Journal: Nature genetics

Article Title: Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

doi: 10.1038/ng.3195

Figure Lengend Snippet: (a) MStree based on 24 MIRU-VNTR markers delineating the clonal complexes (CCs) gathered from a worldwide collection (n = 4,987). Major nodes and associated multi-locus variants were grouped into six CCs and a basal sublineage (BL). (b) Genetic variability in the different Beijing lineage CCs and the BL calculated using a rarefaction procedure (each CC included a subsample of 457 strains drawn randomly from its source population). Dots correspond to the mean allelic richness, boxes correspond to mean values ± s.e.m. and error bars correspond to mean values ± s.d. (c) Worldwide distribution of the Beijing CCs and BL. Each circle corresponds to a country, and circle sizes are proportional to the number of strains. Note that the results for CC3 and CC4, less supported by whole genome-based analysis, are only given as an indication. (d) Genetic erosion out of China. Mean allelic richness within geographical populations is plotted against geographical distance from the Yangtze River basin. Filled squares denote the Eurasian samples used for the regression; filled circles correspond to the global collection. Confidence intervals are represented by dashed lines.

Article Snippet: The population structure based on 24-locus MIRU-VNTR data for 4,987 clinical M. tuberculosis Beijing isolates was inferred with the minimum spanning tree (MSTREE) algorithm implemented in BioNumerics software package v6.7 (Applied Maths).

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