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Charles River Laboratories adult male sprague dawley rats
Adult Male Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Charles River Laboratories female sprague dawley rats
Female Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Tptx Crl Cd Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Charles River Laboratories sprague dawley rats
Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sprague dawley rats/product/Charles River Laboratories
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Charles River Laboratories sprague dawley rats
Chronic CDDP exposure and medical stress affect cognitive function and serum BDNF levels in a female middle-aged rat model. (A) Schematic representation of the experimental design. 9-month-old female retired-breeder <t>Sprague</t> <t>Dawley</t> rats were injected with vehicle (SAL, saline, n = 8) or cisplatin (CDDP, 2.5 mg/kg, i. p., n = 12) once every two weeks for 13 weeks. CDDP and SAL rats were subjected to the medical stress protocol, which included hydration therapy (5–10 mL 0.9% saline/day, s.q.) for five consecutive days during CDDP treatment and lateral tail vein blood collections 72 h after each CDDP dose. Cage mates that did not receive CDDP/SAL injections nor blood collections served as healthy age-matched controls (CON, n = 8) for this study. Fourteen weeks after the start of CDDP treatment, all rats were assessed for anxiogenic behavior using the open field recognition test (OFT) and cognitive function using the novel object recognition task (NOR). Rats were euthanized ten weeks following the completion of CDDP, and serum was collected for BDNF analyses. (B) Effect of CDDP regimen on body weight (grams) over time. Quantification of (C) time spent in the center zone and (D) number of entrances to the center zone of the arena over 10 min in the OFT. (E) Quantification of total time spent exploring novel and familiar objects during NOR. (F) Medical stress and CDDP treatment impaired cognitive function as SAL and CDDP rats had a reduced preference for the novel object compared to the familiar object during NOR. (G) CDDP-exposed rats had a significantly lower discrimination ratio [(novel object exploration (sec))/(total object exploration (sec))] compared to healthy age-matched controls (CON). Data are shown as mean ± SEM; each point represents one rat (C-G). Not significant = ns, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001, as determined by one-way ANOVA with Tukey’s post hoc analysis for multiple comparisons test. Figure prepared with BioRender.
Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sprague dawley rats/product/Charles River Laboratories
Average 86 stars, based on 1 article reviews
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sprague dawley rats - by Bioz Stars, 2024-05
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1) Product Images from "Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity"

Article Title: Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity

Journal: Experimental neurology

doi: 10.1016/j.expneurol.2024.114717

Chronic CDDP exposure and medical stress affect cognitive function and serum BDNF levels in a female middle-aged rat model. (A) Schematic representation of the experimental design. 9-month-old female retired-breeder Sprague Dawley rats were injected with vehicle (SAL, saline, n = 8) or cisplatin (CDDP, 2.5 mg/kg, i. p., n = 12) once every two weeks for 13 weeks. CDDP and SAL rats were subjected to the medical stress protocol, which included hydration therapy (5–10 mL 0.9% saline/day, s.q.) for five consecutive days during CDDP treatment and lateral tail vein blood collections 72 h after each CDDP dose. Cage mates that did not receive CDDP/SAL injections nor blood collections served as healthy age-matched controls (CON, n = 8) for this study. Fourteen weeks after the start of CDDP treatment, all rats were assessed for anxiogenic behavior using the open field recognition test (OFT) and cognitive function using the novel object recognition task (NOR). Rats were euthanized ten weeks following the completion of CDDP, and serum was collected for BDNF analyses. (B) Effect of CDDP regimen on body weight (grams) over time. Quantification of (C) time spent in the center zone and (D) number of entrances to the center zone of the arena over 10 min in the OFT. (E) Quantification of total time spent exploring novel and familiar objects during NOR. (F) Medical stress and CDDP treatment impaired cognitive function as SAL and CDDP rats had a reduced preference for the novel object compared to the familiar object during NOR. (G) CDDP-exposed rats had a significantly lower discrimination ratio [(novel object exploration (sec))/(total object exploration (sec))] compared to healthy age-matched controls (CON). Data are shown as mean ± SEM; each point represents one rat (C-G). Not significant = ns, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001, as determined by one-way ANOVA with Tukey’s post hoc analysis for multiple comparisons test. Figure prepared with BioRender.
Figure Legend Snippet: Chronic CDDP exposure and medical stress affect cognitive function and serum BDNF levels in a female middle-aged rat model. (A) Schematic representation of the experimental design. 9-month-old female retired-breeder Sprague Dawley rats were injected with vehicle (SAL, saline, n = 8) or cisplatin (CDDP, 2.5 mg/kg, i. p., n = 12) once every two weeks for 13 weeks. CDDP and SAL rats were subjected to the medical stress protocol, which included hydration therapy (5–10 mL 0.9% saline/day, s.q.) for five consecutive days during CDDP treatment and lateral tail vein blood collections 72 h after each CDDP dose. Cage mates that did not receive CDDP/SAL injections nor blood collections served as healthy age-matched controls (CON, n = 8) for this study. Fourteen weeks after the start of CDDP treatment, all rats were assessed for anxiogenic behavior using the open field recognition test (OFT) and cognitive function using the novel object recognition task (NOR). Rats were euthanized ten weeks following the completion of CDDP, and serum was collected for BDNF analyses. (B) Effect of CDDP regimen on body weight (grams) over time. Quantification of (C) time spent in the center zone and (D) number of entrances to the center zone of the arena over 10 min in the OFT. (E) Quantification of total time spent exploring novel and familiar objects during NOR. (F) Medical stress and CDDP treatment impaired cognitive function as SAL and CDDP rats had a reduced preference for the novel object compared to the familiar object during NOR. (G) CDDP-exposed rats had a significantly lower discrimination ratio [(novel object exploration (sec))/(total object exploration (sec))] compared to healthy age-matched controls (CON). Data are shown as mean ± SEM; each point represents one rat (C-G). Not significant = ns, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001, as determined by one-way ANOVA with Tukey’s post hoc analysis for multiple comparisons test. Figure prepared with BioRender.

Techniques Used: Injection, Saline


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Charles River Laboratories sixteen adult female sprague dawley rats
Sixteen Adult Female Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sixteen adult female sprague dawley rats/product/Charles River Laboratories
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Charles River Laboratories male sprague dawley rats
Male Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/male sprague dawley rats/product/Charles River Laboratories
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
male sprague dawley rats - by Bioz Stars, 2024-05
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Charles River Laboratories sprague dawley rats
Chronic CDDP exposure and medical stress affect cognitive function and serum BDNF levels in a female middle-aged rat model. (A) Schematic representation of the experimental design. 9-month-old female retired-breeder <t>Sprague</t> <t>Dawley</t> rats were injected with vehicle (SAL, saline, n = 8) or cisplatin (CDDP, 2.5 mg/kg, i. p., n = 12) once every two weeks for 13 weeks. CDDP and SAL rats were subjected to the medical stress protocol, which included hydration therapy (5–10 mL 0.9% saline/day, s.q.) for five consecutive days during CDDP treatment and lateral tail vein blood collections 72 h after each CDDP dose. Cage mates that did not receive CDDP/SAL injections nor blood collections served as healthy age-matched controls (CON, n = 8) for this study. Fourteen weeks after the start of CDDP treatment, all rats were assessed for anxiogenic behavior using the open field recognition test (OFT) and cognitive function using the novel object recognition task (NOR). Rats were euthanized ten weeks following the completion of CDDP, and serum was collected for BDNF analyses. (B) Effect of CDDP regimen on body weight (grams) over time. Quantification of (C) time spent in the center zone and (D) number of entrances to the center zone of the arena over 10 min in the OFT. (E) Quantification of total time spent exploring novel and familiar objects during NOR. (F) Medical stress and CDDP treatment impaired cognitive function as SAL and CDDP rats had a reduced preference for the novel object compared to the familiar object during NOR. (G) CDDP-exposed rats had a significantly lower discrimination ratio [(novel object exploration (sec))/(total object exploration (sec))] compared to healthy age-matched controls (CON). Data are shown as mean ± SEM; each point represents one rat (C-G). Not significant = ns, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001, as determined by one-way ANOVA with Tukey’s post hoc analysis for multiple comparisons test. Figure prepared with BioRender.
Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sprague dawley rats/product/Charles River Laboratories
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
sprague dawley rats - by Bioz Stars, 2024-05
86/100 stars

Images

1) Product Images from "Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity"

Article Title: Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity

Journal: Experimental neurology

doi: 10.1016/j.expneurol.2024.114717

Chronic CDDP exposure and medical stress affect cognitive function and serum BDNF levels in a female middle-aged rat model. (A) Schematic representation of the experimental design. 9-month-old female retired-breeder Sprague Dawley rats were injected with vehicle (SAL, saline, n = 8) or cisplatin (CDDP, 2.5 mg/kg, i. p., n = 12) once every two weeks for 13 weeks. CDDP and SAL rats were subjected to the medical stress protocol, which included hydration therapy (5–10 mL 0.9% saline/day, s.q.) for five consecutive days during CDDP treatment and lateral tail vein blood collections 72 h after each CDDP dose. Cage mates that did not receive CDDP/SAL injections nor blood collections served as healthy age-matched controls (CON, n = 8) for this study. Fourteen weeks after the start of CDDP treatment, all rats were assessed for anxiogenic behavior using the open field recognition test (OFT) and cognitive function using the novel object recognition task (NOR). Rats were euthanized ten weeks following the completion of CDDP, and serum was collected for BDNF analyses. (B) Effect of CDDP regimen on body weight (grams) over time. Quantification of (C) time spent in the center zone and (D) number of entrances to the center zone of the arena over 10 min in the OFT. (E) Quantification of total time spent exploring novel and familiar objects during NOR. (F) Medical stress and CDDP treatment impaired cognitive function as SAL and CDDP rats had a reduced preference for the novel object compared to the familiar object during NOR. (G) CDDP-exposed rats had a significantly lower discrimination ratio [(novel object exploration (sec))/(total object exploration (sec))] compared to healthy age-matched controls (CON). Data are shown as mean ± SEM; each point represents one rat (C-G). Not significant = ns, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001, as determined by one-way ANOVA with Tukey’s post hoc analysis for multiple comparisons test. Figure prepared with BioRender.
Figure Legend Snippet: Chronic CDDP exposure and medical stress affect cognitive function and serum BDNF levels in a female middle-aged rat model. (A) Schematic representation of the experimental design. 9-month-old female retired-breeder Sprague Dawley rats were injected with vehicle (SAL, saline, n = 8) or cisplatin (CDDP, 2.5 mg/kg, i. p., n = 12) once every two weeks for 13 weeks. CDDP and SAL rats were subjected to the medical stress protocol, which included hydration therapy (5–10 mL 0.9% saline/day, s.q.) for five consecutive days during CDDP treatment and lateral tail vein blood collections 72 h after each CDDP dose. Cage mates that did not receive CDDP/SAL injections nor blood collections served as healthy age-matched controls (CON, n = 8) for this study. Fourteen weeks after the start of CDDP treatment, all rats were assessed for anxiogenic behavior using the open field recognition test (OFT) and cognitive function using the novel object recognition task (NOR). Rats were euthanized ten weeks following the completion of CDDP, and serum was collected for BDNF analyses. (B) Effect of CDDP regimen on body weight (grams) over time. Quantification of (C) time spent in the center zone and (D) number of entrances to the center zone of the arena over 10 min in the OFT. (E) Quantification of total time spent exploring novel and familiar objects during NOR. (F) Medical stress and CDDP treatment impaired cognitive function as SAL and CDDP rats had a reduced preference for the novel object compared to the familiar object during NOR. (G) CDDP-exposed rats had a significantly lower discrimination ratio [(novel object exploration (sec))/(total object exploration (sec))] compared to healthy age-matched controls (CON). Data are shown as mean ± SEM; each point represents one rat (C-G). Not significant = ns, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001, as determined by one-way ANOVA with Tukey’s post hoc analysis for multiple comparisons test. Figure prepared with BioRender.

Techniques Used: Injection, Saline


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Charles River Laboratories sprague dawley rats
Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sprague dawley rats/product/Charles River Laboratories
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
sprague dawley rats - by Bioz Stars, 2024-05
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Charles River Laboratories adult male sprague dawley rats
Representative scheme of the hypothesis and protocol Hypothesis (A). The OVLT mediates changes in the gut microbiome associated with concomitant hypertension. Experimental protocol (B). 1) Adult <t>male</t> <t>Sprague-Dawley</t> rats were randomly selected for either OVLT lesion (OVLTx) or sham operation (OVLTsham). 2) After a one-week recovery, rats underwent radio-telemeter implantation and right unilateral nephrectomy. After two weeks of recovery, all rats were given 2.0% NaCl diet and ad libitum 0.9% NaCl drinking solution. After 5 control days, rats were briefly anesthetized and a 100 mg DOCA pellet was implanted subcutaneously in each rat. Daily measurements were made of blood pressure and heart rate. 3) Rats were deeply anesthetized with pentobarbital and intestinal sections (jejunum, ileum, cecum and colon) from normal control rats, and DOCA treated OVLTx and sham rats were taken and frozen for microbiome analysis. OVLTx and sham rats were then perfused with 4% paraformaldehyde. The brains were removed and histologically verified for sham or OVLT lesion.
Adult Male Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/adult male sprague dawley rats/product/Charles River Laboratories
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
adult male sprague dawley rats - by Bioz Stars, 2024-05
86/100 stars

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1) Product Images from "DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis"

Article Title: DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis

Journal: Clinical and experimental pharmacology & physiology

doi: 10.1111/1440-1681.13457

Representative scheme of the hypothesis and protocol Hypothesis (A). The OVLT mediates changes in the gut microbiome associated with concomitant hypertension. Experimental protocol (B). 1) Adult male Sprague-Dawley rats were randomly selected for either OVLT lesion (OVLTx) or sham operation (OVLTsham). 2) After a one-week recovery, rats underwent radio-telemeter implantation and right unilateral nephrectomy. After two weeks of recovery, all rats were given 2.0% NaCl diet and ad libitum 0.9% NaCl drinking solution. After 5 control days, rats were briefly anesthetized and a 100 mg DOCA pellet was implanted subcutaneously in each rat. Daily measurements were made of blood pressure and heart rate. 3) Rats were deeply anesthetized with pentobarbital and intestinal sections (jejunum, ileum, cecum and colon) from normal control rats, and DOCA treated OVLTx and sham rats were taken and frozen for microbiome analysis. OVLTx and sham rats were then perfused with 4% paraformaldehyde. The brains were removed and histologically verified for sham or OVLT lesion.
Figure Legend Snippet: Representative scheme of the hypothesis and protocol Hypothesis (A). The OVLT mediates changes in the gut microbiome associated with concomitant hypertension. Experimental protocol (B). 1) Adult male Sprague-Dawley rats were randomly selected for either OVLT lesion (OVLTx) or sham operation (OVLTsham). 2) After a one-week recovery, rats underwent radio-telemeter implantation and right unilateral nephrectomy. After two weeks of recovery, all rats were given 2.0% NaCl diet and ad libitum 0.9% NaCl drinking solution. After 5 control days, rats were briefly anesthetized and a 100 mg DOCA pellet was implanted subcutaneously in each rat. Daily measurements were made of blood pressure and heart rate. 3) Rats were deeply anesthetized with pentobarbital and intestinal sections (jejunum, ileum, cecum and colon) from normal control rats, and DOCA treated OVLTx and sham rats were taken and frozen for microbiome analysis. OVLTx and sham rats were then perfused with 4% paraformaldehyde. The brains were removed and histologically verified for sham or OVLT lesion.

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    Charles River Laboratories adult male sprague dawley rats
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    Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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