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Journal: Frontiers in Immunology
Article Title: Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect of piceatannol on rheumatoid arthritis
doi: 10.3389/fimmu.2026.1804844
Figure Lengend Snippet: Molecular docking, PIC and the six hub genes, SYK, CXCL8, TNF, NFKB1, PPARG and CASP8.
Article Snippet:
Techniques:
Journal: Frontiers in Immunology
Article Title: Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect of piceatannol on rheumatoid arthritis
doi: 10.3389/fimmu.2026.1804844
Figure Lengend Snippet: Further determination of PIC target genes and construction of the ceRNAs network. (A) Signature reversal analysis of the SYK and PIC; (B) Immune−related genes; (C) Identified miRNAs targeting SYK; (D) The intersection of the prediction results yielded 80 highly confident miRNAs; (E) The starBase and LncBase databases predict target lncRNAs.
Article Snippet:
Techniques:
Journal: Frontiers in Immunology
Article Title: Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect of piceatannol on rheumatoid arthritis
doi: 10.3389/fimmu.2026.1804844
Figure Lengend Snippet: Molecular dynamics simulations of PIC and SYK. (A) Root-mean-square deviation; (B) Root-mean-square fluctuation; (C) Radius of gyration; (D) Olventaccessible surface area; (E) Number of protein–ligand hydrogen bonds; (F-G) Free energy landscape.
Article Snippet:
Techniques:
Journal: Frontiers in Immunology
Article Title: Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect of piceatannol on rheumatoid arthritis
doi: 10.3389/fimmu.2026.1804844
Figure Lengend Snippet: Gene set enrichment analysis of SYK; (A) GO enrichment analysis, include biological process, cellular component, and molecular function; (B) KEGG enrichment analysis.
Article Snippet:
Techniques: