expressing, Translocation Assay

TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells
Figure Legend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

Techniques Used:

TRIM3 restricts active NICD transport to nucleus in glioma stem cells
Figure Legend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

Techniques Used:

Related Articles

Western Blot:

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport
Article Snippet: .. To test this, we performed a western blot for Importin α3 and Importin β1 in GBM neurospheres that differentially express TRIM3. .. We found that total (nuclear and cytoplasmic) Importin α3 expression was reduced following TRIM3 expression, but that total Importin β1 expression remained stable ( ).

other:

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma
Article Snippet: We next investigated TRIM3 for its effect on the ability of primary GBM cultures to form neurospheres, a GSC-dependent function.

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma
Article Snippet: In the TCGA GBM data, we observed that c-Myc was over-expressed and TRIM3 was under-expressed in nearly all GBM samples ( ).

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma
Article Snippet: However, the percentage of PKH-26 high cells in N08-74-TRIM3 cells was lower (0.47%) than N08-74-GFP cells (1.27%), suggesting that TRIM3 attenuates this GSC population ( ).

Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport
Article Snippet: TRIM is a large family with many members and here we provide evidence that at least one of its members, TRIM3, can directly bind and regulate nuclear transport in both normal and neoplastic stem cells.

Expressing:

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma
Article Snippet: .. We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members. .. TRIM3 was deleted in 22% of GBMs, whereas TRIM2, TRIM32 and TRIM71 were deleted in 12%, 11% and 10% of cases, respectively ( )[ ].

Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma
Article Snippet: .. We further probed these cultures for signaling pathways regulated by TRIM3 that might explain the discrepancy between c-Myc expression and its target genes. .. Since the Notch pathway is known to regulate p21, we started by investigating the Musashi/Notch pathway.

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    TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

    Journal: Cancer research

    Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

    doi: 10.1158/0008-5472.CAN-15-2299

    Figure Lengend Snippet: TRIM3 suppresses Importin expression and nuclear translocation affecting active Notch transport into nucleus

    Article Snippet: To test this, we performed a western blot for Importin α3 and Importin β1 in GBM neurospheres that differentially express TRIM3.

    Techniques: Expressing, Translocation Assay

    TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

    Journal: Cancer research

    Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

    doi: 10.1158/0008-5472.CAN-15-2299

    Figure Lengend Snippet: TRIM3, the mammalian ortholog of Brat attenuates NOTCH1 signal and reduces stemness in glioma cells

    Article Snippet: To test this, we performed a western blot for Importin α3 and Importin β1 in GBM neurospheres that differentially express TRIM3.

    Techniques:

    TRIM3 restricts active NICD transport to nucleus in glioma stem cells

    Journal: Cancer research

    Article Title: Drosophila Brat and human ortholog TRIM3 maintain stem cell equilibrium and suppress brain tumorigenesis by attenuating Notch nuclear transport

    doi: 10.1158/0008-5472.CAN-15-2299

    Figure Lengend Snippet: TRIM3 restricts active NICD transport to nucleus in glioma stem cells

    Article Snippet: To test this, we performed a western blot for Importin α3 and Importin β1 in GBM neurospheres that differentially express TRIM3.

    Techniques:

    TRIM3 attenuates the stem cell population in GBM neurosphere cultures

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 attenuates the stem cell population in GBM neurosphere cultures

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques:

    TRIM3 regulates Musashi/Numb signaling

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 regulates Musashi/Numb signaling

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques:

    TRIM3 expression is reduced in human GBMs

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 expression is reduced in human GBMs

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques: Expressing

    TRIM3 expression reduces cell proliferation and glioma growth

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 expression reduces cell proliferation and glioma growth

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques: Expressing

    TRIM3 regulates the stem cell population in GBM neurosphere cultures

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 regulates the stem cell population in GBM neurosphere cultures

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques:

    TRIM3 suppresses c-Myc expression

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 suppresses c-Myc expression

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques: Expressing

    TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

    Journal: Cancer research

    Article Title: Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

    doi: 10.1158/0008-5472.CAN-13-3703

    Figure Lengend Snippet: TRIM3 , the human homolog of Drosophila brat is deleted in GBMs

    Article Snippet: We focused our investigations on TRIM3 as the human ortholog because: 1) TRIM3 has the highest homology to Drosophila brat [ ] ( ); 2) TRIM3 is specifically expressed in human brain, much like the expression of brat is specific to Drosophila neural tissue; 3) SNP-based analysis of TRIM3 revealed loss in 25% of GBMs[ ] and our own probing of The Cancer Genome Atlas (TCGA) data indicated that TRIM3 has the highest frequency of deletion among TRIM family members.

    Techniques: