Review





Similar Products

thalidomide  (MedChemExpress)
93
MedChemExpress thalidomide
Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), <t>thalidomide</t> (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.
Thalidomide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/thalidomide/product/MedChemExpress
Average 93 stars, based on 1 article reviews
thalidomide - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
thalidomide  (Valiant Co Ltd)
94
Valiant Co Ltd thalidomide
Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), <t>thalidomide</t> (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.
Thalidomide, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/thalidomide/product/Valiant Co Ltd
Average 94 stars, based on 1 article reviews
thalidomide - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier
hy-41547  (medchemexpress)
93
medchemexpress hy-41547
Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), <t>thalidomide</t> (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.
Hy 41547, supplied by medchemexpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/hy-41547/product/medchemexpress
Average 93 stars, based on 1 article reviews
hy-41547 - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
crbn ligand inhibitor thalidomide  (TargetMol)
94
TargetMol crbn ligand inhibitor thalidomide
Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), <t>thalidomide</t> (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.
Crbn Ligand Inhibitor Thalidomide, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/crbn ligand inhibitor thalidomide/product/TargetMol
Average 94 stars, based on 1 article reviews
crbn ligand inhibitor thalidomide - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier
crbn-thalidomide interaction  (Boehringer Ingelheim)
90
Boehringer Ingelheim crbn-thalidomide interaction
Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), <t>thalidomide</t> (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.
Crbn Thalidomide Interaction, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/crbn-thalidomide interaction/product/Boehringer Ingelheim
Average 90 stars, based on 1 article reviews
crbn-thalidomide interaction - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
fluorescent probe cy5labeled thalidomide  (Tenova Pharmaceuticals Inc)
90
Tenova Pharmaceuticals Inc fluorescent probe cy5labeled thalidomide
Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), <t>thalidomide</t> (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.
Fluorescent Probe Cy5labeled Thalidomide, supplied by Tenova Pharmaceuticals Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fluorescent probe cy5labeled thalidomide/product/Tenova Pharmaceuticals Inc
Average 90 stars, based on 1 article reviews
fluorescent probe cy5labeled thalidomide - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), thalidomide (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.

Journal: Journal of Medicinal Chemistry

Article Title: Discovery of dCDK9-202 as a Highly Potent and Selective PROTAC CDK9 Degrader with Strong In Vivo Antitumor Activity

doi: 10.1021/acs.jmedchem.5c01111

Figure Lengend Snippet: Temporal effect and mechanistic investigation of 14 (dCDK9-202) on CDK9 degradation. (A) CDK9 protein levels in TC-71 cells upon time-course treatment with dCDK9-202 (10 nM). (B) Mechanistic investigation of CDK9 degradation induced by dCDK9-202 in the TC-71 cell line. Cells were pretreated 2 h with CDK9 inhibitor 6 (SNS032, 10 μM), thalidomide (10 μM), (R)-MG132 (5 μM), and MLN4924 (2 μM) followed by 4 h treatment with dCDK9-202 at 20 nM concentration.

Article Snippet: Apart from those synthesized in-house, additional chemicals used in culture assays included DMSO (Solarbio), SNS032 (MedChemExpress), THAL-SNS032 (MedChemExpress), thalidomide (MedChemExpress), (R)-MG132 (Targetmol), and MLN4924 (Targetmol).

Techniques: Concentration Assay