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sirna mediated jnk1  (Revvity)


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    Revvity sirna mediated jnk1
    A HEK293 cells, depleted of <t>JNK1</t> with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.
    Sirna Mediated Jnk1, supplied by Revvity, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirna mediated jnk1/product/Revvity
    Average 86 stars, based on 1 article reviews
    sirna mediated jnk1 - by Bioz Stars, 2025-07
    86/100 stars

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    1) Product Images from "Stress pathway outputs are encoded by pH-dependent clustering of kinase components"

    Article Title: Stress pathway outputs are encoded by pH-dependent clustering of kinase components

    Journal: Nature Communications

    doi: 10.1038/s41467-024-50638-w

    A HEK293 cells, depleted of JNK1 with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.
    Figure Legend Snippet: A HEK293 cells, depleted of JNK1 with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.

    Techniques Used: Control, Activity Assay, Transfection



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    sirna mediated jnk1  (Revvity)
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    Revvity sirna mediated jnk1
    A HEK293 cells, depleted of <t>JNK1</t> with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.
    Sirna Mediated Jnk1, supplied by Revvity, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirna mediated jnk1/product/Revvity
    Average 86 stars, based on 1 article reviews
    sirna mediated jnk1 - by Bioz Stars, 2025-07
    86/100 stars
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    sirna mediated knockdown sirna against human jnk1  (Santa Cruz Biotechnology)
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    Santa Cruz Biotechnology sirna mediated knockdown sirna against human jnk1
    A HEK293 cells, depleted of <t>JNK1</t> with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.
    Sirna Mediated Knockdown Sirna Against Human Jnk1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    A HEK293 cells, depleted of JNK1 with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.

    Journal: Nature Communications

    Article Title: Stress pathway outputs are encoded by pH-dependent clustering of kinase components

    doi: 10.1038/s41467-024-50638-w

    Figure Lengend Snippet: A HEK293 cells, depleted of JNK1 with siRNA (1 to 25 pmol, n = 4) or treated with control siRNA (25 pmol, n = 12), were stimulated with TNFα (10 ng/ml) and change (Δ) in JNK activity (KTR) and pHi monitored over time (60 min). B TNFα-stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 3, 4, 3 for 1, 6, 25 pmol). C TNFα-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. D HEK293 cells, transfected with JNK1 ( n = 4, 3, 3 for 1, 6, 25 pmol) or control siRNA (25 pmol, n = 12), were stimulated with sorbitol (150 mM) and JNK activity and pHi change measured over time. E Sorbitol stimulated change in JNK activity and pHi in HEK293 cells depleted of JNK2 ( n = 4, 4, 3 for 1, 6, 25 pmol). F Sorbitol-stimulated change in pHi was correlated with JNK activity responses in JNK1 or JNK2-depleted cells. Values represent mean ± SEM from independent experiments (n). ΔKTR and ΔpHi values indicate a difference compared to before stimulation (0 min). ‘R’ indicates Pearson correlation coefficients between stress-induced change in JNK activity and pHi.

    Article Snippet: For siRNA-mediated JNK1 and JNK2 knockdown, cells were transfected with 1, 6 or 25 pmol ON-TARGET plus Human MAPK8 SMART pool siRNA (Dharmacon, L-003514-00-0020) and/or ON-TARGET plus Human MAPK9 SMART pool siRNA (Dharmacon, L-003505-00-0020) with 2 µl RNAiMAX (Thermo Fisher Scientific), according to the manufacturer’s protocol.

    Techniques: Control, Activity Assay, Transfection