sphingosine 1 phosphate s1p cayman  (Echelon Biosciences)


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    Echelon Biosciences sphingosine 1 phosphate s1p cayman
    Murine Plpp6 gene expression and activity is regulated during inflammation (A) PLPP6 converts presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP) upon cell activation. (B) Phosphate release from PSDP, <t>sphingosine-1-phosphate</t> <t>(S1P),</t> farnesyl diphosphate (FDP), phosphatidic acid (PA), and lysophosphatidic acid (LPA) exposed to recombinant murine PLPP6 (see ); experiments were performed 4 times for a total of n = 3 to 4. (C) Allergic lung inflammation model with house dust mite (HDM) exposure (see ). (D) Lung Plpp6 expression in WT mice on day 16 of HDM protocol; experiments were performed 2 times for a total of n = 4 to 7; data represent fold change relative to baseline expression. (E) Extracted ion chromatogram (MS-XIC) and MS/MS assignment of isolated PSMP ([M−H] = 505.35). (F) PSMP content in lungs from WT and Plpp6 −/− mice on day 16 of HDM protocol; results are expressed as fold change to the mean value of PSMP in the naive group of the same genotype; experiments were performed 3 times for a total of n = 3. ∗ p < 0.05 and ∗∗ p < 0.01 comparing S1P, FDP, PA, LPA to PSDP by one-way ANOVA and Tukey test for multiple comparisons. ## p < 0.01 comparing inflammation to baseline by unpaired nonparametric Mann-Whitney test. Bars represent median with interquartile range. See also <xref ref-type=Figure S1 . " width="250" height="auto" />
    Sphingosine 1 Phosphate S1p Cayman, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sphingosine 1 phosphate s1p cayman/product/Echelon Biosciences
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sphingosine 1 phosphate s1p cayman - by Bioz Stars, 2024-03
    93/100 stars

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    1) Product Images from "Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization"

    Article Title: Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization

    Journal: iScience

    doi: 10.1016/j.isci.2022.105185

    Murine Plpp6 gene expression and activity is regulated during inflammation (A) PLPP6 converts presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP) upon cell activation. (B) Phosphate release from PSDP, sphingosine-1-phosphate (S1P), farnesyl diphosphate (FDP), phosphatidic acid (PA), and lysophosphatidic acid (LPA) exposed to recombinant murine PLPP6 (see ); experiments were performed 4 times for a total of n = 3 to 4. (C) Allergic lung inflammation model with house dust mite (HDM) exposure (see ). (D) Lung Plpp6 expression in WT mice on day 16 of HDM protocol; experiments were performed 2 times for a total of n = 4 to 7; data represent fold change relative to baseline expression. (E) Extracted ion chromatogram (MS-XIC) and MS/MS assignment of isolated PSMP ([M−H] = 505.35). (F) PSMP content in lungs from WT and Plpp6 −/− mice on day 16 of HDM protocol; results are expressed as fold change to the mean value of PSMP in the naive group of the same genotype; experiments were performed 3 times for a total of n = 3. ∗ p < 0.05 and ∗∗ p < 0.01 comparing S1P, FDP, PA, LPA to PSDP by one-way ANOVA and Tukey test for multiple comparisons. ## p < 0.01 comparing inflammation to baseline by unpaired nonparametric Mann-Whitney test. Bars represent median with interquartile range. See also <xref ref-type=Figure S1 . " title="... upon cell activation. (B) Phosphate release from PSDP, sphingosine-1-phosphate (S1P), farnesyl diphosphate (FDP), phosphatidic acid (PA), and ..." property="contentUrl" width="100%" height="100%"/>
    Figure Legend Snippet: Murine Plpp6 gene expression and activity is regulated during inflammation (A) PLPP6 converts presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP) upon cell activation. (B) Phosphate release from PSDP, sphingosine-1-phosphate (S1P), farnesyl diphosphate (FDP), phosphatidic acid (PA), and lysophosphatidic acid (LPA) exposed to recombinant murine PLPP6 (see ); experiments were performed 4 times for a total of n = 3 to 4. (C) Allergic lung inflammation model with house dust mite (HDM) exposure (see ). (D) Lung Plpp6 expression in WT mice on day 16 of HDM protocol; experiments were performed 2 times for a total of n = 4 to 7; data represent fold change relative to baseline expression. (E) Extracted ion chromatogram (MS-XIC) and MS/MS assignment of isolated PSMP ([M−H] = 505.35). (F) PSMP content in lungs from WT and Plpp6 −/− mice on day 16 of HDM protocol; results are expressed as fold change to the mean value of PSMP in the naive group of the same genotype; experiments were performed 3 times for a total of n = 3. ∗ p < 0.05 and ∗∗ p < 0.01 comparing S1P, FDP, PA, LPA to PSDP by one-way ANOVA and Tukey test for multiple comparisons. ## p < 0.01 comparing inflammation to baseline by unpaired nonparametric Mann-Whitney test. Bars represent median with interquartile range. See also Figure S1 .

    Techniques Used: Expressing, Activity Assay, Activation Assay, Recombinant, Tandem Mass Spectroscopy, Isolation, MANN-WHITNEY


    Figure Legend Snippet:

    Techniques Used: Clone Assay, Recombinant, Enzyme-linked Immunosorbent Assay, Quantitation Assay, Software, Staining, Cell Stimulation, Antibody Labeling

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    Echelon Biosciences sphingosine 1 phosphate s1p cayman
    Murine Plpp6 gene expression and activity is regulated during inflammation (A) PLPP6 converts presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP) upon cell activation. (B) Phosphate release from PSDP, <t>sphingosine-1-phosphate</t> <t>(S1P),</t> farnesyl diphosphate (FDP), phosphatidic acid (PA), and lysophosphatidic acid (LPA) exposed to recombinant murine PLPP6 (see ); experiments were performed 4 times for a total of n = 3 to 4. (C) Allergic lung inflammation model with house dust mite (HDM) exposure (see ). (D) Lung Plpp6 expression in WT mice on day 16 of HDM protocol; experiments were performed 2 times for a total of n = 4 to 7; data represent fold change relative to baseline expression. (E) Extracted ion chromatogram (MS-XIC) and MS/MS assignment of isolated PSMP ([M−H] = 505.35). (F) PSMP content in lungs from WT and Plpp6 −/− mice on day 16 of HDM protocol; results are expressed as fold change to the mean value of PSMP in the naive group of the same genotype; experiments were performed 3 times for a total of n = 3. ∗ p < 0.05 and ∗∗ p < 0.01 comparing S1P, FDP, PA, LPA to PSDP by one-way ANOVA and Tukey test for multiple comparisons. ## p < 0.01 comparing inflammation to baseline by unpaired nonparametric Mann-Whitney test. Bars represent median with interquartile range. See also <xref ref-type=Figure S1 . " width="250" height="auto" />
    Sphingosine 1 Phosphate S1p Cayman, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sphingosine 1 phosphate s1p cayman/product/Echelon Biosciences
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sphingosine 1 phosphate s1p cayman - by Bioz Stars, 2024-03
    93/100 stars
      Buy from Supplier

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    Murine Plpp6 gene expression and activity is regulated during inflammation (A) PLPP6 converts presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP) upon cell activation. (B) Phosphate release from PSDP, sphingosine-1-phosphate (S1P), farnesyl diphosphate (FDP), phosphatidic acid (PA), and lysophosphatidic acid (LPA) exposed to recombinant murine PLPP6 (see ); experiments were performed 4 times for a total of n = 3 to 4. (C) Allergic lung inflammation model with house dust mite (HDM) exposure (see ). (D) Lung Plpp6 expression in WT mice on day 16 of HDM protocol; experiments were performed 2 times for a total of n = 4 to 7; data represent fold change relative to baseline expression. (E) Extracted ion chromatogram (MS-XIC) and MS/MS assignment of isolated PSMP ([M−H] = 505.35). (F) PSMP content in lungs from WT and Plpp6 −/− mice on day 16 of HDM protocol; results are expressed as fold change to the mean value of PSMP in the naive group of the same genotype; experiments were performed 3 times for a total of n = 3. ∗ p < 0.05 and ∗∗ p < 0.01 comparing S1P, FDP, PA, LPA to PSDP by one-way ANOVA and Tukey test for multiple comparisons. ## p < 0.01 comparing inflammation to baseline by unpaired nonparametric Mann-Whitney test. Bars represent median with interquartile range. See also <xref ref-type=Figure S1 . " width="100%" height="100%">

    Journal: iScience

    Article Title: Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization

    doi: 10.1016/j.isci.2022.105185

    Figure Lengend Snippet: Murine Plpp6 gene expression and activity is regulated during inflammation (A) PLPP6 converts presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP) upon cell activation. (B) Phosphate release from PSDP, sphingosine-1-phosphate (S1P), farnesyl diphosphate (FDP), phosphatidic acid (PA), and lysophosphatidic acid (LPA) exposed to recombinant murine PLPP6 (see ); experiments were performed 4 times for a total of n = 3 to 4. (C) Allergic lung inflammation model with house dust mite (HDM) exposure (see ). (D) Lung Plpp6 expression in WT mice on day 16 of HDM protocol; experiments were performed 2 times for a total of n = 4 to 7; data represent fold change relative to baseline expression. (E) Extracted ion chromatogram (MS-XIC) and MS/MS assignment of isolated PSMP ([M−H] = 505.35). (F) PSMP content in lungs from WT and Plpp6 −/− mice on day 16 of HDM protocol; results are expressed as fold change to the mean value of PSMP in the naive group of the same genotype; experiments were performed 3 times for a total of n = 3. ∗ p < 0.05 and ∗∗ p < 0.01 comparing S1P, FDP, PA, LPA to PSDP by one-way ANOVA and Tukey test for multiple comparisons. ## p < 0.01 comparing inflammation to baseline by unpaired nonparametric Mann-Whitney test. Bars represent median with interquartile range. See also Figure S1 .

    Article Snippet: Recombinant mPlpp6 (2μg) was added to mixed micelles of select phosphorylated lipids (presqualene diphosphate (PSDP) (isolated as in ( )), sphingosine-1-phosphate (S1P) (Cayman), farnesyl diphosphate (FDP) (Echelon), phosphatidic acid (PA) (Cayman) and lysophosphatidic acid (LPA) (Cayman)) (20μM) for 30 min at 37°C with gentle mixing.

    Techniques: Expressing, Activity Assay, Activation Assay, Recombinant, Tandem Mass Spectroscopy, Isolation, MANN-WHITNEY

    Journal: iScience

    Article Title: Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization

    doi: 10.1016/j.isci.2022.105185

    Figure Lengend Snippet:

    Article Snippet: Recombinant mPlpp6 (2μg) was added to mixed micelles of select phosphorylated lipids (presqualene diphosphate (PSDP) (isolated as in ( )), sphingosine-1-phosphate (S1P) (Cayman), farnesyl diphosphate (FDP) (Echelon), phosphatidic acid (PA) (Cayman) and lysophosphatidic acid (LPA) (Cayman)) (20μM) for 30 min at 37°C with gentle mixing.

    Techniques: Clone Assay, Recombinant, Enzyme-linked Immunosorbent Assay, Quantitation Assay, Software, Staining, Cell Stimulation, Antibody Labeling