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LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
Anti P62, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p62  (ABclonal Biotechnology)
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LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
P62, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti p62  (ABclonal Biotechnology)
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LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
Rabbit Anti P62, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sqstm1/%5BKO+Validated%5D+SQSTM1+%2F+p62+Rabbit+mAb/pm42906440-84-98-102
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LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
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p62 sqstm1 - by Bioz Stars, 2026-11
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LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
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LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
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rabbit anti p62 primary antibody  (Proteintech)
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Proteintech rabbit anti p62 primary antibody
LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
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rabbit anti p62 primary antibody - by Bioz Stars, 2026-11
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anti p62 sqstm1  (Santa Cruz Biotechnology)
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Santa Cruz Biotechnology anti p62 sqstm1
LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, <t>P62),</t> lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
Anti P62 Sqstm1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, P62), lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001

Journal: Molecular Biomedicine

Article Title: Lipid nanoparticle-mediated transcription factor EB mRNA delivery for the treatment of metabolic dysfunction-associated steatotic liver disease

doi: 10.1186/s43556-026-00615-0

Figure Lengend Snippet: LNP-TFEB and S211A enhanced autophagy and promoted lipid metabolism in the mouse liver. a Representative Western blot images and b corresponding quantitative analysis of TFEB (TFEB and FLAG-tag detection confirmed LNP-mediated expression of TFEB and S211A), autophagy-related proteins (LC3, P62), lipid metabolism-related proteins (PPARα, ATGL, CPT1A) and lipid synthesis-related proteins (FASN, ACC, SREBP1) in mouse liver ( n = 4 or 6 per group). c Relative hepatic mRNA expression levels of autophagy-related genes, lipid catabolism-related genes and lipid synthesis and transport-related genes, as determined by qPCR ( n = 5 or 6 per group). d Representative hematoxylin and eosin (H&E) staining images of liver sections and the corresponding NAFLD activity score (NAS) ( n = 6 per group). e Representative images of Sirius Red staining and quantification of the relative fibrotic area ( n = 6 per group). f Representative BODIPY fluorescence staining images of neutral lipids in liver sections and quantification of fluorescence intensity. cv: Central vein ( n = 6 per group). g Representative F4/80 immunofluorescence staining images showing macrophage infiltration and the corresponding quantitative analysis ( n = 5 per group). Scale bar = 100 μm. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001

Article Snippet: The membranes were blocked with 5% skim milk for 2 h and then incubated overnight at 4 °C with the following primary antibodies: anti-TFEB (1:1,000, Bethyl, A303-673A), anti-LC3 (1:1,000, Abclonal, A15591), anti-p62 (1:1,000, Abclonal, A7758), anti-phospho-eIF4EBP1 (1:1,000, Abclonal, AP1363), anti-eIF4EBP1 (1:1,000, Abclonal, A24691), anti-FGF21 (1:1,000, Abclonal, A23463), anti-FASN (1:1,000, Epyzime, R013857), anti-SREBP1 (1:1,000, Epyzime, P010134), anti-ACC (1:1,000, Epyzime, P105115), anti-CPT1A (1:1,000, Epyzime, P106431), anti-PPARα (1:1,000, Epyzime, P010554), anti-ATGL (1:1,000, Epyzime, R011456), and anti-β-actin (1:1,000, Proteintech, 20,536–1-AP).

Techniques: Western Blot, Analysis, FLAG-tag, Expressing, Staining, Activity Assay, Fluorescence, Immunofluorescence