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(A) STAT3 activation in <t>HEK-Blue</t> <t>IL-23</t> reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.
Stat3 Activation, supplied by InvivoGen, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat3+activation/HEK-Blue+IL-23+Cells/bio_rxiv__64898__2026__07__22__740186-82-0-8
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stat3 activator  (MedChemExpress)
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(A) STAT3 activation in <t>HEK-Blue</t> <t>IL-23</t> reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.
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s pectasol c modified citrus pectin targets galectin 3 induced stat3 activation  (Galectin Therapeutics)
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(A) STAT3 activation in <t>HEK-Blue</t> <t>IL-23</t> reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.
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activator  (Proteintech)
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(A) STAT3 activation in <t>HEK-Blue</t> <t>IL-23</t> reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.
Activator, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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colivelin  (MedChemExpress)
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(A) STAT3 activation in <t>HEK-Blue</t> <t>IL-23</t> reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.
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Average 95 stars, based on 1 article reviews
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activator transcription 3  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc activator transcription 3
(A) STAT3 activation in <t>HEK-Blue</t> <t>IL-23</t> reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.
Activator Transcription 3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 98 stars, based on 1 article reviews
activator transcription 3 - by Bioz Stars, 2026-11
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(A) STAT3 activation in HEK-Blue IL-23 reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.

Journal: bioRxiv

Article Title: Microbial Immunomodulatory Function is Altered in Inflammatory Bowel Disease Independent of Microbial Composition

doi: 10.64898/2026.07.22.740186

Figure Lengend Snippet: (A) STAT3 activation in HEK-Blue IL-23 reporter cells treated with cell-free faecal water from non-IBD controls, UC patients, and CD patients in the absence (A) or presence (B) of IL-23 stimulation (5 ng/ml). STAT3 activity is expressed as % to IL-23 treated cells Each symbol represents an individual subject. Statistical comparisons by Kruskal-Wallis test with Dunn’s post-hoc correction. (C) Proportion of bacterial isolates classified as STAT3-suppressive, neutral, or STAT3-activating in non-IBD controls, UC patients, and CD patients, tested on HEK-Blue IL-23 reporter cells in the presence of IL-23 stimulation. Significance is denoted as follows: *p < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001; ns, not significant.

Article Snippet: STAT3 activation was assessed using HEK-Blue IL-23 cells (InvivoGen), which are HEK293 cells stably transfected with human IL-23 receptor, IL-12Rβ1, and a STAT3-responsive secreted embryonic alkaline phosphatase (SEAP) reporter.

Techniques: Activation Assay, Activity Assay

(A) IL-23 concentrations in faecal water from non-IBD, UC, and CD subjects measured by ELISA. Each dot represents an individual subject. IL-23 was below the limit of detection in all samples, indicating that the NF-κB and STAT3 activation observed in reporter assays was not attributable to residual cytokine content in faecal water. (B) IL-6 concentrations in faecal water from non-IBD, UC, and CD subjects. Each dot represents an individual subject. IL-6 was below the limit of detection in all samples. (C) IL-8 concentrations in faecal water from non-IBD, UC, and CD subjects. Each dot represents an individual subject. IL-8 was below the limit of detection in all samples. (D) TNF concentrations in faecal water from non-IBD, UC, and CD subjects. Each dot represents an individual subject. TNF was below the limit of detection in all samples. Dotted lines indicate the lower limit of detection for each assay.

Journal: bioRxiv

Article Title: Microbial Immunomodulatory Function is Altered in Inflammatory Bowel Disease Independent of Microbial Composition

doi: 10.64898/2026.07.22.740186

Figure Lengend Snippet: (A) IL-23 concentrations in faecal water from non-IBD, UC, and CD subjects measured by ELISA. Each dot represents an individual subject. IL-23 was below the limit of detection in all samples, indicating that the NF-κB and STAT3 activation observed in reporter assays was not attributable to residual cytokine content in faecal water. (B) IL-6 concentrations in faecal water from non-IBD, UC, and CD subjects. Each dot represents an individual subject. IL-6 was below the limit of detection in all samples. (C) IL-8 concentrations in faecal water from non-IBD, UC, and CD subjects. Each dot represents an individual subject. IL-8 was below the limit of detection in all samples. (D) TNF concentrations in faecal water from non-IBD, UC, and CD subjects. Each dot represents an individual subject. TNF was below the limit of detection in all samples. Dotted lines indicate the lower limit of detection for each assay.

Article Snippet: STAT3 activation was assessed using HEK-Blue IL-23 cells (InvivoGen), which are HEK293 cells stably transfected with human IL-23 receptor, IL-12Rβ1, and a STAT3-responsive secreted embryonic alkaline phosphatase (SEAP) reporter.

Techniques: Enzyme-linked Immunosorbent Assay, Activation Assay

(A–C) Individual-level breakdown of NF-κB immunomodulatory activity for bacterial isolates from each subject. Isolates are classified as suppressive (≥50% reduction in TNF-α-induced NF-κB activation), no activity (comparable to medium + TNF-α control), or activating (enhanced NF-κB activation above TNF-α-stimulated control). (A) Non-IBD subjects. (B) UC patients. (C) CD patients. Each coloured dot represents an individual subject, with the proportion of each functional category shown per subject. Non-IBD controls harboured significantly more suppressive isolates (21.52%) compared to UC (5.64%) and CD (2.45%), while UC and CD patients harboured significantly more activating isolates (34.47% and 39.36%, respectively) compared to non-IBD controls (5.35%). (D–F) Individual-level breakdown of STAT3 immunomodulatory activity for bacterial isolates tested on HEK-Blue IL-23 reporter cells. Isolates are classified as suppressive, no activity, or activating based on their effect on IL-23-mediated STAT3 activation. (D) Non-IBD subjects. (E) UC patients. (F) CD patients. Each coloured dot represents an individual subject. A similar trend to NF-κB was observed, with non-IBD controls harbouring more STAT3-suppressive isolates and IBD patients harbouring more STAT3-activating isolates.

Journal: bioRxiv

Article Title: Microbial Immunomodulatory Function is Altered in Inflammatory Bowel Disease Independent of Microbial Composition

doi: 10.64898/2026.07.22.740186

Figure Lengend Snippet: (A–C) Individual-level breakdown of NF-κB immunomodulatory activity for bacterial isolates from each subject. Isolates are classified as suppressive (≥50% reduction in TNF-α-induced NF-κB activation), no activity (comparable to medium + TNF-α control), or activating (enhanced NF-κB activation above TNF-α-stimulated control). (A) Non-IBD subjects. (B) UC patients. (C) CD patients. Each coloured dot represents an individual subject, with the proportion of each functional category shown per subject. Non-IBD controls harboured significantly more suppressive isolates (21.52%) compared to UC (5.64%) and CD (2.45%), while UC and CD patients harboured significantly more activating isolates (34.47% and 39.36%, respectively) compared to non-IBD controls (5.35%). (D–F) Individual-level breakdown of STAT3 immunomodulatory activity for bacterial isolates tested on HEK-Blue IL-23 reporter cells. Isolates are classified as suppressive, no activity, or activating based on their effect on IL-23-mediated STAT3 activation. (D) Non-IBD subjects. (E) UC patients. (F) CD patients. Each coloured dot represents an individual subject. A similar trend to NF-κB was observed, with non-IBD controls harbouring more STAT3-suppressive isolates and IBD patients harbouring more STAT3-activating isolates.

Article Snippet: STAT3 activation was assessed using HEK-Blue IL-23 cells (InvivoGen), which are HEK293 cells stably transfected with human IL-23 receptor, IL-12Rβ1, and a STAT3-responsive secreted embryonic alkaline phosphatase (SEAP) reporter.

Techniques: Activity Assay, Activation Assay, Control, Functional Assay