task3  (Alomone Labs)


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    Structured Review

    Alomone Labs task3
    TASK1 antagonist, anandamide (AEA) and <t>TASK3</t> antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Task3, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 32 article reviews
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    task3 - by Bioz Stars, 2022-09
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    Images

    1) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    2) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    3) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    4) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    5) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    6) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    7) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    8) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    9) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    10) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    11) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    12) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    13) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    14) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    15) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    16) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    17) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    18) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    19) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    20) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    21) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    22) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    23) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    24) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    25) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    26) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    27) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    28) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    29) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    30) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    31) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

    32) Product Images from "TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats"

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2018.00285

    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
    Figure Legend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Techniques Used: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.
    Figure Legend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Techniques Used:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.
    Figure Legend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Techniques Used:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .
    Figure Legend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Techniques Used: Negative Control

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    Alomone Labs task3
    TASK1 antagonist, anandamide (AEA) and <t>TASK3</t> antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p
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    TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Journal: Frontiers in Cellular Neuroscience

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    doi: 10.3389/fncel.2018.00285

    Figure Lengend Snippet: TASK1 antagonist, anandamide (AEA) and TASK3 antagonist, ruthenium red (RR) stimulated the respiration of rats. (A,B) The PND was recorded from the same animal. The unilateral microinjection of 100 μM AEA and 10 μM RR into the VLM increased PND and iPND. The microinjection of ethanol and ACSF (pH 7.4) served as a control. (C–F) Ti was decreased by AEA and RR injection. (D–G) Group data showing the effects of AEA and RR on iPND. (E–H) Responses of the respiratory drive. Note that AEA and RR stimulated respiration, * p

    Article Snippet: Colocalization of TASK1 and TASK3 in VLM Neurons To detect whether TASK1 and TASK3 are localized in VLM neurons, TASK1-ir and TASK3-ir cells were measured in rat VLM by double immunofluorescence.

    Techniques: Injection

    TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Journal: Frontiers in Cellular Neuroscience

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    doi: 10.3389/fncel.2018.00285

    Figure Lengend Snippet: TASK1 and TASK3 are expressed and colocalized in VLM neurons. (A,B) Representative confocal photomicrograph showing the colocalization of TASK1-ir and TASK3-ir (green) with neurofilament-ir (red) in the VLM. (C) Representative confocal photomicrograph showing the colocalization of TASK1 (red) and TASK3 (green) in the VLM. Original magnification, 200×.

    Article Snippet: Colocalization of TASK1 and TASK3 in VLM Neurons To detect whether TASK1 and TASK3 are localized in VLM neurons, TASK1-ir and TASK3-ir cells were measured in rat VLM by double immunofluorescence.

    Techniques:

    Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Journal: Frontiers in Cellular Neuroscience

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    doi: 10.3389/fncel.2018.00285

    Figure Lengend Snippet: Acid-sensing ion channel 1 (ASIC1), TASK1 and TASK3 are expressed and colocalized in the VLM neurons of adult rats. (A) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK1-ir (red) and neurofilament-H (blue) in the VLM. (B) Representative high power visual field of the area shown in (A) . (C) Representative confocal photomicrographs showing the colocalization of ASIC1-ir (green), TASK3-ir (red) and neurofilament-H (blue) in the VLM. (D) Representative high power visual field of the area shown in (C) . (A–C) Scale bar = 200 μm; (B,D) scale bar = 20 μm.

    Article Snippet: Colocalization of TASK1 and TASK3 in VLM Neurons To detect whether TASK1 and TASK3 are localized in VLM neurons, TASK1-ir and TASK3-ir cells were measured in rat VLM by double immunofluorescence.

    Techniques:

    The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Journal: Frontiers in Cellular Neuroscience

    Article Title: TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats

    doi: 10.3389/fncel.2018.00285

    Figure Lengend Snippet: The location of TWIK-related acid-sensitive potassium channel 1 and 3 (TASK1 and 3)-positive cells in the ventrolateral medulla (VLM) of SD rats. (A) TASK1-positive cells were located in the VLM of rats. (B,C) represent high-power visual fields of the area shown in (A) , showing a detailed view of TASK1-positive cells in the VLM. (D) TASK3-positive cells in the VLM of rats. (E,F) represent high-power visual fields of the area shown in (D) , showing a detailed view of TASK3-positive cells in the VLM. (G) Coronal diagram of the rat medulla; the area shown in black represents the distribution of TASK1 and TASK3. Cell morphology is indicated by the arrows shown in (C,F) . (H–I) Negative control. Scale bar: 200 μm (A,D,H,I) ; 80 μm (B,E) and 20 μm (C,F) .

    Article Snippet: Colocalization of TASK1 and TASK3 in VLM Neurons To detect whether TASK1 and TASK3 are localized in VLM neurons, TASK1-ir and TASK3-ir cells were measured in rat VLM by double immunofluorescence.

    Techniques: Negative Control